Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Barbara Ardelt"'
Publikováno v:
Scopus-Elsevier
Onconase (Onc), a ribonuclease from oocytes of Northern Leopard frogs (Rana pipienss) is cytostatic and cytotoxic to a variety of tumor lines in vitro, inhibits growth of tumors in animal in vivo models and enhances sensitivity of tumor cells to a nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbdfe0eb551e099f67ae6604f24288b1
https://doi.org/10.4161/cc.7.20.6855
https://doi.org/10.4161/cc.7.20.6855
Autor:
Masamichi Ita, Zbigniew Darzynkiewicz, Barbara Ardelt, H. Dorota Halicka, Akira Kurose, Kuslima Shogen, Toshiki Tanaka
Publikováno v:
Scopus-Elsevier
Onconase (Onc), a ribonuclease from oocytes or early embryos of Northern Leopard frog (Rana pipiens), is cytostatic and cytotoxic to a variety of tumor lines in vitro, inhibits growth of tumors in animal in vivo models and is currently in Phase IIIb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::379ee3ecc5c2ee27806fe8771ece3f04
https://doi.org/10.4161/cbt.7.7.6172
https://doi.org/10.4161/cbt.7.7.6172
Autor:
Wojciech Ardelt, Cindy Schulenburg, Zbigniew Darzynkiewicz, Ulrich Arnold, Barbara Ardelt, Renate Ulbrich-Hofmann, Kuslima Shogen
Publikováno v:
Scopus-Elsevier
Onconase (ONC) is a cytotoxic ribonuclease of the pancreatic ribonuclease A super-family isolated from oocytes or early embryos of the Northern leopard frog ( Rana pipiens ). It shows anticancer activity and currently is in Phase IIIb clinical trial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c78a7800aa8fcdf2c401ca848c39b0a8
https://doi.org/10.4161/cbt.6.8.4423
https://doi.org/10.4161/cbt.6.8.4423
Autor:
Zbigniew Darzynkiewicz, Barbara Ardelt, James A. Flint, Thomas Coradetti, Zhili Huang, Wlodek Mandecki, Hanan Davidowitz, Zhuying Wang, Xin Lin, Wesley M. Kopacka
Publikováno v:
Cytometry Part A. :1097-1105
An electronic radio frequency (RF) microchip, the microtransponder (MTP), has been developed as a platform for assays in the fields of genomics and proteomics. Upon activation by light, each MTP provides a unique RF identification (ID) signal that ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::833c871b22c35f2b885a8c8a9a03bfbe
https://doi.org/10.1002/cyto.a.20344
https://doi.org/10.1002/cyto.a.20344
Publikováno v:
Cytometry. 49:83-89
Background One of the hallmarks of apoptosis is activation of tissue transglutaminase (Tgase; also called transglutaminase type 2 [TGase 2]). Its activation causes cross-linking of cytoplasmic proteins, making them insoluble and presumably less immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cbd85b67836cb36d9884b61d49308c8
https://doi.org/10.1002/cyto.10150
https://doi.org/10.1002/cyto.10150
Publikováno v:
Biochemical Pharmacology. 63:625-634
Recently, accumulated statistical data indicate the protective effect of caffeine consumption against several types of cancer diseases. There are also reports about protective effect of caffeine and other xanthines against tumors induced by polycycli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::befe5b52e9c3c5d8d9737469354e91e1
https://doi.org/10.1016/s0006-2952(01)00904-2
https://doi.org/10.1016/s0006-2952(01)00904-2
Autor:
Piotr Smolewski, Masamichi Ita, Myron R. Melamed, Barbara Ardelt, Wojciech Gorczyca, Zbigniew Darzynkiewicz, Jerzy Grabarek
Publikováno v:
Cytometry. 45:206-213
Background Various attributes of nucleoli, including abundance of the nucleolar product (rRNA), correlate with cell-proliferative status and are useful markers for tumor diagnosis and prognosis. However, there is a paucity of methods that can quantit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9f7d6a3b3ca04f180773e897fb72cdd
https://doi.org/10.1002/1097-0320(20011101)45:3<206::aid-cyto1164>3.0.co
https://doi.org/10.1002/1097-0320(20011101)45:3<206::aid-cyto1164>3.0.co
Autor:
Xun Li, Zbigniew Darzynkiewicz, Barbara Ardelt, K Shogen, Wojciech Ardelt, SM Mikulski, Gloria Juan, Abraham Mittelman
Publikováno v:
Scopus-Elsevier
Onconase is a 12 kDa protein homologous to pancreatic RNase A isolated from amphibian oocytes which shows cytostatic and cytotoxic activity in vitro, inhibits growth of tumors in mice and is in phase III clinical trials. The present study was aimed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b44d34c9f2ebfd50deb005bba7c353e
https://doi.org/10.1038/sj.leu.2401100
https://doi.org/10.1038/sj.leu.2401100
Publikováno v:
Cytometry. 25:1-13
Cyclins are key components of the cell cycle progression machinery. They activate their partner cyclin-dependent kinases (CDKs) and possibly target them to respective substrate proteins within the cell. CDK-mediated phosphorylation of specific sets o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085396c3344e4f2ff7b172180ea39961
https://doi.org/10.1002/(sici)1097-0320(19960901)25:1<1::aid-cyto1>3.0.co
https://doi.org/10.1002/(sici)1097-0320(19960901)25:1<1::aid-cyto1>3.0.co
Publikováno v:
Journal of Cellular Physiology. 158:535-544
Staurosporine (SSP) is an inhibitor of a variety of protein kinases with an especially high affinity towards protein kinase C. Whereas SSP has been shown to halt the cell cycle progression of various normal, nontransformed cell types in G1, most viru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a7b1396c215be47367db7ba8274253
https://doi.org/10.1002/jcp.1041580320
https://doi.org/10.1002/jcp.1041580320