Výsledky vyhledávání - "Barbara A. Koop"

Akademický článek

New targeted approaches for epigenetic age predictions

Autor: Yang Han, Julia Franzen, Thomas Stiehl, Michael Gobs, Chao-Chung Kuo, Miloš Nikolić, Jan Hapala, Barbara Elisabeth Koop, Klaus Strathmann, Stefanie Ritz-Timme, Wolfgang Wagner

Publikováno v: BMC Biology, Vol 18, Iss 1, Pp 1-15 (2020)

Abstract Background Age-associated DNA methylation changes provide a promising biomarker for the aging process. While genome-wide DNA methylation profiles enable robust age-predictors by integration of many age-associated CG dinucleotides (CpGs), the

Externí odkaz: https://doaj.org/article/94093329efc745ce9dd69232bf5409dc

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Evidence for differences in DNA methylation between Germans and Japanese

Autor: Simon B. Eickhoff, M. Takayama, J. Blum, Wolfgang Wagner, Petra Böhme, Julia Becker, Stefanie Ritz-Timme, Tanju Gündüz, Barbara Elisabeth Koop, Alexandra Reckert

Publikováno v: International journal of legal medicine 136(2), 405-413 (2022). doi:10.1007/s00414-021-02736-3
International journal of legal medicine 136, 405–413 (2022). doi:10.1007/s00414-021-02736-3

International journal of legal medicine 136(2), 405-413 (2022). doi:10.1007/s00414-021-02736-3
Published by Springer, Berlin ; Heidelberg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3108202855c4ac055200f777ebd341e6
https://doi.org/10.1007/s00414-021-02736-3

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Molecular and morphological findings in a sample of oral surgery patients: What can we learn for multivariate concepts for age estimation?

Autor: Lisa Küppers, Stefanie Ritz-Timme, Tanju Gündüz, Petra Böhme, Wolfgang Wagner, Felix Mayer, Tatjana Siahaan, Julia Becker, Barbara Elisabeth Koop, Alexandra Reckert, Simon B. Eickhoff

Publikováno v: Journal of forensic sciences 66(4), 1524-1532 (2021). doi:10.1111/1556-4029.14704

It has already been proposed that a combined use of different molecular and morphological markers of aging in multivariate models may result in a greater accuracy of age estimation. However, such an approach can be complex and expensive, and not ever

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3412f8581a4477cabcddaae731818d5
https://pubmed.ncbi.nlm.nih.gov/33942892

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Postmortem age estimation via DNA methylation analysis in buccal swabs from corpses in different stages of decomposition—a 'proof of principle' study

Autor: Stefanie Ritz-Timme, Judith Schaffrath, Wolfgang Wagner, Tanju Gündüz, Julia Becker, Jacqueline Blum, Barbara Elisabeth Koop, Yang Han, Petra Boehme, Felix Mayer

Publikováno v: International journal of legal medicine 135(1), 167-173 (2021). doi:10.1007/s00414-020-02360-7
International Journal of Legal Medicine

International journal of legal medicine 135(1), 167-173 (2021). doi:10.1007/s00414-020-02360-7
Published by Springer, Berlin ; Heidelberg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34de32f175d159161fa806d95582e67c

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Epigenetic clocks may come out of rhythm—implications for the estimation of chronological age in forensic casework

Autor: Julia Becker, Yang Han, Alexandra Reckert, Stefanie Ritz-Timme, Barbara Elisabeth Koop, Wolfgang Wagner

Publikováno v: International journal of legal medicine 134(6), 2215-2228 (2020). doi:10.1007/s00414-020-02375-0
International Journal of Legal Medicine

International journal of legal medicine 134(6), 2215-2228 (2020). doi:10.1007/s00414-020-02375-0
Published by Springer, Berlin ; Heidelberg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dcfd466a04409f2a82e3e52b3ba0707
https://publications.rwth-aachen.de/record/814080

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Split Tolerance in a Novel Transgenic Model of Autoimmune Myasthenia Gravis

Autor: Sue Stacy, Keith A. Krolick, Ellen Kraig, Bruce E. Gelb, Anthony J. Infante, Katherine A. Wall, Jolene J. Windle, Barbara A. Koop

Publikováno v: The Journal of Immunology. 169:6570-6579

Because it is one of the few autoimmune disorders in which the target autoantigen has been definitively identified, myasthenia gravis (MG) provides a unique opportunity for testing basic concepts of immune tolerance. In most MG patients, Abs against

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968af585f1b3ca70cdc485c19495976d
https://doi.org/10.4049/jimmunol.169.11.6570

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Immortalized murine osteoblasts derived from BMP 2-T-antigen expressing transgenic mice

Autor: Stephen E. Harris, Jolene J. Windle, Marie A. Harris, Nandini Ghosh-Choudhury, Gregory R. Mundy, John M. Wozney, Daniel L. Guerrero, Barbara A. Koop

Publikováno v: Endocrinology. 137:331-339

Osteoblast cell lines capable of undergoing bone formation in vitro would provide useful models for understanding gene expression during bone cell differentiation. To that end, transgenic mice were produced using a 2.9-kilobase bone morphogenetic pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc57cdf0a01875f368a8f8e930c7697f
https://doi.org/10.1210/endo.137.1.8536632

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Osteoclasts formed by measles virus-infected osteoclast precursors from hCD46 transgenic mice express characteristics of pagetic osteoclasts

Autor: Noriyoshi Kurihara, Sakamuri V. Reddy, Gary Landucci, G. David Roodman, Barbara A. Koop, Cheikh Menaa, Jolene J. Windle, Donald N. Forthal

Publikováno v: Endocrinology. 142(7)

Pagetic osteoclasts (OCLs) are abnormal in size and contain paramyxoviral-like nuclear inclusions that cross-react with antibodies to measles virus (MV). However, the role that MV infection plays in Paget's disease is unknown, because no animal model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ac2a377ced646b6ce61da61e947d48
https://pubmed.ncbi.nlm.nih.gov/11416009

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Immortalization of osteoclast precursors by targeting Bcl -XL and Simian virus 40 large T antigen to the osteoclast lineage in transgenic mice

Autor: G. D. Roodman, Brendan F. Boyce, T. A. Hentunen, Katri Selander, Hoyeon Chung, Deborah L. Galson, Noriyoshi Kurihara, Jolene J. Windle, Rowena D. Devlin, H.-R. Park, Barbara A. Koop, Sakamuri V. Reddy, S. R. Goldring, Mark Dallas

Publikováno v: The Journal of clinical investigation. 102(1)

Cellular and molecular characterization of osteoclasts (OCL) has been extremely difficult since OCL are rare cells, and are difficult to isolate in large numbers. We used the tartrate-resistant acid phosphatase promoter to target the bcl-XL and/or Si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8cc6e2d5a69dd671fe1bc7f48c523c
https://pubmed.ncbi.nlm.nih.gov/9649561

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Establishment of an osteocyte-like cell line, MLO-Y4

Autor: Lynda F. Bonewald, Gregory R. Mundy, Yoichi Kato, Barbara A. Koop, Jolene J. Windle

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 12(12)

Although osteocytes are the most abundant cells in bone, their functional role remains unclear. In part, this is due to lack of availability of osteocyte cell lines which can be studied in vitro. Since others have shown that cell lines can be readily

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9a49bfe662d617d6bf39889ac69a294
https://pubmed.ncbi.nlm.nih.gov/9421234

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