Intestinal microbiota composition is predictive of radiotherapy-induced acute gastrointestinal toxicity in prostate cancer patientsResearch in context

Autor: Jacopo Iacovacci, Mara Serena Serafini, Barbara Avuzzi, Fabio Badenchini, Alessandro Cicchetti, Andrea Devecchi, Michela Dispinzieri, Valentina Doldi, Tommaso Giandini, Eliana Gioscio, Elisa Mancinelli, Barbara Noris Chiorda, Ester Orlandi, Federica Palorini, Luca Possenti, Miguel Reis Ferreira, Sergio Villa, Nadia Zaffaroni, Loris De Cecco, Riccardo Valdagni, Tiziana Rancati

Publikováno v: EBioMedicine, Vol 106, Iss , Pp 105246- (2024)

Summary: Background: The search for factors beyond the radiotherapy dose that could identify patients more at risk of developing radio-induced toxicity is essential to establish personalised treatment protocols for improving the quality-of-life of su

Externí odkaz: https://doaj.org/article/30e4e29616ee4652af26abb3792fa4bf

High weekly integral dose and larger fraction size increase risk of fatigue and worsening of functional outcomes following radiotherapy for localized prostate cancer

Autor: Nuradh Joseph, Alessandro Cicchetti, Alan McWilliam, Adam Webb, Petra Seibold, Claudio Fiorino, Cesare Cozzarini, Liv Veldeman, Renée Bultijnck, Valérie Fonteyne, Christopher J. Talbot, Paul R. Symonds, Kerstie Johnson, Tim Rattay, Maarten Lambrecht, Karin Haustermans, Gert De Meerleer, Rebecca M. Elliott, Elena Sperk, Carsten Herskind, Marlon Veldwijk, Barbara Avuzzi, Tommaso Giandini, Riccardo Valdagni, David Azria, Marie-Pierre Farcy Jacquet, Marie Charissoux, Ana Vega, Miguel E. Aguado-Barrera, Antonio Gómez-Caamaño, Pierfrancesco Franco, Elisabetta Garibaldi, Giuseppe Girelli, Cinzia Iotti, Vittotorio Vavassori, Jenny Chang-Claude, Catharine M. L. West, Tiziana Rancati, Ananya Choudhury

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

IntroductionWe hypothesized that increasing the pelvic integral dose (ID) and a higher dose per fraction correlate with worsening fatigue and functional outcomes in localized prostate cancer (PCa) patients treated with external beam radiotherapy (EBR

Externí odkaz: https://doaj.org/article/f2bb34992a8046558fc9d3a6f82986a3

Dosimetric Impact of Inter-Fraction Anatomical Changes in Carbon Ion Boost Treatment for High-Risk Prostate Cancer (AIRC IG 14300)

Autor: Stefania Russo, Rosalinda Ricotti, Silvia Molinelli, Filippo Patti, Amelia Barcellini, Edoardo Mastella, Andrea Pella, Chiara Paganelli, Giulia Marvaso, Matteo Pepa, Stefania Comi, Mattia Zaffaroni, Barbara Avuzzi, Tommaso Giandini, Emanuele Pignoli, Riccardo Valdagni, Guido Baroni, Federica Cattani, Mario Ciocca, Barbara Alicja Jereczek-Fossa, Ester Orlandi, Roberto Orecchia, Barbara Vischioni

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

Rectum and bladder volumes play an important role in the dose distribution reproducibility in prostate cancer adenocarcinoma (PCa) radiotherapy, especially for particle therapy, where density variation can strongly affect the dose distribution. We in

Externí odkaz: https://doaj.org/article/82cd3c70195c455ca222c981541ba209

External Validation of a Predictive Model for Acute Skin Radiation Toxicity in the REQUITE Breast Cohort

Autor: Tim Rattay, Petra Seibold, Miguel E. Aguado-Barrera, Manuel Altabas, David Azria, Gillian C. Barnett, Renée Bultijnck, Jenny Chang-Claude, Ananya Choudhury, Charlotte E. Coles, Alison M. Dunning, Rebecca M. Elliott, Marie-Pierre Farcy Jacquet, Sara Gutiérrez-Enríquez, Kerstie Johnson, Anusha Müller, Giselle Post, Tiziana Rancati, Victoria Reyes, Barry S. Rosenstein, Dirk De Ruysscher, Maria C. de Santis, Elena Sperk, Hilary Stobart, R. Paul Symonds, Begoña Taboada-Valladares, Ana Vega, Liv Veldeman, Adam J. Webb, Catharine M. West, Riccardo Valdagni, Christopher J. Talbot, REQUITE consortium, Yolande Lievens, Marc van Eijkeren, Piet Ost, Valérie Fonteyne, Christel Monten, Wilfried De Neve, Stephanie Peeters, Karin Haustermans, Caroline Weltens, Gilles Defraene, Maarten Lambrecht, Erik van Limberghen, Erik Briers, Celine Bourgier, Muriel Brengues, Roxana Draghici, Francoise Bons, Thomas Blaschke, Christian Weiß, Irmgard Helmbold, Christian Weißenberger, Petra Stegmaier, Johannes Claßen, Ulrich Giesche, Marie-Luise Sautter-Bihl, Burkhard Neu, Thomas Schnabel, Michael Ehmann, Benjamin Gauter-Fleckenstein, Carsten Herskind, Marlon Veldwijk, Jörg Schäfer, Tommaso Giandini, Marzia Franceschini, Claudia Sangalli, Barbara Avuzzi, Sara Morlino, Laura Lozza, Gabriele Pietro, Elena Delmastro, Elisabetta Garibaldi, Alessandro Cicchetti, Ben Vanneste, Bibiana Piqué-Leiva, Meritxel Molla, Alexandra Giraldo, Monica Ramos, Ramon Lobato-Busto, Paloma Sosa-Fajardo, Laura Torrado Moya, Isabel Dominguez-Rios, Irene Fajardo-Paneque, Patricia Calvo-Crespo, Ana Carballo, Paula Peleteiro, Olivia-Fuentes-Rios, Antonio Gomez-Caamano, Victoria Harrop, Debbie Payne, Manjusha Keni, Samuel Lavers, Simon Wright, Sridhar Thiagarajan, Luis Aznar-Garcia, Kiran Kancherla, Christopher Kent, Subramaniam Vasanthan, Donna Appleton, Monika Kaushik, Frances Kenny, Hazem Khout, Jaroslaw Krupa, Kelly V. Lambert, Simon Pilgrim, Sheila Shokuhi, Kalliope Valassiadou, Ion Bioangiu, Kufre Sampson, Ahmed Osman, Corinne Faivre-Finn, Karen Foweraker, Abigail Pascoe, Claire P. Esler, Tim Ward, Daniel S. Higginson, Richard G. Stock, Sheryl Green

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

Background: Acute skin toxicity is a common and usually transient side-effect of breast radiotherapy although, if sufficiently severe, it can affect breast cosmesis, aftercare costs and the patient's quality-of-life. The aim of this study was to deve

Externí odkaz: https://doaj.org/article/8c6dd513848e4d99a2a71215a83b3a38

Predictors of 2-Year Incidence of Patient-Reported Urinary Incontinence After Post-prostatectomy Radiotherapy: Evidence of Dose and Fractionation Effects

Autor: Andrea Bresolin, Elisabetta Garibaldi, Adriana Faiella, Domenico Cante, Vittorio Vavassori, Justina Magdalena Waskiewicz, Giuseppe Girelli, Barbara Avuzzi, Elisa Villa, Alessandro Magli, Barbara Noris Chiorda, Fernando Munoz, Giuseppe Sanguineti, Pietro Gabriele, Marco Gatti, Tiziana Rancati, Riccardo Valdagni, Nadia Di Muzio, Claudio Fiorino, Cesare Cozzarini

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

Objective: To investigate predictors of patient-reported urinary incontinence (PRUI) in the first 2 years after post-prostatectomy radiotherapy (PORT) with particular emphasis on possible dose-effect relationships.Patients and Methods: Two-hundred-th

Externí odkaz: https://doaj.org/article/ed4ce5d7d891471a857970e84b0d0dcd