Zobrazeno 1 - 10
of 241
pro vyhledávání: '"Barbara C. Furie"'
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
What keeps blood from clotting in homeostasis is a puzzle. Here, the authors suggest that lack of the enzyme disulfide isomerase (PDI) in the blood is key, and show that PDI is secreted only after vascular injury to act on substrates that include vit
Externí odkaz:
https://doaj.org/article/46b7214a18e6426fb3abcf41ea49708f
Autor:
Bruce Furie, Barbara C. Furie, Kenneth A. Bauer, Romaric Lacroix, Donna Neuberg, Howard A. Liebman, Jeffrey I. Zwicker
Supplementary Data from Tumor-Derived Tissue FactorBearing Microparticles Are Associated With Venous Thromboembolic Events in Malignancy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aad7e6012ac0ad4c3e2cd36979c9984
https://doi.org/10.1158/1078-0432.22440705
https://doi.org/10.1158/1078-0432.22440705
Autor:
Bruce Furie, Barbara C. Furie, Kenneth A. Bauer, Romaric Lacroix, Donna Neuberg, Howard A. Liebman, Jeffrey I. Zwicker
Purpose: Despite the strong association between malignant disease and thromboembolic disorders, the molecular and cellular basis of this relationship remains uncertain. We evaluated the hypothesis that tumor-derived tissue factorbearing microparticle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c634474010be5e2c11d7ef2fe4af70
https://doi.org/10.1158/1078-0432.c.6518001
https://doi.org/10.1158/1078-0432.c.6518001
Autor:
Cai Yuan, Valérie Proulle, Guangpu Xue, Peter A. Andreasen, Chao Fang, Mingdong Huang, Zhonghui Lin, Min Liu, Robert Flaumenhaft, Zebin Hong, Lin Lin, Bruce Furie, Lihu Gong, Barbara C. Furie
Publikováno v:
Journal of Cellular and Molecular Medicine
Gong, L, Proulle, V, Fang, C, Hong, Z, Lin, Z, Liu, M, Xue, G, Yuan, C, Lin, L, Furie, B, Flaumenhaft, R, Andreasen, P, Furie, B & Huang, M 2016, ' A specific plasminogen activator inhibitor-1 antagonist derived from inactivated urokinase ', Journal of Cellular and Molecular Medicine (Online), vol. 20, no. 10, pp. 1851-1860 . https://doi.org/10.1111/jcmm.12875
Gong, L, Proulle, V, Fang, C, Hong, Z, Lin, Z, Liu, M, Xue, G, Yuan, C, Lin, L, Furie, B, Flaumenhaft, R, Andreasen, P, Furie, B & Huang, M 2016, ' A specific plasminogen activator inhibitor-1 antagonist derived from inactivated urokinase ', Journal of Cellular and Molecular Medicine (Online), vol. 20, no. 10, pp. 1851-1860 . https://doi.org/10.1111/jcmm.12875
Fibrinolysis is a process responsible for the dissolution of formed thrombi to re‐establish blood flow after thrombus formation. Plasminogen activator inhibitor‐1 (PAI‐1) inhibits urokinase‐type and tissue‐type plasminogen activator (uPA an
Autor:
Vivien M. Chen, Reema Jasuja, Robert Flaumenhaft, Lola Bellido-Martin, Pavan K. Bendapudi, Bruce Furie, Barbara C. Furie, Sol Schulman, Anish V. Sharda
Publikováno v:
Antioxidants & Redox Signaling. 24:1-15
Significance: The mammalian endoplasmic reticulum (ER) houses a large family of twenty thioredoxin-like proteins of which protein disulfide isomerase (PDI) is the archetypal member. Although the PDI family is best known for its role in oxidative prot
Autor:
Freda Passam, Bruce Furie, Srila Gopal, Lola Bellido-Martin, Lin Lin, Barbara C. Furie, Mingdong Huang, Jack D. Stopa
Publikováno v:
Blood. 125:2276-2285
Protein disulfide isomerase (PDI) and endoplasmic reticulum protein 57 (ERp57) are emerging as important regulators of thrombus formation. Another thiol isomerase, endoplasmic reticulum protein 5 (ERp5), is involved in platelet activation. We show he
Autor:
Srila Gopal, Reema Jasuja, Robert Flaumenhaft, Bruce Furie, Sarah H. Kim, Barbara C. Furie, Anish V. Sharda
Publikováno v:
Blood. 125:1633-1642
Protein disulfide isomerase (PDI), secreted from platelets and endothelial cells after injury, is required for thrombus formation. The effect of platelet and endothelial cell granule contents on PDI-mediated thrombus formation was studied by intravit
Autor:
Dana Boyd, Holly K. Arnold, Ludmila Bronstain, Brian M. Meehan, Shoko Minami, Cristina Landeta, Eric J. Rubin, Na Ke, Alissa Myrick, Feras Hatahet, Rachel J. Dutton, Jessica L. Blazyk, Bruce Furie, Barbara C. Furie, Jon Beckwith, Markus Eser
Publikováno v:
Nature chemical biology
In bacteria, disulfide bonds confer stability on many proteins exported to the cell envelope or beyond. These proteins include numerous bacterial virulence factors, and thus bacterial enzymes that promote disulfide bond formation represent targets fo
Publikováno v:
Blood. 124:611-622
Antiphospholipid syndrome (APS) is defined by thrombosis, fetal loss, and the presence of antiphospholipid antibodies, including anti–β2-glycoprotein-1 autoantibodies (anti-β2GP1) that have a direct role in the pathogenesis of thrombosis in vivo.
Autor:
Jaehyung Cho, Lin Lin, Mingdong Huang, Barbara C. Furie, Daniel R. Kennedy, Glenn Merrill-Skoloff, Bruce Furie
Publikováno v:
Blood. 120:647-655
Extracellular protein disulfide isomerase (PDI) is required for platelet thrombus formation and fibrin generation after arteriolar wall injury in live mice. PDI is secreted from platelets and endothelial cells on cellular activation, but the mechanis