Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Barbara A. Farley"'
Autor:
Victor E. Marquez, Barry M. Goldstein, Barbara A. Farley, Peter T. Rowley, James F. Leary, Paul C. Levy
Publikováno v:
Blood. 78:593-598
Among inducers of myeloid differentiation for leukemic cells, tiazofurin is of special interest because its mechanism of action is known; it inhibits inosine monophosphate dehydrogenase and thus decreases the guanine nucleotide pool. Reported here ar
Publikováno v:
Leukemia research. 16(4)
Agents which induce monocytic characteristics in HL-60 human acute promyelocytic leukemia cells induce mRNA for the fins proto-oncogene, which encodes the receptor for M-CSF. Previous studies of fms expression in HL-60 cells have characterized chiefl
Autor:
Barbara A. Farley
Publikováno v:
Journal of Professional Nursing. 6:311-312
Publikováno v:
Blood. 57:483-490
Neuraminidase treatment of human fetal liver or adult marrow cells prior to culture results in an increased number of erythroid colonies and bursts. No increase occurs in the number of nonerythroid colonies. The number of bursts having more than eigh
Publikováno v:
Blood. 65:862-868
Commitment, ie, the decision to express a differentiated phenotype and to terminate proliferation irreversibly in the absence of inducer, was investigated in K562 human erythroleukemia cells. Cells were cultured for 0, 1, 2, 3, or 4 days with inducer
Autor:
Natalie S. Rudolph, Peter T. Rowley, Barbara A. Farley, Sandra Labella, Barbara A. Kosciolek, Betsy M. Ohlsson-Wilhelm
Publikováno v:
Blood. 59:1098-1102
K562 human erythroleukemia cells are an established cell line derived from an adult with chronic myelogenous leukemia. Hemin stimulates their synthesis of embryonic and fetal hemoglobins. We have found that their globin synthetic pattern depends on t
Publikováno v:
Proceedings of the National Academy of Sciences. 76:1477-1481
A recent theory of the control of human fetal hemoglobin synthesis, based on studies in cultured adult marrow, proposes that the phenotypic expression of fetal hemoglobin is largely dependent on the level of differentiation of the parental stem cells
Publikováno v:
Archives of biochemistry and biophysics. 239(2)
K562 cells are human leukemia cells inducible for hemoglobin synthesis by a variety of agents. This report demonstrates that hypoxanthine, which alone has no inductive effect, enhances induction by thymidine, resulting in a greater absolute, as well
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 75(2)
The liver of the human fetus, induced to abort by prostaglandin or by hypertonic saline, contains cells that form colonies in methylcellulose in vitro. The colonies are erythroid as identified by cellular staining of hemoglobin by benzidine. Colony f
Multipotent human hematopoietic cell line K562: lineage-specific constitutive and inducible antigens
Autor:
Betsy M. Ohlsson-Wilhelm, Sandra Labella, Barbara A. Farley, Peter T. Rowley, Rita Giuliano, James F. Leary
Publikováno v:
Leukemia research. 11(9)
K562 cells have been reported to display a variety of non-erythroid properties. Using 28 lineage-specific monoclonal antibodies, we analysed which antigens are present spontaneously and which are inducible by a variety of agents. The data suggest tha