Endostatin in 3D Fibrin Hydrogel Scaffolds Promotes Chondrogenic Differentiation in Swine Neonatal Meniscal Cells

Autor: Valentina Rafaela Herrera Millar, Barbara Canciani, Laura Mangiavini, Joel Fernando Soares Filipe, Lucia Aidos, Margherita Pallaoro, Giuseppe Maria Peretti, Paola Pocar, Silvia Clotilde Modina, Alessia Di Giancamillo

Publikováno v: Biomedicines, Vol 10, Iss 10, p 2415 (2022)

The success of cell-based approaches for the treatment of cartilage or fibro-cartilaginous tissue defects requires an optimal cell source with chondrogenic differentiation ability that maintains its differentiated properties and stability following i

Externí odkaz: https://doaj.org/article/6b4cbc3ea92a448792faacc83ee23702

High-throughput screening for modulators of ACVR1 transcription: discovery of potential therapeutics for fibrodysplasia ossificans progressiva

Autor: Serena Cappato, Laura Tonachini, Francesca Giacopelli, Mario Tirone, Luis J. V. Galietta, Martina Sormani, Anna Giovenzana, Antonello E. Spinelli, Barbara Canciani, Silvia Brunelli, Roberto Ravazzolo, Renata Bocciardi

Publikováno v: Disease Models & Mechanisms, Vol 9, Iss 6, Pp 685-696 (2016)

The ACVR1 gene encodes a type I receptor of bone morphogenetic proteins (BMPs). Activating mutations in ACVR1 are responsible for fibrodysplasia ossificans progressiva (FOP), a rare disease characterized by congenital toe malformation and progressive

Externí odkaz: https://doaj.org/article/bc8881ef03a44f499df1f39179097a51

High-Resolution X-Ray Tomography: A 3D Exploration Into the Skeletal Architecture in Mouse Models Submitted to Microgravity Constraints

Autor: Alessandra Giuliani, Serena Mazzoni, Alessandra Ruggiu, Barbara Canciani, Ranieri Cancedda, Sara Tavella

Publikováno v: Frontiers in Physiology, Vol 9 (2018)

Bone remodeling process consists in a slow building phase and in faster resorption with the objective to maintain a functional skeleton locomotion to counteract the Earth gravity. Thus, during spaceflights, the skeleton does not act against gravity,

Externí odkaz: https://doaj.org/article/63ed7c70b80f43f1b31ea6cfc7b9e009

Testing Hypoxia in Pig Meniscal Culture: Biological Role of the Vascular-Related Factors in the Differentiation and Viability of Neonatal Meniscus

Autor: Giuseppe M. Peretti, Barbara Canciani, Luigi Anastasia, Federica Cirillo, Margherita Pallaoro, Alessia Di Giancamillo, Silvia Modina, Valentina Rafaela Herrera Millar, Laura Mangiavini, Lucia Aidos

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12465, p 12465 (2021)
Volume 22
Issue 22

Menisci play an essential role in shock absorption, joint stability, load resistance and its transmission thanks to their conformation. Adult menisci can be divided in three zones based on the vascularization: an avascular inner zone with no blood su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b398217c93bd66f023cf7f5d0081d788
https://pubmed.ncbi.nlm.nih.gov/34830345

Hypoxia as a Stimulus for the Maturation of Meniscal Cells: Highway to Novel Tissue Engineering Strategies?

Autor: Federica Cirillo, Silvia Modina, Giuseppe M. Peretti, Luigi Anastasia, Alessia Di Giancamillo, Umberto Polito, Van Thi Nguyen, Laura Mangiavini, Barbara Canciani, Valentina Rafaela Herrera Millar

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 13
International Journal of Molecular Sciences, Vol 22, Iss 6905, p 6905 (2021)

The meniscus possesses low self-healing properties. A perfect regenerative technique for this tissue has not yet been developed. This work aims to evaluate the role of hypoxia in meniscal development in vitro. Menisci from neonatal pigs (day 0) were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7dc521e4e6294f048930e0c7c163bcf