Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Barbara Bertocci"'
Autor:
Shuaishuai Zhu, Emmanuelle Waeckel-Énée, Masaya Oshima, Anna Moser, Marie-Andrée Bessard, Abdelaziz Gdoura, Kevin Roger, Nina Mode, Joanna Lipecka, Ayse Yilmaz, Barbara Bertocci, Julien Diana, Benjamin Saintpierre, Ida Chiara Guerrera, Raphael Scharfmann, Stefania Francesconi, François-Xavier Mauvais, Peter van Endert
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109929- (2024)
Summary: Tuning of protein homeostasis through mobilization of the unfolded protein response (UPR) is key to the capacity of pancreatic beta cells to cope with variable demand for insulin. Here, we asked how insulin-degrading enzyme (IDE) affects bet
Externí odkaz:
https://doaj.org/article/ef74b2002b644e86886ed16b4a9bb5e4
Autor:
Ayse Yilmaz, Chiara Guerrera, Emmanuelle Waeckel-Énée, Joanna Lipecka, Barbara Bertocci, Peter van Endert
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 890 (2023)
Insulin-degrading enzyme (IDE) is a highly conserved metalloprotease that is mainly localized in the cytosol. Although IDE can degrade insulin and some other low molecular weight substrates efficiently, its ubiquitous expression suggests additional f
Externí odkaz:
https://doaj.org/article/efcd5ab347e24b2098cf151936445e13
Autor:
Elena K Braithwaite, Padmini S Kedar, Deborah J Stumpo, Barbara Bertocci, Jonathan H Freedman, Leona D Samson, Samuel H Wilson
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12229 (2010)
Base excision repair (BER) is a DNA repair pathway designed to correct small base lesions in genomic DNA. While DNA polymerase beta (pol beta) is known to be the main polymerase in the BER pathway, various studies have implicated other DNA polymerase
Externí odkaz:
https://doaj.org/article/39f1c48a89724a2ba4c79f86b70e38f8
Autor:
Lars Nitschke, Lena Reimann, Alexander Böser, Sarah J Meyer, Barbara Bertocci, Bettina Warscheid, Claudia Koller, Marina A Korn
Publikováno v:
The Journal of Immunology. 204:3360-3374
B lymphocytes are important players of the adaptive immune system. However, not just activation of B cells but also regulation of B cell signaling is important to prevent hyperactivity and dysregulation of the immune response. Different mechanisms an
Autor:
Barbara Bertocci, Paola Cavallero
Publikováno v:
RICERCHE DI PSICOLOGIA. :743-768
Autor:
Auriel Dahan, Frédérique Lembo, Annie De Smet, Christine Bole-Feysot, Jean-Claude Weill, Damiana Lecoeuche, Nicolas Cagnard, Delphine Sterlin, Barbara Bertocci, Tatiana Fadeev, Baptiste Gaillard, Claude-Agnès Reynaud, Julius Kühn
Publikováno v:
The Journal of Immunology. 199:2408-2420
Klhl6 belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. Several of these proteins function as adaptors of the Cullin3 E3 ubiquitin ligase complex. In this article, we report tha
Publikováno v:
DNA Repair. 12:1087-1093
During somatic hypermutation (SHM) of antibody variable (V) region genes, activation-induced cytidine deaminase (AID) converts dC to dU, and dUs can either be excised by uracil DNA glycosylase (UNG), by mismatch repair, or replicated over. If UNG exc
Autor:
Jérôme Mégret, Barbara Bertocci, Frédéric Delbos, Jean-Claude Weill, Ismail Dogan, Valérie Vilmont, Sébastien Storck, Claude-Agnès Reynaud
Publikováno v:
Nature Immunology. 10:1292-1299
Memory B cells are at the center of longstanding controversies regarding the presence of antigen for their survival and their re-engagement in germinal centers after secondary challenge. Using a new mouse model of memory B cell labeling dependent on
Autor:
Anne Léon, Quentin Gueranger, Ahmad Faili, Said Aoufouchi, Barbara Bertocci, Carole Zober, Claude-Agnès Reynaud, Jean-Claude Weill
Publikováno v:
Nature Immunology. 3:815-821
Immunoglobulin (Ig) gene hypermutation can be induced in the BL2 Burkitt's lymphoma cell line by IgM cross-linking and coculture with normal or transformed T helper clones. We describe here a T cell#150;independent in vitro induction assay, by which
Autor:
Neetu Gupta, Jean-Claude Weill, Said Aoufouchi, Sébastien Storck, Claude-Agnès Reynaud, Barbara Bertocci, Ahmad Faili, Eric Flatter, Auriel Dahan, Laurentiu Cocea, Frédéric Delbos
Publikováno v:
Nucleic Acids Research. 28:3684-3693
We describe here two novel mouse and human DNA polymerases: one (pol lambda) has homology with DNA polymerase beta while the other one (pol mu) is closer to terminal deoxynucleotidyltransferase. However both have DNA polymerase activity in vitro and