Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Barbara Brooks-Worrell"'
Autor:
GRADE Research Group, Ashok Balasubramanyam, Jerry P. Palmer, Ali Shojaie, GRADE Beta-cell Ancillary Study Network, Willy Marcos Valencia, Hermes J. Florez, Jean Y. Park, Robert M. Cohen, Cyrus Desouza, Neda Rasouli, Naji Younes, Kieren J. Mather, Mary L. Johnson, Mary E. Larkin, Steven E. Kahn, Kristina Utzschneider, Sahar Z. Zangeneh, Brenda Palomino, Erica G. Hattery, Christiane S. Hampe, Barbara Brooks-Worrell
Islet autoimmunity may contribute to β-cell dysfunction in type 2 diabetes (T2D). Its prevalence and clinical significance have not been rigorously determined. In this ancillary study to the Glycemia Reduction Approaches in Diabetes-A Comparative Ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a07137ab1c34b08b6cce341320f41b
https://doi.org/10.2337/figshare.18621602.v1
https://doi.org/10.2337/figshare.18621602.v1
Publikováno v:
Diabetes Care
Islet autoimmunity has been identified as a component of both type 1 (T1D) and type 2 (T2D) diabetes, but the pathway through which islet autoimmunity develops in T1D and T2D may be different. Acknowledging the presence of islet autoimmunity in the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0efeef682f49b67c69bce2f6e38a1baf
https://doi.org/10.2337/dc19-0475
https://doi.org/10.2337/dc19-0475
Autor:
Barbara Brooks-Worrell, Christiane S. Hampe, Erica G. Hattery, Brenda Palomino, Sahar Z. Zangeneh, Kristina Utzschneider, Steven E. Kahn, Mary E. Larkin, Mary L. Johnson, Kieren J. Mather, Naji Younes, Neda Rasouli, Cyrus Desouza, Robert M. Cohen, Jean Y. Park, Hermes J. Florez, Willy Marcos Valencia, GRADE Beta-cell Ancillary Study Network, Ali Shojaie, Jerry P. Palmer, Ashok Balasubramanyam, GRADE Research Group
Publikováno v:
SSRN Electronic Journal.
Background: Islet autoimmunity may contribute to beta-cell dysfunction in type 2 diabetes (T2D). Its prevalence and clinical significance have not been rigorously determined. We investigated the prevalence of cellular and humoral islet autoimmunity i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43438ac22b86474f031b36a5b02e5e2e
https://doi.org/10.2139/ssrn.3810751
https://doi.org/10.2139/ssrn.3810751
Autor:
Thomas A. Buchanan, Elena Barengolts, Kieren J. Mather, Karen M. Atkinson, Barbara Brooks-Worrell, Kristen J. Nadeau, Kristina M. Utzschneider, Brenda M. Palomino, Sharon L. Edelstein, Steven E. Kahn, Jerry P. Palmer, Silva A. Arslanian, Ashley H. Tjaden
Publikováno v:
Diabetes. 69
In obesity, immune cells establish a systemic inflammatory state associated with development of insulin resistance and T2D. Previous studies have shown that peripheral blood mononuclear cell (PBMC) responses to islet proteins (IPs) in adults with est
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78b3fa3a57db2dbfaa2e608e63a42b90
https://doi.org/10.2337/db20-1679-p
https://doi.org/10.2337/db20-1679-p
Autor:
Kristina M. Utzschneider, Naji Younes, Sahar Z Zangeneh, Mary L. Johnson, Erica V. Gonzalez, Ashok Balasubramanyam, Robert M. Cohen, Ali Shojaie, Christiane S. Hampe, Mary E. Larkin, Neda Rasouli, Steven E. Kahn, Kieren J. Mather, Barbara Brooks-Worrell, Jean Y. Park, Hermes Florez, Brenda M. Palomino, Cyrus Desouza, Jerry P. Palmer, Willy Marcos Valencia
Publikováno v:
Diabetes. 69
We hypothesized that islet autoimmunity, hitherto considered the pathophysiologic basis of type 1 diabetes (T1D) and latent autoimmune diabetes of adults (LADA), could contribute to ß cell dysfunction in patients with type 2 diabetes (T2D). To evalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2970e1217a4a4d75b91dc9ec4a287c7e
https://doi.org/10.2337/db20-254-or
https://doi.org/10.2337/db20-254-or
Publikováno v:
Diabetes Care
OBJECTIVE Cross-sectional studies have suggested that islet autoimmunity may be more prevalent in type 2 diabetes (T2D) than previously appreciated and may contribute to the progressive decline in β-cell function. In this study, we longitudinally ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeb6b53b61bdcb277f2701d15fb0ee5b
https://doi.org/10.2337/dc14-0961
https://doi.org/10.2337/dc14-0961
Autor:
Jerry P. Palmer, Ashok Balasubramanyam, Radhika R. Narla, Christiane S. Hampe, Kerem Ozer, Ramaswami Nalini, Dinakar Iyer, Barbara Brooks-Worrell, Ivonne Coraza
Publikováno v:
Diabetes Care
OBJECTIVE Ketosis-prone diabetes (KPD) is characterized by diabetic ketoacidosis (DKA) in patients lacking typical features of type 1 diabetes. A validated classification scheme for KPD includes two autoantibody-negative (“A−”) phenotypic forms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4209b7b01fa84c10dc2d02967568470
http://europepmc.org/articles/PMC3836121
http://europepmc.org/articles/PMC3836121
Publikováno v:
Clinical and Experimental Immunology. 171:164-170
Summary The clinical efficacy of peroxisome proliferator-activated receptor gamma (PPAR-γ) agonists in cell-mediated autoimmune diseases results from down-regulation of inflammatory cytokines and autoimmune effector cells. T cell islet autoimmunity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0df97922c9925b7992bb91681031f3
https://doi.org/10.1111/cei.12012
https://doi.org/10.1111/cei.12012
Autor:
Barbara Brooks-Worrell, Marli McCulloch-Olson, Jerry P. Palmer, Carla J. Greenbaum, Harvey K Chiu
Publikováno v:
Pediatric Diabetes. 12:150-155
Greenbaum CJ, McCulloch-Olson M, Chiu HK, Palmer JP, Brooks-Worrell B. Parenteral insulin suppresses T cell proliferation to islet antigens. The diabetes prevention trial-type 1 (DPT-1) tested whether a combination of SQ and IV insulin therapy would
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad026017e2bca952481dbfc80c207c34
https://doi.org/10.1111/j.1399-5448.2010.00674.x
https://doi.org/10.1111/j.1399-5448.2010.00674.x
Publikováno v:
Diabetes Care
OBJECTIVE Islet autoimmunity has long been recognized in the pathogenesis of type 1 diabetes and is becoming increasingly acknowledged as a component in the pathogenesis of type 2 diabetes. Islet reactive T cells and autoantibodies have been demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f85ca7f7ad2c424e8d05c8b9d46f3ec
http://europepmc.org/articles/PMC3004952
http://europepmc.org/articles/PMC3004952