Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Barbara C. Halpern"'
Publikováno v:
Clinica Chimica Acta. 113:231-242
Urinary excretion levels of seven unconjugated pterins in healthy individuals and in cancer patients, most of whom were undergoing chemotherapy, were measured utilizing a newly developed high-pressure liquid chromatographic system. Excretion of pteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732db19b3836a5ba61caec15bc41d8d9
https://doi.org/10.1016/0009-8981(81)90277-1
https://doi.org/10.1016/0009-8981(81)90277-1
Autor:
D. Hardy, Hilary Ashe, Richard M. Halpern, Roberts A. Smith, Barbara C. Halpern, Robert Ezzell, Brian R. Clark
Publikováno v:
In Vitro. 11:14-19
When malignant W-256 rat breast carcinosarcoma cells are mixed with an equal number of normal adult rat liver fibroblasts and allowed to grow in a medium containing sufficientl-methionine and an excess of vitamin B12 and of folic acid, the malignant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837e65004c11e9d0a127b877b666c94e
https://doi.org/10.1007/bf02615317
https://doi.org/10.1007/bf02615317
Quantitative determination of pterins in biological fluids by high-performance liquid chromatography
Publikováno v:
Journal of Chromatography A. 188:363-375
During our continuing study of pteridine metabolism, the need arose for a more rapid and quantitative determination of pterins in biological fluids. By adopting and modifying previously developed techniques, we have obtained a rapid and sensitive met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c51a4d940aaf4f05e23d6bc7770483
https://doi.org/10.1016/s0021-9673(00)81259-5
https://doi.org/10.1016/s0021-9673(00)81259-5
Autor:
David G. Pritchard, Richard M. Halpern, Roberts A. Smith, James A. Halpern, Barbara C. Halpern
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 404:289-299
A new procedure for the fractionation of mucopolysaccharides based upon differences in their partition behavior in aqueous polymer two-phase systems has been devised. Systems containing dextran, poly(ethylene glycol), trimethylamino-poly(ethylene gly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5de1c5120a3d789b0c42ad8b6415d1b8
https://doi.org/10.1016/0304-4165(75)90336-0
https://doi.org/10.1016/0304-4165(75)90336-0
Autor:
D. Hardy, Brian R. Clark, Pamela Y. Jenkinson, Shao-Chia Chou, Hilary L. Ashe, Roberts A. Smith, Barbara C. Halpern, Richard M. Halpern
Publikováno v:
Proceedings of the National Academy of Sciences. 72:4018-4022
The selective toxicity of antifolates for a variety of cancers can be improved, as illustrated by the combined administration of N5-methyltetrahydrofolate and methotrexate in tissue culture. When a variety of neoplastic cell types characterized by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f71da57515c7da4f4b812fadd4762254
https://doi.org/10.1073/pnas.72.10.4018
https://doi.org/10.1073/pnas.72.10.4018
Publikováno v:
Proceedings of the National Academy of Sciences. 71:1133-1136
In tissue cultures of normal adult and malignant mammalian cells, homocystine has been substituted for methionine in a medium rich in folic acid and cyanocobalamin. Normal adult cells thrive. Three highly malignant cell types from three different spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08948c366982206fd7a4480b9405b449
https://doi.org/10.1073/pnas.71.4.1133
https://doi.org/10.1073/pnas.71.4.1133
Publikováno v:
Biochemical and Biophysical Research Communications. 42:602-607
A dialyzable tRNA methylase inhibitor has been isolated from rat liver. By chromatographic and electrophoretic data as well as ultraviolet and mass spectral data, the inhibitor is identified as nicotinamide. Kinetic evidence indicates that nicotinami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d6d3425b4f6704be0e1780aee62b611
https://doi.org/10.1016/0006-291x(71)90530-4
https://doi.org/10.1016/0006-291x(71)90530-4
Publikováno v:
Biochemical and Biophysical Research Communications. 40:1209-1215
With acid precipitation and dialysis, we show the presence of tRNA methylase inhibitors in normal adult rat liver. These inhibitors are virtually absent from the cortex of the highly malignant Walker-256 carcinoma from the rat. The tRNA methylase inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d49d984c0e1c43e9faa2fdf1d990aef
https://doi.org/10.1016/0006-291x(70)90924-1
https://doi.org/10.1016/0006-291x(70)90924-1
Publikováno v:
Proceedings of the National Academy of Sciences. 67:1827-1833
Walker-256 carcinosarcoma cells grown in tissue culture medium containing inhibitory DNA prepared from the tumor are shown to have an unaltered growth in vitro , but a diminished capacity to produce malignant tumors on injection into the rat. Coincid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca461d1460507060dde0d0f6b25cb39
https://doi.org/10.1073/pnas.67.4.1827
https://doi.org/10.1073/pnas.67.4.1827
Autor:
A. Dunlap, J. A. Halpern, Baldassarre Stea, Kenneth A. Conklin, L. Sperling, Hilary L. Ashe, D. Hardy, Roberts A. Smith, Barbara C. Halpern, Brian R. Clark, Richard M. Halpern
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 74(2)
Active folic acid degradation with the formation pterin-6-aldehyde is a previously undescribed characteristic of cancer cells in tissue culture. Neither normal adult epithelial and fibroblastic cells nor human amniotic cells nor mouse embryonic fibro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b200b24832394c2814d1b618bda8e87
https://pubmed.ncbi.nlm.nih.gov/265525
https://pubmed.ncbi.nlm.nih.gov/265525