Výsledky vyhledávání - "Barbara A. Cozens"

From neuronal inclusions to neurodegeneration: neuropathological investigation of a transgenic mouse model of Huntington's disease

Autor: Gillian P. Bates, Amarbirpal Mahal, Laura Mangiarini, Stephen W. Davies, Aysha S. Raza, Mark Turmaine, Barbara A. Cozens

Publikováno v: Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 354(1386)

Huntington'sdisease (HD) is an inherited progressive neurodegenerative disease caused by the expansion of a polyglutamine repeat sequence within a novel protein. Recent work has shown that abnormal intranuclear inclusions of aggregated mutant protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c218656e336d7b191f1fa7838c561a1
https://pubmed.ncbi.nlm.nih.gov/10434295

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Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice

Autor: Colin Hetherington, Alex Harper, Mary J. Seller, Laura Mangiarini, Yvon Trottier, Gillian P. Bates, Martin Lawton, Barbara A. Cozens, Hans Lehrach, Kirupa Sathasivam, Stephen W. Davies

Publikováno v: Cell
Cell, Elsevier, 1996, 87 (3), pp.493-506. ⟨10.1016/s0092-8674(00)81369-0⟩
Cell, 1996, 87 (3), pp.493-506. ⟨10.1016/s0092-8674(00)81369-0⟩

International audience; Huntington's disease (HD) is one of an increasing number of neurodegenerative disorders caused by a CAG/polyglutamine repeat expansion. Mice have been generated that are transgenic for the 5' end of the human HD gene carrying

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf762284ca837bb11b008ca35fc7e99
https://hal.archives-ouvertes.fr/hal-03503775

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Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD Mutation

Autor: Marian DiFiglia, Alan H. Sharp, Stephen W. Davies, Christopher A. Ross, Mark Turmaine, Eberhard Scherzinger, Laura Mangiarini, Erich E. Wanker, Barbara A. Cozens, Gillian P. Bates

Publikováno v: Cell. (3):537-548

Huntington's disease (HD) is one of an increasing number of human neurodegenerative disorders caused by a CAG/polyglutamine-repeat expansion. The mutation occurs in a gene of unknown function that is expressed in a wide range of tissues. The molecula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc6ff6dcf68d52000095630d9a255af

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