Blood-stage Plasmodium vivax antibody dynamics in a low transmission setting: A nine year follow-up study in the Amazon region.

Autor: Camilla V Pires, Jessica R S Alves, Barbara A S Lima, Ruth B Paula, Helena L Costa, Leticia M Torres, Taís N Sousa, Irene S Soares, Bruno A M Sanchez, Cor J F Fontes, Francis B Ntumngia, John H Adams, Flora S Kano, Luzia H Carvalho

Publikováno v: PLoS ONE, Vol 13, Iss 11, p e0207244 (2018)

Plasmodium vivax remains a global health problem and its ability to cause relapses and subpatent infections challenge control and elimination strategies. Even in low malaria transmission settings, such as the Amazon basin, where progress in malaria c

Externí odkaz: https://doaj.org/article/d6f95929b1f64ae3bcf0124c61348167

Multiplexed Microsphere-Based Flow Cytometric Assay to Assess Strain Transcending Antibodies to Plasmodium vivax Duffy Binding Protein II Reveals an Efficient Tool to Identify Binding-Inhibitory Antibody Responders

Autor: John H. Adams, Fernanda Fortes de Araújo, Leticia M. Torres, Luzia H. Carvalho, Francis B. Ntumngia, Jéssica R. S. Alves, Flora S. Kano, Andréa Teixeira-Carvalho, Barbara A. S. Lima, Camilla V. Pires

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Malaria remains a major public health problem worldwide, and Plasmodium vivax is the most widely distributed malaria parasite. Naturally acquired binding inhibitory antibodies (BIAbs) to region II of the Duffy binding protein (DBPII), a P. vivax liga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198b7eacb17bd9b4fba76a44a7592a17
https://www.frontiersin.org/articles/10.3389/fimmu.2021.704653/full

Antibodies to Cryptic Epitopes in Distant Homologues Underpin a Mechanism of Heterologous Immunity between Plasmodium vivax PvDBP and Plasmodium falciparum VAR2CSA

Autor: Sedami Gnidehou, Amanda Maestre, Eliana Arango, Khaled Barakat, Ali Salanti, Francis B. Ntumngia, Stephanie K. Yanow, Luzia H. Carvalho, Flora S. Kano, Michael F. Good, Barbara A. S. Lima, Shanna Banman, Catherine J. Mitran, John H. Adams, Aravindhan Ganesan, Hazel Lugo, Angie Mena, Anthony K. Mbonye

Publikováno v: mBio, Vol 10, Iss 5, p e02343-19 (2019)
mBio, Vol 10, Iss 5 (2019)
Mitran, C J, Mena, A, Gnidehou, S, Banman, S, Arango, E, Lima, B A S, Lugo, H, Ganesan, A, Salanti, A, Mbonye, A K, Ntumngia, F, Barakat, K, Adams, J H, Kano, F S, Carvalho, L H, Maestre, A E, Good, M F & Yanow, S K 2019, ' Antibodies to Cryptic Epitopes in Distant Homologues Underpin a Mechanism of Heterologous Immunity between Plasmodium vivax PvDBP and Plasmodium falciparum VAR2CSA ', mBio, vol. 10, no. 5, e02343-19 . https://doi.org/10.1128/mBio.02343-19

Many pathogens evolve extensive genetic variation in virulence proteins as a strategy to evade host immunity. This poses a significant challenge for the host to develop broadly neutralizing antibodies. In Plasmodium falciparum, we show that a mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce717efb24252a818a7b9357eea13ba
https://doi.org/10.1128/mbio.02343-19

Cross-species immune recognition between Plasmodium vivax Duffy binding protein antibodies and the Plasmodium falciparum surface antigen VAR2CSA

Autor: Jahanara Rajwani, Ali Salanti, Stephanie K. Yanow, Evelyn Medawar, Michael F. Good, Nicaise Tuikue Ndam, Kenneth Gavina, Albert Jin, Francis B. Ntumngia, Flora S. Kano, John H. Adams, Sedami Gnidehou, Amanda Maestre, Luzia H. Carvalho, Patrick E. Duffy, David L. Narum, Eliana Arango, Barbara A. S. Lima, Catherine J. Mitran, Justin Doritchamou, Shanna Banman, Morten Nielsen, Angie Mena

Publikováno v: Repositorio UdeA
Universidad de Antioquia
instacron:Universidad de Antioquia

Background. In pregnancy, Plasmodium falciparum parasites express the surface antigen VAR2CSA, which mediates adherence of red blood cells to chondroitin sulfate A (CSA) in the placenta. VAR2CSA antibodies are generally acquired during infection in p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67f14517ffbbfa1d451221341ab9b6a
http://www.documentation.ird.fr/hor/fdi:010075218

Blood-stage Plasmodium vivax antibody dynamics in a low transmission setting: A nine year follow-up study in the Amazon region

Autor: Taís Nóbrega de Sousa, Camilla V. Pires, Jéssica R. S. Alves, Bruno Antonio Marinho Sanchez, Helena L. Costa, John H. Adams, Leticia M. Torres, Luzia H. Carvalho, Cor Jesus Fernandes Fontes, Francis B. Ntumngia, Flora S. Kano, Irene S. Soares, Barbara A. S. Lima, Ruth B. Paula

Publikováno v: PLoS ONE, Vol 13, Iss 11, p e0207244 (2018)
PLoS ONE
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Plasmodium vivax remains a global health problem and its ability to cause relapses and subpatent infections challenge control and elimination strategies. Even in low malaria transmission settings, such as the Amazon basin, where progress in malaria c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9900831b23ca935ee8512dd14d7962ae
https://doaj.org/article/d6f95929b1f64ae3bcf0124c61348167