Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Barbara A. Mysona"'
Autor:
Jing Zhao, Rajalakshmi Veeranan-Karmegam, Frederick C. Baker, Barbara A. Mysona, Pritha Bagchi, Yutao Liu, Sylvia B. Smith, Graydon B. Gonsalvez, Kathryn E. Bollinger
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Sigma 1 Receptor (S1R) is a therapeutic target for a wide spectrum of pathological conditions ranging from neurodegenerative diseases to cancer and COVID-19. S1R is ubiquitously expressed throughout the visceral organs, nervous, immune and cardiovasc
Externí odkaz:
https://doaj.org/article/5fa23cfe8ef44a56808b7703df49b7a6
Autor:
Barbara A. Mysona, Jing Zhao, Oceane De Greef, August Beisel, Parth A. Patel, Lindsay Berman, Sylvia B. Smith, Kathryn Bollinger
Publikováno v:
Experimental eye research. 226
Glaucoma is a worldwide leading cause of irreversible blindness. Standard treatments lower intraocular pressure (IOP). Novel treatments to prevent optic nerve (ON) degeneration are needed. Here, we investigate the hypothesis that sigma-1 receptor (S1
Autor:
Jing Zhao, Barbara A Mysona, Jing Wang, Graydon B Gonsalvez, Sylvia B Smith, Kathryn E Bollinger
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184421 (2017)
The sigma 1 receptor (S1R) is a unique transmembrane protein that has been shown to regulate neuronal differentiation and cellular survival. It is expressed within several cell types throughout the nervous system and visceral organs, including neuron
Externí odkaz:
https://doaj.org/article/5fe73468558b409ba1b85fba2e2721ea
Autor:
Jing Zhao, Rajalakshmi Veeranan-Karmegam, Frederick C. Baker, Barbara A. Mysona, Pritha Bagchi, Yutao Liu, Sylvia B. Smith, Graydon B. Gonsalvez, Kathryn E. Bollinger
Sigma 1 Receptor (S1R) is a therapeutic target for a wide spectrum of pathological conditions ranging from neurodegenerative diseases to cancer and COVID-19. S1R is ubiquitously expressed throughout the visceral organs, nervous, immune and cardiovasc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffe72f9fdb8fd956e80df27ae7541698
https://doi.org/10.1101/2022.06.22.497210
https://doi.org/10.1101/2022.06.22.497210
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 2, Iss , Pp - (2015)
Accumulation of the nerve growth factor precursor (proNGF) and its receptor p75NTR have been associated with several neurodegenerative diseases in both brain and retina. However, whether proNGF contributes to microvascular degeneration remain unexplo
Externí odkaz:
https://doaj.org/article/e24c2c97df4a432a993ffd2fda981ed8
Autor:
Bobby Thomas, Kathryn E. Bollinger, Jing Wang, Jing Zhao, Alan Saul, Manuj Ahuja, N. Lambert, Xuezhi Cui, Irina G. Gazaryan, Barbara A. Mysona, Sylvia B. Smith, Soumya Navneet
Publikováno v:
Free Radical Biology and Medicine. 134:604-616
Sigma 1 receptor (Sig1R), a putative molecular chaperone, has emerged as a novel therapeutic target for retinal degenerative disease. Earlier studies showed that activation of Sig1R via the high-affinity ligand (+)-pentazocine ((+)-PTZ) induced profo
Publikováno v:
Progress in Retinal and Eye Research. 67:130-149
Retinal degenerative diseases are major causes of untreatable blindness worldwide and efficacious treatments for these diseases are sorely needed. A novel target for treatment of retinal disease is the transmembrane protein Sigma 1 Receptor (Sig1R).
Publikováno v:
Investigative Opthalmology & Visual Science. 63:1
Sigma 1 receptor (S1R) is expressed in retinal ganglion cells (RGCs) and astrocytes, and its activation is neuroprotective. We evaluated the contribution of S1R within optic nerve head astrocytes (ONHAs) to growth and survival of RGCs in vitro.Wild-t
Autor:
Mohammed M H Al-Gayyar, Barbara A Mysona, Suraporn Matragoon, Mohammed A Abdelsaid, Mona F El-Azab, Ahmed Y Shanab, Yonju Ha, Sylvia B Smith, Kathryn E Bollinger, Azza B El-Remessy
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54692 (2013)
Our previous studies showed positive correlation between accumulation of proNGF, activation of RhoA and neuronal death in diabetic models. Here, we examined the neuroprotective effects of selective inhibition of RhoA kinase in the diabetic rat retina
Externí odkaz:
https://doaj.org/article/0c89936eb4594b909d45a4b4e0347303
Autor:
Chunfang Gu, Anthony N. Kuo, Zhong Chen, Hongfang Yu, Alice Liu, Amy Estes, Hongyan Xu, Mariam Lofty Khaled, Abdulrahman Al-Muammar, Louise F. Porter, Stephen B. Shears, Jing Wang, Yutao Liu, Mitchell A. Watsky, Khaled K. Abu-Amero, Yaron S. Rabinowitz, Jerome I. Rotter, Yelena Bykhovskaya, Xiaowen Lu, Ryan P. McNabb, Sylvia B. Smith, Emily J. Parker, Xiaohui Li, Barbara A. Mysona, Michelle Drewry
Publikováno v:
Scientific reports, vol 9, iss 1
SCIENTIFIC REPORTS
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
SCIENTIFIC REPORTS
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Keratoconus (KC) is the most common corneal ectatic disorder affecting >300,000 people in the US. KC normally has its onset in adolescence, progressively worsening through the third to fourth decades of life. KC patients report significant impaired v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a217a385dc4efc5e72cf32f9a7056f
https://escholarship.org/uc/item/04t3x4s5
https://escholarship.org/uc/item/04t3x4s5