Výsledky vyhledávání - "Barbara Belisle"

Chemical Characterization and Biological Properties of NVC-422, a Novel, Stable N -Chlorotaurine Analog

Autor: Wyatt G. Payne, Chris Celeri, Behzad Khosrovi, Lu Wang, Mansour Bassiri, Dmitri Debabov, Barbara Belisle, Martin C. Robson, Nichole J Alvarez, Ping Xu, Ramin Najafi

Publikováno v: Antimicrobial Agents and Chemotherapy. 55:2688-2692

During oxidative burst, neutrophils selectively generate HOCl to destroy invading microbial pathogens. Excess HOCl reacts with taurine, a semi-essential amino acid, resulting in the formation of the longer-lived biogenerated broad-spectrum antimicrob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d46f4ad681d5fdbd0ff7159ae38321
https://doi.org/10.1128/aac.00158-11

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N-Formyl Peptide Receptor Ligation Induces Rac-dependent Actin Reorganization through Gβγ Subunits and Class Ia Phosphoinositide 3-Kinases

Autor: Barbara Belisle, Arie Abo

Publikováno v: Journal of Biological Chemistry. 275:26225-26232

The N-formyl peptide receptor is a G protein-coupled transmembrane receptor involved in stimulating a variety of differential responses in neutrophils including chemotaxis, degranulation, superoxide production, transcriptional activation, and actin r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d474fc9c36cc263e39b17b6517dd084d
https://doi.org/10.1074/jbc.m002743200

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PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

Autor: Véronique Baud, Audrey Minden, Alexandra Fritsch, Barbara Belisle, Arie Abo, Marta S. Cammarano, Chuntao Dan, Jian Qu

Publikováno v: The EMBO Journal. 17:6527-6540

The GTPases Rac and Cdc42Hs control diverse cellular functions. In addition to being mediators of intracellular signaling cascades, they have important roles in cell morphogenesis and mitogenesis. We have identified a novel PAK-related kinase, PAK4,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1416b1c2a914a0c65e21973a12d63ae
https://doi.org/10.1093/emboj/17.22.6527

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N,N-Dichloroaminosulfonic acids as novel topical antimicrobial agents

Autor: Chris Celeri, Rakesh K. Jain, Eddy Low, Timothy P. Shiau, Ron Najafi, Dmitri Debabov, Meghan Zuck, Barbara Belisle, N H Georgopapadakou, Satheesh K. Nair

Publikováno v: Bioorganicmedicinal chemistry letters. 19(1)

2-Dichloroamino-2-methyl-propane-1-sulfonic acid sodium salt (2a), a stable derivative of endogenous N,N-dichlorotaurine (1), has been identified and is under development as a topical antimicrobial agent. Structure-activity relationships of analogs w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e2d6e8ecd8452e5a36da0374d98f5c
https://pubmed.ncbi.nlm.nih.gov/19010674

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A role for Wiskott-Aldrich syndrome protein in T-cell receptor-mediated transcriptional activation independent of actin polymerization

Autor: Arie Abo, Christopher Silvin, Barbara Belisle

Publikováno v: The Journal of biological chemistry. 276(24)

Wiskott-Aldrich syndrome protein (WASP) plays a key role in cytoskeletal rearrangement and transcriptional activation in T-cells. Recent evidence links WASP and related proteins to actin polymerization by the Arp2/3 complex. To study whether the role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a934bb8118a376d2bfe7c66ff0aba81
https://pubmed.ncbi.nlm.nih.gov/11283014

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