Mixed mucosal-parenteral immunizations with the broadly conserved pathogenic Escherichia coli antigen SslE induce a robust mucosal and systemic immunity without affecting the murine intestinal microbiota

Autor: Mariagrazia Pizza, Mickaël Desvaux, Grégory Jubelin, Juliette Vinot, Barbara Baudner, Ugo D'Oro, Annick Bernalier-Donadille, Cecilia Buonsanti, Ilham Naili

Publikováno v: Vaccine
Vaccine, 2019, 37 (2), pp.314-324. ⟨10.1016/j.vaccine.2018.10.008⟩
Vaccine, Elsevier, 2019, 37 (2), pp.314-324. ⟨10.1016/j.vaccine.2018.10.008⟩

International audience; Emergence and dissemination of multidrug resistance among pathogenic Escherichia coli have posed a serious threat to public health across developing and developed countries. In combination with a flexible repertoire of virulen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491dec8874f57a985f7d1b36347f7a45
https://doi.org/10.1016/j.vaccine.2018.10.008

Investigating the Impact of Delivery System Design on the Efficacy of Self-Amplifying RNA Vaccines

Autor: Gustavo Lou, Michela Brazzoli, Russell Johnson, Barbara Baudner, Yvonne Perrie, Derek T. O'Hagan, Giulia Anderluzzi, Simona Gallorini

Publikováno v: Vaccines
Volume 8
Issue 2
Vaccines, Vol 8, Iss 212, p 212 (2020)

messenger RNA (mRNA)-based vaccines combine the positive attributes of both live-attenuated and subunit vaccines. In order for these to be applied for clinical use, they require to be formulated with delivery systems. However, there are limited in vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b606045310c59eb9cb2f21b1c592e9f7

Addition of a TLR7 agonist to an acellular pertussis vaccine enhances Th1 and Th17 responses and protective immunity in a mouse model

Autor: Anja Seubert, Derek T. O'Hagan, Bruno Galletti, Alicja Misiak, Kingston H. G. Mills, Mariagrazia Pizza, Aideen C. Allen, Rosanna Leuzzi, Barbara Baudner, Ugo D'Oro

Publikováno v: Vaccine. 35:5256-5263

A resurgence of whooping cough (pertussis) has been observed in recent years in a number of developed countries, despite widespread vaccine coverage. Although the exact reasons of the recurrence of pertussis are not clear, there are a number of poten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175f5499cfca5a3d67c573a02c628e98
https://doi.org/10.1016/j.vaccine.2017.08.009

Mannosylation of LNP Results in Improved Potency for Self-Amplifying RNA (SAM) Vaccines

Autor: Roshan Goswami, Barbara Baudner, Derek T. O'Hagan, Roberto Adamo, Ilaria Ferlenghi, Francesco Berti, Simona Gallorini, Alessandra Bonci, Marianna Taccone, Despo Chatzikleanthous, Gustavo Lou, Michela Brazzoli, Fabiola Giusti, Carlo Pergola

Publikováno v: ACS Infectious Diseases

Mannosylation of Lipid Nanoparticles (LNP) can potentially enhance uptake by Antigen Presenting Cells, which are highly abundant in dermal tissues, to improve the potency of Self Amplifying mRNA (SAM) vaccines in comparison to the established unmodif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b66e0acb38cb0d3086a8ad5a9ac5e7
https://pubmed.ncbi.nlm.nih.gov/31290323

The adjuvant effect of TLR7 agonist conjugated to a meningococcal serogroup C glycoconjugate vaccine

Autor: Agnese Donadei, Roberto Adamo, Daniela Proietti, Simona Gallorini, Francesca Mancini, Ugo D'Oro, Francesco Berti, Barbara Baudner, Derek T. O'Hagan, Cristiana Balocchi

Publikováno v: European Journal of Pharmaceutics and Biopharmaceutics. 107:110-119

Conjugation of a small molecule immunopotentiator to antigens has been proposed to deliver the ligand to the receptor, localize its action and minimize systemic inflammation. However, the effect of conjugation of Toll like receptor 7 agonists (TLR7a)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515313c0d5d0eb4b33ba3c204d397038
https://doi.org/10.1016/j.ejpb.2016.07.004