Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Barbara C. Fam"'
Autor:
Yann W. Yap, Patricia M. Rusu, Andrea Y. Chan, Barbara C. Fam, Andreas Jungmann, Samantha M. Solon-Biet, Christopher K. Barlow, Darren J. Creek, Cheng Huang, Ralf B. Schittenhelm, Bruce Morgan, Dieter Schmoll, Bente Kiens, Matthew D. W. Piper, Mathias Heikenwälder, Stephen J. Simpson, Stefan Bröer, Sofianos Andrikopoulos, Oliver J. Müller, Adam J. Rose
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Dietary protein dilution, where protein is reduced and replaced by other nutrient sources without caloric restriction, promotes metabolic health via the hepatokine Fgf21. Here, the authors show that essential amino acids threonine and tryptophan are
Externí odkaz:
https://doaj.org/article/36856bb21e41464a998b62244a235694
Autor:
Stefan Bröer, Christopher K. Barlow, Cheng Huang, Stephen J. Simpson, Darren J. Creek, Dieter Schmoll, Matthew D.W. Piper, Andrea Y. Chan, Samantha M. Solon-Biet, Bente Kiens, Oliver J. Müller, Yann W. Yap, Adam J. Rose, Barbara C Fam, Bruce A. Morgan, Mathias Heikenwalder, Andreas Jungmann, Patricia M. Rusu, Ralf B. Schittenhelm, Sofianos Andrikopoulos
Publikováno v:
Yap, Y W, Rusu, P M, Chan, A Y, Fam, B C, Jungmann, A, Solon-Biet, S M, Barlow, C K, Creek, D J, Huang, C, Schittenhelm, R B, Morgan, B, Schmoll, D, Kiens, B, Piper, M D W, Heikenwälder, M, Simpson, S J, Bröer, S, Andrikopoulos, S, Müller, O J & Rose, A J 2020, ' Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution ', Nature Communications, vol. 11, no. 1, 2894 . https://doi.org/10.1038/s41467-020-16568-z
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Dietary protein dilution (DPD) promotes metabolic-remodelling and -health but the precise nutritional components driving this response remain elusive. Here, by mimicking amino acid (AA) supply from a casein-based diet, we demonstrate that restriction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294484612c08d31e43d4f4a8d0080aa1
https://curis.ku.dk/portal/da/publications/restriction-of-essential-amino-acids-dictates-the-systemic-metabolic-response-to-dietary-protein-dilution(e8d27972-1dda-47ed-b3fe-10a2460ee39b).html
https://curis.ku.dk/portal/da/publications/restriction-of-essential-amino-acids-dictates-the-systemic-metabolic-response-to-dietary-protein-dilution(e8d27972-1dda-47ed-b3fe-10a2460ee39b).html
Autor:
Barbara C. Fam, Christopher K. Barlow, Patricia M. Rusu, Samantha M. Solon-Biet, Cheng Huang, Dieter Schmoll, Stefan Bröer, Bruce A. Morgan, Matthew D.W. Piper, Andreas Jungmann, Ralf B. Schittenhelm, Mathias Heikenwalder, Darren J. Creek, Adam J. Rose, Stephen J. Simpson, Andrea Y. Chan, Oliver J. Müller, Bente Kiens, Yann W. Yap, Sofianos Andrikopoulos
Dietary protein dilution (DPD) promotes metabolic remodelling and health but the precise nutritional components driving this response remain elusive. Here we demonstrate that dietary amino acids (AA) are sufficient and necessary to drive the response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7b6bcb9e61e03d8c3db9b39d411858
Autor:
Jarrod P Skinner, Maria Ws Chiu, Barbara C Fam, Nicole K. L. Lee, Kesha Rana, Patricia K Russell, Jeffrey D Zajac, Helen E. MacLean
Publikováno v:
Journal of Molecular Endocrinology. 57:125-138
The aim of this study was to investigate the direct muscle cell-mediated actions of androgens by comparing two different mouse lines. The cre-loxP system was used to delete the DNA-binding activity of the androgen receptor (AR) in mature myofibers (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2c171cd5c24b3d6362dda2739e8dff
https://doi.org/10.1530/jme-15-0320
https://doi.org/10.1530/jme-15-0320
Autor:
Jeffrey D Zajac, Rachel A Davey, Evelyn S Marin, Michele V Clarke, Salvatore P. Mangiafico, Barbara C Fam, Sofianos Andrikopoulos, Kristine M. Wiren, Patricia K Russell
Publikováno v:
The Journal of endocrinology. 237(1)
It is well established that testosterone negatively regulates fat mass in humans and mice; however, the mechanism by which testosterone exerts these effects is poorly understood. We and others have shown that deletion of the androgen receptor (AR) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950193090a4453ff006b96fbbd88de09
https://pubmed.ncbi.nlm.nih.gov/29386237
https://pubmed.ncbi.nlm.nih.gov/29386237
Autor:
Garron T. Dodd, Melanie Tran, Florian Wiede, Tony Tiganis, Matthew J. Watt, Maria Stathopoulos, Iain J. Clarke, Troy L. Merry, Barbara C Fam, Sofianos Andrikopoulos
Publikováno v:
Antioxidants & Redox Signaling. 20:2114-2129
Reactive oxygen species (ROS) such as H2O2 can promote signaling through the inactivation of protein tyrosine phosphatases (PTPs). However, in obesity, the generation of ROS exceeds the antioxidant reserve and can contribute to the promotion of insul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6fc9f022f0f13f8f48e9fb83868a65d
https://doi.org/10.1089/ars.2013.5428
https://doi.org/10.1089/ars.2013.5428
Autor:
Henrik Ortsäter, Li Lu, Sofianos Andrikopoulos, Sharon Stone-Elander, Annelie Falkevall, Daniel Nyqvist, Andrew D. Nash, Annika Mehlem, Barbara C Fam, Lars Muhl, Åke Sjöholm, Ulf Eriksson, Carolina E. Hagberg, Joseph Proietto, Erik Samén, Pierre Scotney
Publikováno v:
Nature. 490:426-430
The prevalence of type 2 diabetes is rapidly increasing, with severe socioeconomic impacts. Excess lipid deposition in peripheral tissues impairs insulin sensitivity and glucose uptake, and has been proposed to contribute to the pathology of type 2 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d148e973e9a053b3fe191254705289dc
https://doi.org/10.1038/nature11464
https://doi.org/10.1038/nature11464
Autor:
Zheng Ruan, Barbara C Fam, Rebecca Sgambellone, Sofianos Andrikopoulos, Laura J Rose, Joseph Proietto
Publikováno v:
Journal of Endocrinology. 214:313-327
Skeletal muscle insulin resistance is a major characteristic underpinning type 2 diabetes. Impairments in the insulin responsiveness of the glucose transporter,Glut4 (Slc2a4), have been suggested to be a contributing factor to this disturbance. We ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1edf9a5a736f92618523b08d600356e1
https://doi.org/10.1530/joe-12-0032
https://doi.org/10.1530/joe-12-0032
Autor:
Helen E. MacLean, Barbara C Fam, Tammy P S Pang, Jeffrey D Zajac, Kesha Rana, Michele V Clarke
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 301:E767-E778
In men, as testosterone levels decrease, fat mass increases and muscle mass decreases. Increased fat mass in men, in particular central obesity, is a major risk factor for type 2 diabetes, cardiovascular disease, and all-cause mortality. Testosterone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113a6121db80894378fad625ef52804c
https://doi.org/10.1152/ajpendo.00584.2010
https://doi.org/10.1152/ajpendo.00584.2010
Autor:
Ken Walder, Barbara C Fam, Gitta R. Cempako, Gregory R. Steinberg, Sofianos Andrikopoulos, Joseph Proietto, Nicole Wong, Thomas W.H. Kay
Publikováno v:
Endocrinology. 152:3690-3699
Obesity is a chronic low-grade inflammatory disease caused by increased energy intake and reduced energy expenditure. Studies using animal models with deletion of inflammatory cytokines have produced conflicting results with some showing increased we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890c7e0b34cda29b39adde3610b530b6
https://doi.org/10.1210/en.2011-0288
https://doi.org/10.1210/en.2011-0288