Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Barbara‐ann Guinn"'
Publikováno v:
Onco, Vol 4, Iss 2, Pp 87-100 (2024)
Lung cancer (LC) is one of the leading causes of cancer-related deaths. Pulmonary nodules are one of the risk factors, and their discovery rate has been increasing due to enhanced performance of chest CT scans, but more than 90% are non-malignant, ca
Externí odkaz:
https://doaj.org/article/1aa2966e2fc24c338e9d89c53478eaf6
Autor:
Jeanette M. Rotchell, Chloe Austin, Emma Chapman, Charlotte A. Atherall, Catriona R. Liddle, Timothy S. Dunstan, Ben Blackburn, Andrew Mead, Kate Filart, Ellie Beeby, Keith Cunningham, Jane Allen, Hannah Draper, Barbara-ann Guinn
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 274, Iss , Pp 116208- (2024)
Microplastics (MPs) are found in all environments, within the human food chain, and have been recently detected in several human tissues. The objective herein was to undertake an analysis of MP contamination in human urine samples, from healthy indiv
Externí odkaz:
https://doaj.org/article/32254a11143e47fe9be2670ef9e408ac
Publikováno v:
eJHaem, Vol 3, Iss 3, Pp 596-608 (2022)
Abstract Recent studies have shown that short non‐coding RNAs, known as microRNAs (miRNAs) and their dysregulation, are implicated in the pathogenesis of acute myeloid leukaemia (AML). This is due to their role in the control of gene expression in
Externí odkaz:
https://doaj.org/article/d4adf5da03644ac7909d6a3690bca915
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9667 (2023)
Acute myeloid leukaemia (AML) is characterized by impaired myeloid differentiation resulting in an accumulation of immature blasts in the bone marrow and peripheral blood. Although AML can occur at any age, the incidence peaks at age 65. The pathobio
Externí odkaz:
https://doaj.org/article/654157fa127f4c4d8136df91379fb0a7
Autor:
Barbara-ann Guinn, Patrick J. Schuler, Hubert Schrezenmeier, Susanne Hofmann, Johanna Weiss, Christiane Bulach, Marlies Götz, Jochen Greiner
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9285 (2023)
Immune checkpoint inhibitors can block inhibitory molecules on the surface of T cells, switching them from an exhausted to an active state. One of these inhibitory immune checkpoints, programmed cell death protein 1 (PD-1) is expressed on T cell subp
Externí odkaz:
https://doaj.org/article/68f05d842e334c0fb2f9bc4f2769c710
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Endogenous metals are required for all life, orchestrating the action of diverse cellular processes that are crucial for tissue function. The dynamic wound healing response is underpinned by a plethora of such cellular behaviours, occurring in a time
Externí odkaz:
https://doaj.org/article/3e1ec66e61da4aec9b2c5202d7465c82
Autor:
Rukaia Almshayakhchi, Divya Nagarajan, Jayakumar Vadakekolathu, Barbara-Ann Guinn, Stephen Reeder, Victoria Brentville, Rachael Metheringham, A. Graham Pockley, Lindy Durrant, Stephanie McArdle
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Many cancers, including myeloid leukaemia express the cancer testis antigen (CTA) DDX43 (HAGE) and/or the oncogene Wilms’ tumour (WT1). Here we demonstrate that HAGE/WT1-ImmunoBody® vaccines derived T-cells can kill ex-vivo human CML cell lines ex
Externí odkaz:
https://doaj.org/article/f437f782c2b54899806b100305362a57
Autor:
Viktoriya B. Boncheva, Michael Linnebacher, Said Kdimati, Hannah Draper, Laurence Orchard, Ken I. Mills, Gerald O’Sullivan, Mark Tangney, Barbara-ann Guinn
Publikováno v:
Biomolecules, Vol 12, Iss 8, p 1058 (2022)
A Crohn’s-like lymphoid reaction (CLR) is observed in about 15% of colorectal cancer (CRC) patients and is associated with favourable outcomes. To identify the immune targets recognised by CRC CLR patient sera, we immunoscreened a testes cDNA libra
Externí odkaz:
https://doaj.org/article/c364a480018545e4a16d08b5ea91e6f6
Autor:
Elliott Brown, Barbara-ann Guinn
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 11, p 6251 (2022)
Acute myeloid leukaemia (AML) is defined as a malignant disorder of the bone marrow (BM) that is characterised by the clonal expansion and differentiation arrest of myeloid progenitor cells [...]
Externí odkaz:
https://doaj.org/article/d62e49f580a84e3da8164dd660a2c38c
Autor:
Jochen Greiner, Elliott Brown, Lars Bullinger, Robert K. Hills, Vanessa Morris, Hartmut Döhner, Ken I. Mills, Barbara-ann Guinn
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10482 (2021)
Despite recent advances in therapies including immunotherapy, patients with acute myeloid leukaemia (AML) still experience relatively poor survival rates. The Inhibition of Apoptosis (IAP) family member, survivin, also known by its gene and protein n
Externí odkaz:
https://doaj.org/article/b458887357264f16a83fb7784b890a7f