Zobrazeno 1 - 10
of 290
pro vyhledávání: '"Barbara B. Kahn"'
Autor:
Shuai Yan, Anna Santoro, Micah J. Niphakis, Antonio M. Pinto, Christopher L. Jacobs, Rasheed Ahmad, Radu M. Suciu, Bryan R. Fonslow, Rachel A. Herbst-Graham, Nhi Ngo, Cassandra L. Henry, Dylan M. Herbst, Alan Saghatelian, Barbara B. Kahn, Evan D. Rosen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Obesity-induced inflammation causes metabolic dysfunction, but the mechanisms remain elusive. Here we show that the innate immune transcription factor interferon regulatory factor (IRF3) adversely affects glucose homeostasis through inductio
Externí odkaz:
https://doaj.org/article/85b643d7bcf449cfb95b22f8c588eacb
Autor:
Jonathan M. Dreyfuss, Yixing Yuchi, Xuehong Dong, Vissarion Efthymiou, Hui Pan, Donald C. Simonson, Ashley Vernon, Florencia Halperin, Pratik Aryal, Anish Konkar, Yinong Sebastian, Brandon W. Higgs, Joseph Grimsby, Cristina M. Rondinone, Simon Kasif, Barbara B. Kahn, Kathleen Foster, Randy Seeley, Allison Goldfine, Vera Djordjilović, Mary Elizabeth Patti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Factors underlying the effects of gastric bypass surgery on glucose homeostasis are incompletely understood. Here the authors developed and applied high-throughput mediation analysis to identify proteome/metabolome mediators of improved glucose homeo
Externí odkaz:
https://doaj.org/article/77b147ec15344c3cb4b79626a96517bd
Autor:
Pratik Aryal, Ismail Syed, Jennifer Lee, Rucha Patel, Andrew T. Nelson, Dionicio Siegel, Alan Saghatelian, Barbara B. Kahn
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100108- (2021)
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are endogenous lipids with antidiabetic and anti-inflammatory effects. Each FAHFA family consists of esters with different acyl chains and multiple isomers with branch points at different car
Externí odkaz:
https://doaj.org/article/1feb5ed25790424086099f64e8f40f56
Autor:
Shiki Okamoto, Tatsuya Sato, Michihiro Tateyama, Haruaki Kageyama, Yuko Maejima, Masanori Nakata, Satoshi Hirako, Takashi Matsuo, Sanda Kyaw, Tetsuya Shiuchi, Chitoku Toda, Udval Sedbazar, Kumiko Saito, Nur Farehan Asgar, Boyang Zhang, Shigefumi Yokota, Kenta Kobayashi, Fabienne Foufelle, Pascal Ferré, Masamitsu Nakazato, Hiroaki Masuzaki, Seiji Shioda, Toshihiko Yada, Barbara B. Kahn, Yasuhiko Minokoshi
Publikováno v:
Cell Reports, Vol 22, Iss 3, Pp 706-721 (2018)
Food selection is essential for metabolic homeostasis and is influenced by nutritional state, food palatability, and social factors such as stress. However, the mechanism responsible for selection between a high-carbohydrate diet (HCD) and a high-fat
Externí odkaz:
https://doaj.org/article/90df534131bd4d7b9587b674521bbbf1
Autor:
Shawna L. McMillin, Erin C. Stanley, Luke A. Weyrauch, Jeffrey J. Brault, Barbara B. Kahn, Carol A. Witczak
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4913 (2021)
Denervation rapidly induces insulin resistance (i.e., impairments in insulin-stimulated glucose uptake and signaling proteins) in skeletal muscle. Surprisingly, whether this metabolic derangement is long-lasting is presently not clear. The main goal
Externí odkaz:
https://doaj.org/article/2897cecf57834917adce9aa30320ceed
Autor:
Archana Vijayakumar, Pratik Aryal, Jennifer Wen, Ismail Syed, Reema P. Vazirani, Pedro M. Moraes-Vieira, Joao Paulo Camporez, Molly R. Gallop, Rachel J. Perry, Odile D. Peroni, Gerald I. Shulman, Alan Saghatelian, Timothy E. McGraw, Barbara B. Kahn
Publikováno v:
Cell Reports, Vol 21, Iss 4, Pp 1021-1035 (2017)
Summary: Lower adipose-ChREBP and de novo lipogenesis (DNL) are associated with insulin resistance in humans. Here, we generated adipose-specific ChREBP knockout (AdChREBP KO) mice with negligible sucrose-induced DNL in adipose tissue (AT). Chow-fed
Externí odkaz:
https://doaj.org/article/01014948a8b042bc958c1e6672bd5820
Autor:
Carl Owen, Alicja Czopek, Abdelali Agouni, Louise Grant, Robert Judson, Emma K. Lees, George D. Mcilroy, Olga Göransson, Andy Welch, Kendra K. Bence, Barbara B. Kahn, Benjamin G. Neel, Nimesh Mody, Mirela Delibegović
Publikováno v:
PLoS ONE, Vol 7, Iss 5 (2012)
Externí odkaz:
https://doaj.org/article/373c9adebb3842baa9f57e05cfb4fb73
Autor:
Anna Santoro, Barbara B. Kahn
Publikováno v:
New England Journal of Medicine. 388:2071-2085
Autor:
Maria F. Rubin de Celis, Ruben Garcia-Martin, Ismail Syed, Jennifer Lee, Cristina Aguayo-Mazzucato, Susan Bonner-Weir, Barbara B. Kahn
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(47)
Senescence in pancreatic beta cells plays a major role in beta cell dysfunction, which leads to impaired glucose homeostasis and diabetes. Therefore, prevention of beta cell senescence could reduce the risk of diabetes. Treatment of nonobese diabetic
Autor:
Loren M, DeVito, Edward A, Dennis, Barbara B, Kahn, Gerald I, Shulman, Joseph L, Witztum, Sudeshna, Sadhu, Joseph, Nickels, Matthew, Spite, Susan, Smyth, Sarah, Spiegel
Publikováno v:
Ann N Y Acad Sci
Recent research has shed light on the cellular and molecular functions of bioactive lipids that go far beyond what was known about their role as dietary lipids. Bioactive lipids regulate inflammation and its resolution as signaling molecules. Genetic