Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Barbara A. Guinn"'
Publikováno v:
Onco, Vol 4, Iss 2, Pp 87-100 (2024)
Lung cancer (LC) is one of the leading causes of cancer-related deaths. Pulmonary nodules are one of the risk factors, and their discovery rate has been increasing due to enhanced performance of chest CT scans, but more than 90% are non-malignant, ca
Externí odkaz:
https://doaj.org/article/1aa2966e2fc24c338e9d89c53478eaf6
Autor:
Jeanette M. Rotchell, Chloe Austin, Emma Chapman, Charlotte A. Atherall, Catriona R. Liddle, Timothy S. Dunstan, Ben Blackburn, Andrew Mead, Kate Filart, Ellie Beeby, Keith Cunningham, Jane Allen, Hannah Draper, Barbara-ann Guinn
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 274, Iss , Pp 116208- (2024)
Microplastics (MPs) are found in all environments, within the human food chain, and have been recently detected in several human tissues. The objective herein was to undertake an analysis of MP contamination in human urine samples, from healthy indiv
Externí odkaz:
https://doaj.org/article/32254a11143e47fe9be2670ef9e408ac
Publikováno v:
eJHaem, Vol 3, Iss 3, Pp 596-608 (2022)
Abstract Recent studies have shown that short non‐coding RNAs, known as microRNAs (miRNAs) and their dysregulation, are implicated in the pathogenesis of acute myeloid leukaemia (AML). This is due to their role in the control of gene expression in
Externí odkaz:
https://doaj.org/article/d4adf5da03644ac7909d6a3690bca915
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Endogenous metals are required for all life, orchestrating the action of diverse cellular processes that are crucial for tissue function. The dynamic wound healing response is underpinned by a plethora of such cellular behaviours, occurring in a time
Externí odkaz:
https://doaj.org/article/3e1ec66e61da4aec9b2c5202d7465c82
Autor:
Viktoriya B. Boncheva, Michael Linnebacher, Said Kdimati, Hannah Draper, Laurence Orchard, Ken I. Mills, Gerald O’Sullivan, Mark Tangney, Barbara-ann Guinn
Publikováno v:
Biomolecules, Vol 12, Iss 8, p 1058 (2022)
A Crohn’s-like lymphoid reaction (CLR) is observed in about 15% of colorectal cancer (CRC) patients and is associated with favourable outcomes. To identify the immune targets recognised by CRC CLR patient sera, we immunoscreened a testes cDNA libra
Externí odkaz:
https://doaj.org/article/c364a480018545e4a16d08b5ea91e6f6
Autor:
Wioletta Dolińska, Hannah Draper, Lara Othman, Chloe Thompson, Samantha Girvan, Keith Cunningham, Jane Allen, Alan Rigby, Kevin Phillips, Barbara-ann Guinn
Publikováno v:
F&S Reviews. 4:116-130
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3788ca190657973718579e48c8de512f
https://doi.org/10.1016/j.xfnr.2022.12.001
https://doi.org/10.1016/j.xfnr.2022.12.001
Autor:
Rukaia Almshayakhchi, Divya Nagarajan, Jayakumar Vadakekolathu, Barbara-Ann Guinn, Stephen Reeder, Victoria Brentville, Rachael Metheringham, A. Graham Pockley, Lindy Durrant, Stephanie McArdle
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Many cancers, including myeloid leukaemia express the cancer testis antigen (CTA) DDX43 (HAGE) and/or the oncogene Wilms’ tumour (WT1). Here we demonstrate that HAGE/WT1-ImmunoBody® vaccines derived T-cells can kill ex-vivo human CML cell lines ex
Externí odkaz:
https://doaj.org/article/f437f782c2b54899806b100305362a57
Publikováno v:
Carcinogenesis. 43:1015-1029
Epithelial ovarian cancer (EOC) is a prevalent carcinoma in the female population associated with poor prognostic outcomes, in part due to the late stage of the disease at diagnosis. Aiming to identify tumour-associated antigens (TAAs) with the poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75480bc1dd9e2b9188eac75443bb3c97
https://doi.org/10.1093/carcin/bgac084
https://doi.org/10.1093/carcin/bgac084
Autor:
Barbara-ann Guinn, Patrick J. Schuler, Hubert Schrezenmeier, Susanne Hofmann, Johanna Weiss, Christiane Bulach, Marlies Götz, Jochen Greiner
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 11; Pages: 9285
Immune checkpoint inhibitors can block inhibitory molecules on the surface of T cells, switching them from an exhausted to an active state. One of these inhibitory immune checkpoints, programmed cell death protein 1 (PD-1) is expressed on T cell subp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a7df236efbe4b227ef1449c3337bf3
Publikováno v:
Carcinogenesis
Clear cell ovarian cancer (CCOC) is a rare type of epithelial cancer often resistant to platinum-based chemotherapy. Biomarkers for the diagnosis of CCOC, and targets for immunotherapy, both have the potential to improve outcomes for patients. Our re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f28a136de89e08099d1ddee7eb44590
https://doi.org/10.1093/carcin/bgac012
https://doi.org/10.1093/carcin/bgac012