Výsledky vyhledávání - "Barbara Blouw"

Akademický článek

The HER2 flip-HER2 amplification of tumor cells in the cerebrospinal fluid of breast cancer patients with leptomeningeal disease: implications for treating the LM tumor with anti-HER2 therapy

Autor: Priya U. Kumthekar, Barbara Blouw, Perry Corkos, Seema Nagpal, Arushi Tripathy, David Piccioni, Michael Youssef

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

IntroductionCNSide is a platform that detects and characterizes tumor cells in the cerebrospinal fluid (CSF) of patients with leptomeningeal disease (LMD). The platform was validated per College of American Pathologists (CAP) and Clinical Laboratorie

Externí odkaz: https://doaj.org/article/a4602abf11c5492b932f0f10399332db

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Akademický článek

Investigating the contribution of hyaluronan to the breast tumour microenvironment using multiparametric MRI and MR elastography

Autor: Emma L. Reeves, Jin Li, Konstantinos Zormpas‐Petridis, Jessica K. R. Boult, James Sullivan, Craig Cummings, Barbara Blouw, David Kang, Ralph Sinkus, Jeffrey C. Bamber, Yann Jamin, Simon P. Robinson

Publikováno v: Molecular Oncology, Vol 17, Iss 6, Pp 1076-1092 (2023)

Hyaluronan (HA) is a key component of the dense extracellular matrix in breast cancer, and its accumulation is associated with poor prognosis and metastasis. Pegvorhyaluronidase alfa (PEGPH20) enzymatically degrades HA and can enhance drug delivery a

Externí odkaz: https://doaj.org/article/d856a9c4b07f46b8bc43ce545a5752bf

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Akademický článek

PEGylated recombinant human hyaluronidase (PEGPH20) pre-treatment improves intra-tumour distribution and efficacy of paclitaxel in preclinical models

Autor: Lavinia Morosi, Marina Meroni, Paolo Ubezio, Ilaria Fuso Nerini, Lucia Minoli, Luca Porcu, Nicolò Panini, Marika Colombo, Barbara Blouw, David W. Kang, Enrico Davoli, Massimo Zucchetti, Maurizio D’Incalci, Roberta Frapolli

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-13 (2021)

Abstract Background Scarce drug penetration in solid tumours is one of the possible causes of the limited efficacy of chemotherapy and is related to the altered tumour microenvironment. The abnormal tumour extracellular matrix (ECM) together with abn

Externí odkaz: https://doaj.org/article/4214b5ab153e4739bc53c7865dca3750

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Akademický článek

A Preclinical Investigation into the Effects of Aging on Dermal Hyaluronan Properties and Reconstitution Following Recombinant Human Hyaluronidase PH20 Administration

Autor: Robert J. Connor, Barbara Blouw, Jessica Cowell, Kelly Chen, Chunmei Zhao, David W. Kang

Publikováno v: Dermatology and Therapy, Vol 10, Iss 3, Pp 503-513 (2020)

Abstract Introduction There is currently no consensus in the literature concerning the impact of aging on the properties of hyaluronan (HA) in the subcutaneous (SC) space. Recombinant human hyaluronidase PH20 (rHuPH20) facilitates SC administration o

Externí odkaz: https://doaj.org/article/c223b4dc9f09491eb56f35542dcfc11e

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Akademický článek

The invadopodia scaffold protein Tks5 is required for the growth of human breast cancer cells in vitro and in vivo.

Autor: Barbara Blouw, Manishha Patel, Shinji Iizuka, Christopher Abdullah, Weon Kyoo You, Xiayu Huang, Jian-Liang Li, Begoña Diaz, William B Stallcup, Sara A Courtneidge

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0121003 (2015)

The ability of cancer cells to invade underlies metastatic progression. One mechanism by which cancer cells can become invasive is through the formation of structures called invadopodia, which are dynamic, actin-rich membrane protrusions that are sit

Externí odkaz: https://doaj.org/article/e63e1d07d2c44817bf867016c449cb17

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