Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Barbara A, Bricker"'
Autor:
Chandrashekar Voshavar, Uma Maheshwar Gonela, Seth Y. Ablordeppey, Suresh Eyunni, Edward Ofori, Edem K. Onyameh, Hye Jin Kang, Barbara A. Bricker
Publikováno v:
Med Chem Res
Compound 1c, 2-(2-(3,4-Dihydroisoquinolin-2(1H)-yl)ethyl)-5-fluoro-2,3-dihydro-1H-inden-1-one was previously reported from our laboratory showing high affinity binding to the 5-HT7 receptor (Ki = 0.5 nM). However, compound 1c racemizes readily upon e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9e95be8670ea45d3f6c43006bfc69f
https://europepmc.org/articles/PMC8942385/
https://europepmc.org/articles/PMC8942385/
Autor:
Gladys Asong, Terrick Andey, Felix Amissah, Barbara A. Bricker, Xue Y. Zhu, Seth Y. Ablordeppey, Nazarius S. Lamango
Publikováno v:
Bioorg Med Chem
Our previous study has revealed 4-(4-(4-chlorophenyl)-1,4-diazepan-1-yl)-1-(4-fluorophenyl)butan-1-one·2HCl (SYA013) 1 as a sigma ligand with moderate selectivity for the sigma-2 receptor. Given the overexpression of sigma receptors in solid tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b92f52f1276b37ee25030be5ecfa32d8
https://doi.org/10.1016/j.bmc.2019.04.012
https://doi.org/10.1016/j.bmc.2019.04.012
Publikováno v:
Biomedical Chromatography. 33
In previous structure-activity relationship studies to identify new and selective 5-HT7 receptor (5-HT7 R) ligands, we identified the chiral compound, 5-chloro-2-{2-[3,4-dihydroisoquinoline-2(1H)-yl]ethyl}-2-methyl-2,3-dihydro-1H-inden-1-one (SYA 402
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1f0af153539a7e5e8c3e10008fd805d
https://doi.org/10.1002/bmc.4565
https://doi.org/10.1002/bmc.4565
Publikováno v:
Biomed Chromatogr
In a previous structure activity relationship studies to identify new and selective 5-HT(7) receptor (5-HT(7)R) ligands, we have identified the chiral compound, 5-chloro-2-(2-(3,4-dihydroisoquinoline-2(1H)-yl)ethyl)-2-methyl-2,3-dihydro-1H-inden-1-on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dabb04a4097dd68768861eecaacadf69
https://pubmed.ncbi.nlm.nih.gov/31032988
https://pubmed.ncbi.nlm.nih.gov/31032988
SYA16263 exhibited moderate radioligand binding affinity at the D2 receptor and produced inhibition of apomorphine-induced climbing behavior in mice with an ED50 value of 3.88 mg/kg IP, predicting potential antipsychotic effects in humans. Analysis o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb923ade78ff63718ce24bb37965361
https://europepmc.org/articles/PMC6581196/
https://europepmc.org/articles/PMC6581196/
Autor:
Barbara A. Bricker, Uma Maheshwar Gonela, Edward Ofori, Jennifer L. Schmachtenberg, Aaron Janowsky, Tracy L. Swanson, Seth Y. Ablordeppey, Shelley H. Bloom, Amy J. Eshleman, Edem K. Onyameh, Chandrashekhar Voshavar
Publikováno v:
Eur J Med Chem
We have previously reported that dual 5-HT(1A) and 5-HT(7) receptor ligands might find utility as treatment options for various CNS related conditions including cognitive and anxiolytic impairments. We have also more recently reported that SYA16263 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13cd4d2d79ea29cac08311213228c0e3
https://doi.org/10.1016/j.ejmech.2021.113243
https://doi.org/10.1016/j.ejmech.2021.113243
Autor:
Barbara A. Bricker, Seth Y. Ablordeppey, Uma Maheshwar Gonela, Edem K. Onyameh, Chandrashekhar Voshavar, Suresh Eyunni, Edward Ofori, Andrea Jenkins
Publikováno v:
Bioorg Med Chem
Dopamine (DA) and serotonin (5-HT) receptors are prime targets for the development of antipsychotics. The specific role of each receptor subtype to the pharmacological effects of antipsychotic drugs remains unclear. Understanding the relationship bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89f2c7395f3d274f85e2d40653f6d4be
https://doi.org/10.1016/j.bmc.2020.115943
https://doi.org/10.1016/j.bmc.2020.115943
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:5730-5740
Diseases of the CNS are often complex and involve multiple receptor systems and thus, the treatment options for these diseases must focus on targeting the multiple receptors implicated in the various disorders. Schizophrenia and depression are exampl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6aace01084defef0d91e64b1b1fb265
https://doi.org/10.1016/j.bmc.2016.09.019
https://doi.org/10.1016/j.bmc.2016.09.019
Autor:
Barbara A. Bricker, Edem K. Onyameh, Hye Jin Kang, Jagan R. Etukala, Xue Y. Zhu, Suresh Eyunni, Xi Ping Huang, Bryan L. Roth, Edward Ofori, Seth Y. Ablordeppey
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:3671-3679
Several known D2 pharmacophores have been explored as templates for identifying ligands with multiple binding affinities at dopamine and serotonin receptors considered as clinically relevant receptors in the treatment of neuropsychiatric diseases. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e79bcd639d59eb30bb9052da0a497ea
https://doi.org/10.1016/j.bmc.2016.06.011
https://doi.org/10.1016/j.bmc.2016.06.011
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 16:555-578
Pathogenic fungi are a major causative group for opportunistic infections (OIs). AIDS patients and other immunocompromised individuals are at risk for OIs, which if not treated appropriately, contribute to the mortality associated with their conditio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69d563d9c0a7c19197afa9ac950d48b7
https://doi.org/10.2174/1389557516666160118112103
https://doi.org/10.2174/1389557516666160118112103