Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Barbara A. Schweitzer"'
Publikováno v:
Linear Algebra and its Applications. 557:84-104
We study the eigenvalues of the unique connected anti-regular graph $A_n$. Using Chebyshev polynomials of the second kind, we obtain a trigonometric equation whose roots are the eigenvalues and perform elementary analysis to obtain an almost complete
Autor:
Barbara A. Schweitzer, Atli Thorarensen, Michael S. Davies, Steve R. Turner, Matthew James Pelc, James R. Kiefer, Brenda L. Case, Christie L. Funckes-Shippy, Jacqueline E. Day, Fengmei Hua, Dice Tom, William M. Abraham, Bradley E. Neal, John I. Trujillo, Joseph B. Moon, Blake Tanisha Danielle Rowe, Wei Huang, Craig D. Wegner, Dean Welsch, Chris P. Carron, Anup Zutshi, Bruce C. Hamper, Chad J. Warren, Rhonda S. Woerndle, Christine M. Kornmeier, Vickie M. Dilworth, Melanie L. Williams, Martin E. Dowty, Olson Kirk Lang, Melissa R. Radabaugh, Becky L. Hood, Jerry Z. Yang, Douglas C. Rohrer, Gina M. Jerome, Christine P. Bono
Publikováno v:
ACS Medicinal Chemistry Letters. 1:59-63
Hematopoietic prostaglandin D synthase (HPGDS) is primarly expressed in mast cells, antigen-presenting cells, and Th-2 cells. HPGDS converts PGH2 into PGD2, a mediator thought to play a pivotal role in airway allergy and inflammatory processes. In th
Autor:
Hayat K. Rahman, Tenbrink Ruth E, Barbara A. Schweitzer, Rita M. Huff, Steven W. Kortum, Gopichand Yalamanchili, Rhonda M. Lachance, Ennis Michael D
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5919-5923
Herein we describe the design and synthesis of a novel series of potent thienopyrimidine P2Y12 inhibitors and the negative impact protein binding has on the inhibition of platelet aggregation.
Autor:
William L. Neumann, Hayat K. Rahman, Carrie L. Kusturin, Lanny S. Liebeskind, Jiri Srogl, Barbara A. Schweitzer, Kirby Sample
Publikováno v:
Organic Letters. 5:4349-4352
[reaction: see text] A general demonstration of orthogonal selectivity of the Liebeskind-Srogl cross-coupling protocol compared to the Suzuki-Miyaura and Stille variants is reported.
Autor:
Salvatore Profeta, Robert C. Chott, Claire A. CaJacob, Paul J. Loida, Shridhar G. Hegde, Philip D. Mosier, Barbara A. Schweitzer, Elizabeth M. Collantes
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1743-1746
Imidazole glycerol phosphate dehydratase (IGPD) has become an attractive target for herbicide discovery since it is present in plants and not in mammals. Currently no knowledge is available on the 3-D structure of the IGPD active site. Therefore, we
Autor:
Paul J. Loida, Rebecca L. Thompson-Mize, Claire A. CaJacob, Barbara A. Schweitzer, Shridhar G. Hegde
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2053-2058
We describe the synthesis and enzymatic activity of a library of beta-carboxamido phosphonates as inhibitors of imidazole glycerol phosphate dehydratase (IGPD). Biological results suggest the presence of an enzymatic interaction site not previously o
Publikováno v:
Angewandte Chemie. 108:834-837
Autor:
Sarah E. Smith, Scott J. Bowen, Scott A. Long, David Beidler, Marvin J. Meyers, Atli Thorarensen, Heather M. Madsen, Joseph J. McDonald, Susan Foltin, Barbara A. Schweitzer, Tenbrink Ruth E, Jane L. Wang, Mark C. Walker, Matthew James Pelc
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(21)
Herein we report the identification of two new fatty acid amide hydrolase (FAAH) inhibitor lead series with FAAH k(inact)/K(i) potency values greater than 1500M(-1)s(-1). The two novel spirocyclic cores, 7-azaspiro[3.5]nonane and 1-oxa-8-azaspiro[4.5
Autor:
Sarah E. Smith, Marvin J. Meyers, Young-Sun Yang, Joseph J. McDonald, David Beidler, Atli Thorarensen, Matthew James Pelc, Jeanne M. Rumsey, Mark V. Wilcox, Satwik Kamtekar, Scott A. Long, Scott J. Bowen, Jane L. Wang, Mark C. Walker, Susan Foltin, Barbara A. Schweitzer
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(21)
Fatty acid amide hydrolase (FAAH) is an integral membrane serine hydrolase responsible for the degradation of fatty acid amide signaling molecules such as endocannabinoid anandamide (AEA), which has been shown to possess cannabinoid-like analgesic pr
Autor:
Barbara A. Schweitzer, Tad H. Koch
Publikováno v:
Journal of the American Chemical Society. 115:5440-5445
Reduction of 5-iminodaunomycin with dithionite in anaerobic methanol followed by lowering the pH to 3 and saturating with air led to deamination without glycosidic cleavage to yield 89% 5-deoxydaunomycin. An intermediate observed during the reaction