Zobrazeno 1 - 10
of 255
pro vyhledávání: '"Barbara A Fox"'
Autor:
Heather L Mercer, Lindsay M Snyder, Claire M Doherty, Barbara A Fox, David J Bzik, Eric Y Denkers
Publikováno v:
PLoS Pathogens, Vol 16, Iss 5, p e1008572 (2020)
The apicomplexan Toxoplasma gondii induces strong protective immunity dependent upon recognition by Toll-like receptors (TLR)11 and 12 operating in conjunction with MyD88 in the murine host. However, TLR11 and 12 proteins are not present in humans, i
Externí odkaz:
https://doaj.org/article/1158ee5894a54cd9af1900b0919a7d3c
Publikováno v:
PLoS Pathogens, Vol 13, Iss 9, p e1006523 (2017)
Externí odkaz:
https://doaj.org/article/aba597dfbd7f4a2eb0528af51a8deac3
Autor:
Abdelbaset E Abdelbaset, Barbara A Fox, Mohamed H Karram, Mahmoud R Abd Ellah, David J Bzik, Makoto Igarashi
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173745 (2017)
In the asexual stages, Toxoplasma gondii stage converts between acute phase rapidly replicating tachyzoites and chronic phase slowly dividing bradyzoites. Correspondingly, T. gondii differentially expresses two distinct genes and isoforms of the lact
Externí odkaz:
https://doaj.org/article/844d4f4c32394da7b33fdc863e109777
Publikováno v:
PLoS Genetics, Vol 12, Iss 7, p e1006189 (2016)
Nonreplicating type I uracil auxotrophic mutants of Toxoplasma gondii possess a potent ability to activate therapeutic immunity to established solid tumors by reversing immune suppression in the tumor microenvironment. Here we engineered targeted del
Externí odkaz:
https://doaj.org/article/b8608f705a304a5a90e03c8867782cdd
Autor:
Leah M Rommereim, Valeria Bellini, Barbara A Fox, Graciane Pètre, Camille Rak, Bastien Touquet, Delphine Aldebert, Jean-François Dubremetz, Marie-France Cesbron-Delauw, Corinne Mercier, David J Bzik
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159306 (2016)
Toxoplasma gondii actively invades host cells and establishes a parasitophorous vacuole (PV) that accumulates many proteins secreted by the dense granules (GRA proteins). To date, at least 23 GRA proteins have been reported, though the function(s) of
Externí odkaz:
https://doaj.org/article/50efb8f011c14294b5231bb87e8c5b4d
Autor:
Thomas Mouveaux, Gabrielle Oria, Elisabeth Werkmeister, Christian Slomianny, Barbara A Fox, David J Bzik, Stanislas Tomavo
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105820 (2014)
Apicomplexan parasites including Toxoplasma gondii have complex life cycles within different hosts and their infectivity relies on their capacity to regulate gene expression. However, little is known about the nuclear factors that regulate gene expre
Externí odkaz:
https://doaj.org/article/b9710e2be60647a7adf0cf190ea6afde
Autor:
Hironori Bando, Yuho Murata, Yongmei Han, Tatsuki Sugi, Yasuhiro Fukuda, David J. Bzik, Barbara A. Fox, Kentaro Kato
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Toxoplasma, an important intracellular parasite of humans and animals, causes life-threatening toxoplasmosis in immunocompromised individuals. Although Toxoplasma secretory proteins during acute infection (tachyzoite, which divides rapidly and causes
Externí odkaz:
https://doaj.org/article/cc9abefb86524b48821386dd5e5ad8e4
Autor:
Tadakimi Tomita, David J Bzik, Yan Fen Ma, Barbara A Fox, Lye Meng Markillie, Ronald C Taylor, Kami Kim, Louis M Weiss
Publikováno v:
PLoS Pathogens, Vol 9, Iss 12, p e1003823 (2013)
Toxoplasma gondii infects up to one third of the world's population. A key to the success of T. gondii as a parasite is its ability to persist for the life of its host as bradyzoites within tissue cysts. The glycosylated cyst wall is the key structur
Externí odkaz:
https://doaj.org/article/95ca94b2043045b19d7810e4b3b92b0e
Autor:
Barbara A Butcher, Barbara A Fox, Leah M Rommereim, Sung Guk Kim, Kirk J Maurer, Felix Yarovinsky, De'Broski R Herbert, David J Bzik, Eric Y Denkers
Publikováno v:
PLoS Pathogens, Vol 7, Iss 9, p e1002236 (2011)
The ROP16 kinase of Toxoplasma gondii is injected into the host cell cytosol where it activates signal transducer and activator of transcription (STAT)-3 and STAT6. Here, we generated a ROP16 deletion mutant on a Type I parasite strain background, as
Externí odkaz:
https://doaj.org/article/5d5a3e6ddba6441b90a69369ee02286d
Autor:
Joseph Lykins, Matthew J. Moschitto, Ying Zhou, Ekaterina V. Filippova, Hoang V. Le, Tadakimi Tomita, Barbara A. Fox, David J. Bzik, Chunlei Su, Seesandra V. Rajagopala, Kristin Flores, Furio Spano, Stuart Woods, Craig W. Roberts, Cong Hua, Kamal El Bissati, Kelsey M. Wheeler, Sarah Dovgin, Stephen P. Muench, Martin McPhillie, Colin W.G. Fishwick, Wayne F. Anderson, Patricia J. Lee, Mark Hickman, Louis M. Weiss, Jitender P. Dubey, Hernan A. Lorenzi, Richard B. Silverman, Rima L. McLeod
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108477- (2024)
Summary: Toxoplasma gondii causes morbidity, mortality, and disseminates widely via cat sexual stages. Here, we find T. gondii ornithine aminotransferase (OAT) is conserved across phyla. We solve TgO/GABA-AT structures with bound inactivators at 1.55
Externí odkaz:
https://doaj.org/article/4214ce2e3d344bdb89d711a4b2786ce4