Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Barbara, Tong"'
Autor:
Elliott, Vichinsky, Carolyn C, Hoppe, Kenneth I, Ataga, Russell E, Ware, Videlis, Nduba, Amal, El-Beshlawy, Hoda, Hassab, Maureen M, Achebe, Salam, Alkindi, R Clark, Brown, David L, Diuguid, Paul, Telfer, Dimitris A, Tsitsikas, Ashraf, Elghandour, Victor R, Gordeuk, Julie, Kanter, Miguel R, Abboud, Joshua, Lehrer-Graiwer, Margaret, Tonda, Allison, Intondi, Barbara, Tong, Jo, Howard, Julie, Kanter Washko
Publikováno v:
The New England journal of medicine. 381(6)
Deoxygenated sickle hemoglobin (HbS) polymerization drives the pathophysiology of sickle cell disease. Therefore, direct inhibition of HbS polymerization has potential to favorably modify disease outcomes. Voxelotor is an HbS polymerization inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b73bdd279bf022b9774c5beb0fb85ce
https://pubmed.ncbi.nlm.nih.gov/31199089
https://pubmed.ncbi.nlm.nih.gov/31199089
Publikováno v:
Contemporary Clinical Trials. 98:106161
Sickle cell disease (SCD) is an inherited disease characterized by hemolysis, anemia, and vaso-occlusion leading to substantial morbidity and mortality. Development of prior pharmacologic therapies exclusively utilized vaso-occlusive crisis (VOC) as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a77f6fdf29c8e758af9e8858a371ab
https://doi.org/10.1016/j.cct.2020.106161
https://doi.org/10.1016/j.cct.2020.106161
Autor:
Margaret Tonda, Joshua Lehrer-Graiwer, Adlette Inati, Irene Agodoa, Kenneth I. Ataga, Elliott Vichinsky, Paul Telfer, Barbara Tong
Publikováno v:
Blood. 134:2313-2313
Background: Sickle cell disease (SCD) is an inherited disorder in which pathology is driven by hemoglobin (Hb) polymerization and red blood cell sickling, leading to chronic anemia and hemolysis as well as episodic vaso-occlusive crises (VOC). These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbe8a3fe91c155c0f47fee4016102dad
https://doi.org/10.1182/blood-2019-129026
https://doi.org/10.1182/blood-2019-129026
Autor:
Joshua Lehrer-Graiwer, Barbara Tong, Miguel R. Abboud, Russell E. Ware, Carolyn Hoppe, Clark Brown, Mariane de Montalembert, Margaret Tonda
Publikováno v:
Blood. 134:1003-1003
Background: Sickle cell disease (SCD) is a chronic, debilitating disorder caused by a mutation in beta globin, which leads to the production of sickle hemoglobin (HbS). Deoxygenated HbS polymerization results in red blood cell (RBC) sickling, which l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7389dca3542f6a5f7cb1482dae090048
https://doi.org/10.1182/blood-2019-130767
https://doi.org/10.1182/blood-2019-130767
Autor:
Margaret Tonda, Jennifer Knight-Madden, Barbara Tong, Joshua Lehrer-Graiwer, Jo Howard, Elliott Vichinsky, Victor R. Gordeuk, Carla Washington
Publikováno v:
Blood. 134:1020-1020
Background: Sickle cell disease (SCD) is an inherited disorder in which pathology is driven by hemoglobin (Hb) polymerization and red blood cell sickling, leading to chronic hemolysis and anemia as well as episodic vaso-occlusion. These manifestation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfb23b8d2995c1671d0fe19798a5571c
https://doi.org/10.1182/blood-2019-130802
https://doi.org/10.1182/blood-2019-130802
Autor:
Joo Hee Yi, Ian E. Krop, Howard A. Burris, Bei Wang, Dan Lu, Manish Gupta, S. N. Holden, Sandhya Girish, Barbara Tong, Yu Waye Chu, Patricia LoRusso, Amita Joshi, Charles L. Vogel, Ola Saad
Publikováno v:
Cancer Chemotherapy and Pharmacology
Purpose Trastuzumab emtansine (T-DM1) is an antibody–drug conjugate comprising trastuzumab and DM1, a microtubule polymerization inhibitor, covalently bound via a stable thioether linker. To characterize the pharmacokinetics (PK) of T-DM1 in patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2631b69ccf7a3793d0af35db0680906
http://europepmc.org/articles/PMC3337408
http://europepmc.org/articles/PMC3337408
Autor:
Sandra Milan, Jon P. Gockerman, Kimberly Denis-Mize, Maurice J. Wolin, Alan Yuen, Alexandra Levine, William Larry Gluck, Susan E. Wilson, Mark A. Dayton, Barbara Tong, Dawn Navis, Jennifer Lucas, Deborah Hurst, Anita Difrancesco
Publikováno v:
Clinical Cancer Research. 10:2253-2264
Purpose: Expansion and activation of natural killer (NK) cells with interleukin-2 (IL-2) may enhance antibody-dependent cellular cytotoxicity (ADCC), an important mechanism of rituximab activity. Two parallel Phase I studies evaluated combination the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4d345928d74f1162689730d391ea4e8
https://doi.org/10.1158/1078-0432.ccr-1087-3
https://doi.org/10.1158/1078-0432.ccr-1087-3
Autor:
Kert Viele, Barbara Tong
Publikováno v:
Statistics and Computing. 12:315-330
Consider data (x1,y1),…,(xn,yn), where each xi may be vector valued, and the distribution of yi given xi is a mixture of linear regressions. This provides a generalization of mixture models which do not include covariates in the mixture formulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03c75f6a2264e6d2d819978ab9177668
https://doi.org/10.1023/a:1020779827503
https://doi.org/10.1023/a:1020779827503
Autor:
Barbara Tong, Kert Viele
Publikováno v:
Canadian Journal of Statistics. 28:551-562
Posterior distributions for mixture models often have multiple modes, particularly near the boundaries of the parameter space where the component variances are small. This multimodality results in predictive densities that are extremely rough. The au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34da422959767a606166d04e7f3f068a
https://doi.org/10.2307/3315964
https://doi.org/10.2307/3315964
Autor:
Luc Dirix, Janice Lu, Edith A. Perez, Yu Waye Chu, Vivian Ng, Chunyan Song, Ellie Guardino, Barbara Tong, Giulia Bianchi, Judit Kocsis, Jeferson Vinholes, Sara A. Hurvitz
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 31(9)
Purpose Trastuzumab emtansine (T-DM1), an antibody-drug conjugate composed of the cytotoxic agent DM1 conjugated to trastuzumab via a stable thioether linker, has shown clinical activity in single-arm studies enrolling patients with human epidermal g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2cb237e4a2f6f58575080fec4854364
https://pubmed.ncbi.nlm.nih.gov/23837759
https://pubmed.ncbi.nlm.nih.gov/23837759