Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Barbara A. Scofield"'
Autor:
Ping-Chang Kuo, Wen-Tsan Weng, Barbara A. Scofield, Hallel C. Paraiso, I-Chen Ivorine Yu, Jui-Hung Jimmy Yen
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Cerebral ischemic stroke accounts for more than 80% of all stroke cases. During cerebral ischemia, reactive oxygen species produced in the ischemic brain induce oxidative stress and inflammatory responses. Nrf2 is a transcription factor responsible f
Externí odkaz:
https://doaj.org/article/a515f33d398a41c08b0411ea5fdd6163
Autor:
Ping-Chang Kuo, Wen-Tsan Weng, Barbara A. Scofield, Hallel C. Paraiso, Paul Bojrab, Brandon Kimes, I-Chen Ivorine Yu, Jui-Hung Jimmy Yen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Tissue plasminogen activator (tPA) is the only FDA-approved drug for the treatment of ischemic stroke. Delayed tPA administration is associated with increased risks of blood-brain barrier (BBB) disruption and hemorrhagic transformation. Studies have
Externí odkaz:
https://doaj.org/article/f4f409a46d524d2394ad670542f2bf1c
Autor:
Wen-Tsan Weng, Ping-Chang Kuo, Dennis A. Brown, Barbara A. Scofield, Destin Furnas, Hallel C. Paraiso, Pei-Yu Wang, I-Chen Yu, Jui-Hung Yen
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-18 (2021)
Abstract Background Multiple sclerosis (MS) is a progressive autoimmune disease characterized by the accumulation of pathogenic inflammatory immune cells in the central nervous system (CNS) that subsequently causes focal inflammation, demyelination,
Externí odkaz:
https://doaj.org/article/a771c0f71f3943a4a136c3a6e9473de5
Autor:
Wen-Tsan Weng, Ping-Chang Kuo, Barbara A. Scofield, Hallel C. Paraiso, Dennis A. Brown, I-Chen Yu, Jui-Hung Yen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Ischemic stroke is caused by a sudden reduction in cerebral blood flow that subsequently induces a complex cascade of pathophysiological responses, leading to brain inflammation and irreversible infarction. 4-ethylguaiacol (4-EG) is reported to suppr
Externí odkaz:
https://doaj.org/article/ea1cb58108264ac4ab5ca4a262b23824
Autor:
Ping-Chang Kuo, Wen-Tsan Weng, Barbara A. Scofield, Hallel C. Paraiso, Dennis A. Brown, Pei-Yu Wang, I-Chen Yu, Jui-Hung Yen
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-15 (2020)
Abstract Background Inflammatory stimuli induce immunoresponsive gene 1 (IRG1) expression that in turn catalyzes the production of itaconate from the tricarboxylic acid cycle. Itaconate has recently emerged as a regulator of immune cell functions, es
Externí odkaz:
https://doaj.org/article/5aa3493b33554c2595ce0a39c9e43089
Autor:
Hallel C. Paraiso, Xueqian Wang, Ping-Chang Kuo, Destin Furnas, Barbara A. Scofield, Fen-Lei Chang, Jui-Hung Yen, I-Chen Yu
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Brain microvasculature forms a specialized structure, the blood-brain barrier (BBB), to maintain homeostasis and integrity of the central nervous system (CNS). The BBB dysfunction is emerging as a critical contributor to multiple neurological disorde
Externí odkaz:
https://doaj.org/article/3e11009792f844cda3e2560db913c467
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 1 (2016)
BackgroundStroke is a leading cause of death in the world. In >80% of strokes, the initial acute phase of ischemic injury is due to the occlusion of a blood vessel resulting in severe focal hypoperfusion, excitotoxicity, and oxidative damage. Interfe
Externí odkaz:
https://doaj.org/article/6f9b41ae78904edeab09dcd26b363e40
Publikováno v:
Proceedings of IMPRS. 5
Background: Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Pathogenic T cells, such as Th1 and Th17, infiltrate the CNS, resulting in neuroinflammation, demyelination and axonal damage. Th1 activates microglia (
Autor:
Kristopher D. Bosi, Jui-Hung Yen, Destin Furnas, Alexander J. Intriago, Ping-Chang Kuo, I-Chen Yu, Wen-Tsan Weng, Hallel C. Paraiso, Barbara A. Scofield
Publikováno v:
Blood Adv
Tissue plasminogen activator (tPA) is the only US Food and Drug Administration (FDA)–approved drug for ischemic stroke. However, delayed tPA administration is associated with increased risk of blood-brain barrier (BBB) disruption and hemorrhagic tr
Autor:
Ping-Chang Kuo, Wen-Tsan Weng, Barbara A. Scofield, Destin Furnas, Hallel C. Paraiso, I-Chen Yu, Jui-Hung Yen
Publikováno v:
The Journal of Immunology. 208:111.02-111.02
Inflammatory stimuli induce immunoresponsive gene 1 (IRG1) expression that in turn catalyzes the production of itaconate through diverting cis-aconitate away from the tricarboxylic acid cycle. The immunoregulatory effect of IRG1/itaconate axis has be