Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Barbara A, Conley"'
Autor:
Oluwadamilola Olaku, Barbara A. Conley, S. Percy Ivy, Lisa M. McShane, Louis M. Staudt, Sophie M. King, Megan Sansevere, Benjamin Kim, Jeffrey D. White
Publikováno v:
Translational Oncology, Vol 25, Iss , Pp 101484- (2022)
Introduction: The Exceptional Responders Initiative (ERI) at the National Cancer Institute attempts to correlate unusually good outcomes in patients with cancer with genetic targets in tumors and the therapies the patients received. It is not known i
Externí odkaz:
https://doaj.org/article/88a2f3c40f2742269a89ec944cd51d28
Autor:
Amy S. Clark, Fangxin Hong, Richard S. Finn, Angela M. DeMichele, Edith P. Mitchell, James Zwiebel, Fernanda I. Arnaldez, Robert J. Gray, Victoria Wang, Lisa M. McShane, Larry V. Rubinstein, David Patton, P. Mickey Williams, Stanley R. Hamilton, Mehmet S. Copur, Samer S. Kasbari, Ravneet Thind, Barbara A. Conley, Carlos L. Arteaga, Peter J. O'Dwyer, Lyndsay N. Harris, Alice P. Chen, Keith T. Flaherty
Publikováno v:
Clinical Cancer Research. 29:1477-1483
Purpose: Cyclin D/CDK4/6 is critical in controlling the G1 to S checkpoint. CCND, the gene encoding cyclin D, is known to be amplified in a variety of solid tumors. Palbociclib is an oral CDK4/6 inhibitor, approved in advanced breast cancer in combin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0deaba3a14fb4dcac6730d29e90dbb46
https://doi.org/10.1158/1078-0432.ccr-22-2150
https://doi.org/10.1158/1078-0432.ccr-22-2150
Autor:
Philippe L. Bedard, Shuli Li, Kari B. Wisinski, Eddy S. Yang, Sewanti A. Limaye, Edith P. Mitchell, James A. Zwiebel, Jeffrey A. Moscow, Robert J. Gray, Victoria Wang, Lisa M. McShane, Larry V. Rubinstein, David R. Patton, P. Mickey Williams, Stanley R. Hamilton, Barbara A. Conley, Carlos L. Arteaga, Lyndsay N. Harris, Peter J. O'Dwyer, Alice P. Chen, Keith T. Flaherty
Publikováno v:
JCO precision oncology. 6
PURPOSE National Cancer Institute–Molecular Analysis for Therapy Choice is a multicohort trial that assigns patients with advanced cancers to targeted therapies on the basis of central tumor genomic testing. Arm B evaluated afatinib, an ErbB family
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6bf59fabbdedba6f33eccff12578795
https://pubmed.ncbi.nlm.nih.gov/35939768
https://pubmed.ncbi.nlm.nih.gov/35939768
Autor:
Senthil, Damodaran, Fengmin, Zhao, Dustin A, Deming, Edith P, Mitchell, John J, Wright, Robert J, Gray, Victoria, Wang, Lisa M, McShane, Larry V, Rubinstein, David R, Patton, P Mickey, Williams, Stanley R, Hamilton, Jennifer M, Suga, Barbara A, Conley, Carlos L, Arteaga, Lyndsay N, Harris, Peter J, O'Dwyer, Alice P, Chen, Keith T, Flaherty
Publikováno v:
J Clin Oncol
Activating mutations in PIK3CA are observed across multiple tumor types. The NCI-MATCH (EAY131) is a tumor-agnostic platform trial that enrolls patients to targeted therapies on the basis of matching genomic alterations. Arm Z1F evaluated copanlisib,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cfbcd9071baf869343e1deaeda8697f7
https://pubmed.ncbi.nlm.nih.gov/35133871
https://pubmed.ncbi.nlm.nih.gov/35133871
Autor:
Keith T. Flaherty, Alice P. Chen, Lyndsay N. Harris, Peter J. O'Dwyer, Carlos L. Arteaga, Barbara A. Conley, Ravneet Thind, Samer S. Kasbari, Mehmet S. Copur, Stanley R. Hamilton, P. Mickey Williams, David Patton, Larry V. Rubinstein, Lisa M. McShane, Victoria Wang, Robert J. Gray, Fernanda I. Arnaldez, James Zwiebel, Edith P. Mitchell, Angela M. DeMichele, Richard S. Finn, Fangxin Hong, Amy S. Clark
Representativeness of Study Participants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e238d00836438710bd3e04e5688eb2
https://doi.org/10.1158/1078-0432.22633064.v1
https://doi.org/10.1158/1078-0432.22633064.v1
Autor:
Keith T. Flaherty, Alice P. Chen, Lyndsay N. Harris, Peter J. O'Dwyer, Carlos L. Arteaga, Barbara A. Conley, Ravneet Thind, Samer S. Kasbari, Mehmet S. Copur, Stanley R. Hamilton, P. Mickey Williams, David Patton, Larry V. Rubinstein, Lisa M. McShane, Victoria Wang, Robert J. Gray, Fernanda I. Arnaldez, James Zwiebel, Edith P. Mitchell, Angela M. DeMichele, Richard S. Finn, Fangxin Hong, Amy S. Clark
Purpose:Cyclin D/CDK4/6 is critical in controlling the G1 to S checkpoint. CCND, the gene encoding cyclin D, is known to be amplified in a variety of solid tumors. Palbociclib is an oral CDK4/6 inhibitor, approved in advanced breast cancer in combina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2562eea6433e82a479a4864ae9520a
https://doi.org/10.1158/1078-0432.c.6533050.v1
https://doi.org/10.1158/1078-0432.c.6533050.v1
Autor:
Kari B. Wisinski, Yael Flamand, Melissa A. Wilson, Jason J. Luke, Hussein A. Tawbi, Fangxin Hong, Edith P. Mitchell, James A. Zwiebel, Helen Chen, Robert J. Gray, Shuli Li, Lisa M. McShane, Lawrence V. Rubinstein, David Patton, P. Mickey Williams, Stanley R. Hamilton, Robert J. Behrens, Kathryn P. Pennington, Barbara A. Conley, Carlos L. Arteaga, Lyndsay N. Harris, Peter J. O'Dwyer, Alice P. Chen, Keith T. Flaherty
Publikováno v:
JCO Precision Oncology.
PURPOSE NCI-MATCH is a precision medicine trial using genomic testing to allocate patients with advanced malignancies to targeted treatment subprotocols. This report combines two subprotocols evaluating trametinib, a MEK1/2 inhibitor, in patients wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71e7974ca3a3bd63e99d10e121ed73af
https://doi.org/10.1200/po.22.00421
https://doi.org/10.1200/po.22.00421
Autor:
Keith T. Flaherty, Alice P. Chen, Peter J. O'Dwyer, Lyndsay N. Harris, Carlos L. Arteaga, Barbara A. Conley, Stanly R. Hamilton, P. Mickey Williams, David Patton, Larry V. Rubinstein, Lisa M. McShane, Shuli Li, Robert J. Gray, Helen X. Chen, John J. Wright, Edith P. Mitchell, Gregory J. Riely, Marcus Noel, Fengmin Zhao, Douglas B. Johnson
Supplementary Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062bb0c8d61e0546bf2732428d41259a
https://doi.org/10.1158/1078-0432.22479149.v1
https://doi.org/10.1158/1078-0432.22479149.v1
Autor:
James H. Doroshow, Richard M. Simon, Barbara A. Conley, Robert J. Kinders, P. Mickey Williams, Seth M. Steinberg, Paul M. McGregor, William D. Walsh, Michele G. Mehaffey, Chih-Jian Lih, Deborah E. Allen, Jiuping Ji, Alice P. Chen, Ahrim Youn, Peter M. Szabo, Robert J. Morgan, Miguel A. Villalona-Calero, Michael J. Naughton, David R. Gandara, Daniel M. Sullivan, Gini F. Fleming, Amit M. Oza, Shivaani Kummar
Supplemental Figure S1. Kaplan-Meier analysis of the progression free survival (PFS) of patients on each treatment arm stratified by BRCA status showed no significant differences.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac78b660c4e98ad73ca9863a9f1c1ebb
https://doi.org/10.1158/1078-0432.22461263.v1
https://doi.org/10.1158/1078-0432.22461263.v1
Autor:
Keith T. Flaherty, Alice P. Chen, Carlos L. Arteaga, Lyndsay N. Harris, Peter J. O'Dwyer, Andrew J. Aguirre, Barbara A. Conley, Stanley R. Hamilton, P. Mickey Williams, Melissa S. Dillmon, Funda Meric-Bernstam, David R. Patton, Larry V. Rubinstein, Lisa M. McShane, Robert J. Gray, Shuli Li, Helen X. Chen, Kevin S. Kapner, James A. Zwiebel, Edith P. Mitchell, E. Scott Kopetz, Rebecca S. Heist, Victoria Wang, James M. Cleary
Supplemental Table
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf259f6c19129fabcf67f0792ad4b427
https://doi.org/10.1158/1078-0432.22478994.v1
https://doi.org/10.1158/1078-0432.22478994.v1