Transforming Growth Factor (TGF) β and Endometrial Vascular Maturation

Autor: Qinsheng Lu, Dingqian Sun, Sourima Biswas Shivhare, Huomei Hou, Judith N. Bulmer, Barbara A. Innes, Dharani K. Hapangama, Gendie E. Lash

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Appropriate growth and development of the endometrium across the menstrual cycle is key for a woman’s quality of life and reproductive well-being. Recurrent pregnancy loss (RPL) and heavy menstrual bleeding (HMB) affect a significant proportion of

Externí odkaz: https://doaj.org/article/6fad0c9136f546219273df2c6434a7f8

Platelet-derived growth factor BB is reduced in endometrial endothelial cells of women with abnormal uterine bleeding-endometrial disorder

Autor: Sourima Biswas Shivhare, Qinsheng Lu, Dingqian Sun, Huomei Hou, Judith N. Bulmer, Barbara A. Innes, Dharani K. Hapangama, Gendie E. Lash

Publikováno v: Reproductive biomedicine online. 45(3)

What is the expression pattern of platelet-derived growth factor BB (PDGF-BB), and its receptors, across the menstrual cycle in healthy control women and those with abnormal uterine bleeding-endometrial disorder (AUB-E)?Immunohistochemical staining f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a9f86e413ea5220e4056bebb44f9e26
https://pubmed.ncbi.nlm.nih.gov/35739007

Bile acid receptor agonists in primary biliary cholangitis: Regulation of the cholangiocyte secretome and downstream T cell differentiation

Autor: Benjamin J. M. Millar, John A. Kirby, Barbara A. Innes, Rachel E. Etherington, John G. Brain, David Jones

Publikováno v: FASEB bioAdvances

Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease. Approximately 30% of patients do not respond to therapy with ursodeoxycholic acid (UDCA). Previous studies have implicated increased senescence of cholangiocytes in patients who

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91fa8e90d871e8200915997412cad4b2
https://doi.org/10.1096/fba.2018-00046

Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2

Autor: Katrina M Wood, Stephania Bitetti, Mohammed Zarhrate, Rafiqul Hussain, Vicky Brocklebank, Meghan Acres, Vincent Bondet, Ruyue Sun, Tracy A Briggs, Rui Chen, John H. Livingston, Richard E. Randall, Robert Wynn, Claire L. Harris, Darragh Duffy, Cécile Fourrage, Florian Gothe, Christopher J A Duncan, Sophie Hambleton, Stephen M. Hughes, Karin R. Engelhardt, Julija Pavaine, Leo A. H. Zeef, Jonathan Coxhead, Dan F. Young, Yanick J. Crow, Aneta Mikulasova, Victoria G. Shuttleworth, Bronte M. Corner, Gillian I. Rice, Edmund Cheesman, Barbara A. Innes, Ronnie Wright, David J. Kavanagh, Angela Grainger, Simon C. Lovell, Andrew J. Skelton, Benjamin J. Thompson

Publikováno v: Rice, G, Lovell, S, Pavaine, J, Wright, R, Zeef, L, Hambleton, S, Briggs, T & et al. 2019, ' Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2 ', Science Immunology, vol. 4, no. 42, eaav7501 . https://doi.org/10.1126/sciimmunol.aav7501
Duncan, C J A, Thompson, B, Chen, R, Rice, G I, Gothe, F, Young, D F, Lovell, S C, Shuttleworth, V G, Brocklebank, V, Corner, B, Skelton, A J, Bondet, V, Coxhead, J, Duffy, D, Fourrage, C, Livingston, J H, Pavaine, J, Cheesman, E, Bitetti, S, Grainger, A, Acres, M, Innes, B A, Mikulasova, A, Sun, R, Hussain, R, Wright, R, Wynn, R, Zarhrate, M, Zeef, L A H, Wood, K M, Hughes, S M, Harris, C L, Engelhardt, K R, Crow, Y, Randall, R E, Kavanagh, D, Hambleton, S & Briggs, T A 2019, ' Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2 ', Science Immunology . https://doi.org/10.1126/sciimmunol.aav7501
Science Immunology
Science Immunology, 2019, 4 (42), pp.eaav7501. ⟨10.1126/sciimmunol.aav7501⟩
Science Immunology, American Association for the Advancement of Science, 2019, 4 (42), pp.eaav7501. ⟨10.1126/sciimmunol.aav7501⟩

International audience; Excessive type I interferon (IFNα/β) activity is implicated in a spectrum of human disease, yet its direct role remains to be conclusively proven. We investigated two siblings with severe early-onset autoinflammatory disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75b99ad822c9b4f4b821ead0cffb9e2
https://pure.manchester.ac.uk/ws/files/149146089/aav7501_ArticleContent_preedit_CD_clean.docx

Décodage de l'hématopoïèse fétale hépatique humaine

Autor: Ben Millar, Laura Jardine, Rachel Rowell, Gary Reynolds, Sarah A. Teichmann, Anindita Roy, Orit Rozenblatt-Rosen, Emily Stephenson, Elisa Laurenti, Michal Slyper, Issac Goh, Aviv Regev, Frankie Greig, Lira Mamanova, Orr Ashenberg, Monika S. Kowalczyk, Barbara A. Innes, Jong-Eun Park, David McDonald, Berthold Göttgens, Corina Moldovan, Kile Green, Matthew D. Young, Danielle Dionne, Peter D. Carey, Irene Roberts, Mirjana Efremova, Zhichao Miao, Rachel A. Botting, Alain Chédotal, Simone Webb, Bo Li, Elizabeth Poyner, Steven Lisgo, Marcin Tabaka, Peter Vegh, Andrew Fuller, Yorick Gitton, Roser Vento-Tormo, Susan Lindsay, David Dixon, Sam Behjati, Meghan Acres, Alexandra-Chloé Villani, Michael J. T. Stubbington, Jaume Bacardit, Emily Calderbank, Dorin-Mirel Popescu, Daniel Maunder, Krzysztof Polanski, James Fletcher, Michael W. Mather, Kerstin B. Meyer, Timothy L. Tickle, Andrew Filby, Muzlifah Haniffa

Publikováno v: Nature
Nature, Nature Publishing Group, 2019, 574, pp.365-371. ⟨10.1038/s41586-019-1652-y⟩
Nature, Nature Publishing Group, 2019, 574 (7778), pp.365-371. ⟨10.1038/s41586-019-1652-y⟩

International audience; Definitive haematopoiesis in the fetal liver supports self-renewal anddifferentiation of haematopoietic stem cells and multipotent progenitors(HSC/MPPs) but remains poorly defined in humans. Here, using single-celltranscriptom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd2c8813ac4ea92ac6e1ca1e722aab2
https://www.repository.cam.ac.uk/handle/1810/297663