Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Barbara, Potempa"'
Autor:
Tomas Weitoft, Johan Rönnelid, Anders Lind, Charlotte de Vries, Anders Larsson, Barbara Potempa, Jan Potempa, Alf Kastbom, Klara Martinsson, Karin Lundberg, Marieann Högman
Publikováno v:
Biomedicines, Vol 12, Iss 5, p 964 (2024)
Patients with rheumatoid arthritis (RA) have altered levels of exhaled nitric oxide (NO) compared with healthy controls. Here, we investigated whether the clinical features of and immunological factors in RA pathogenesis could be linked to the NO lun
Externí odkaz:
https://doaj.org/article/9eaad13277ad4a86bb2915a57d3fe483
Autor:
Anna Svärd, Alf Kastbom, Karin Roos Ljungberg, Barbara Potempa, Jan Potempa, G. Rutger Persson, Stefan Renvert, Johan Sanmartin Berglund, Maria K. Söderlin
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundPeriodontitis and oral pathogenic bacteria can contribute to the development of rheumatoid arthritis (RA). A connection between serum antibodies to Porphyromonas gingivalis (P. gingivalis) and RA has been established, but data on saliva ant
Externí odkaz:
https://doaj.org/article/d1309176e27f405f9ae09df85f9fbbb3
Autor:
Izabela Ciaston, Joanna Budziaszek, Dorota Satala, Barbara Potempa, Andrew Fuchs, Maria Rapala-Kozik, Danuta Mizgalska, Ewelina Dobosz, Richard J. Lamont, Jan Potempa, Joanna Koziel
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Porphyromonas gingivalis, a keystone pathogen in periodontitis (PD), produces cysteine proteases named gingipains (RgpA, RgpB, and Kgp), which strongly affect the host immune system. The range of action of gingipains is extended by their rel
Externí odkaz:
https://doaj.org/article/6f6b4ca4d2f04f4ca85c9ff93ed741ac
Autor:
Anna Gasiorek, Ewelina Dobosz, Barbara Potempa, Izabela Ciaston, Mateusz Wilamowski, Zuzanna Oruba, Richard J. Lamont, Jolanta Jura, Jan Potempa, Joanna Koziel
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
Periodontitis is a highly prevalent disease caused by accumulation of a bacterial biofilm. Periodontal pathogens use a number of virulence strategies that are under intensive study to find optimal therapeutic approaches against bone loss.
Externí odkaz:
https://doaj.org/article/af4c8cd5bca9406eb3e0f870b22e0bd5
Autor:
Katarina Hočevar, Matej Vizovišek, Alicia Wong, Joanna Kozieł, Marko Fonović, Barbara Potempa, Richard J. Lamont, Jan Potempa, Boris Turk
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Porphyromonas gingivalis, the main etiologic agent of periodontitis, secretes cysteine proteases named gingipains. HRgpA and RgpB gingipains have Arg-specificity, while Kgp gingipain is Lys-specific. Together they can cleave an array of proteins and
Externí odkaz:
https://doaj.org/article/b5f84353b5654e30925e7e9b2cbb8b13
Autor:
Rielana Wichert, Anna Ermund, Stefanie Schmidt, Matthias Schweinlin, Miroslaw Ksiazek, Philipp Arnold, Katharina Knittler, Frederike Wilkens, Barbara Potempa, Björn Rabe, Marit Stirnberg, Ralph Lucius, Jörg W. Bartsch, Susanna Nikolaus, Maren Falk-Paulsen, Philip Rosenstiel, Marco Metzger, Stefan Rose-John, Jan Potempa, Gunnar C. Hansson, Peter J. Dempsey, Christoph Becker-Pauly
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2090-2103 (2017)
The host metalloprotease meprin β is required for mucin 2 (MUC2) cleavage, which drives intestinal mucus detachment and prevents bacterial overgrowth. To gain access to the cleavage site in MUC2, meprin β must be proteolytically shed from epithelia
Externí odkaz:
https://doaj.org/article/b24e999113e241ad82f86e3fbecdd8d3
Autor:
Danuta Bryzek, Izabela Ciaston, Ewelina Dobosz, Anna Gasiorek, Anna Makarska, Michal Sarna, Sigrun Eick, Magdalena Puklo, Maciej Lech, Barbara Potempa, Jan Potempa, Joanna Koziel
Publikováno v:
PLoS Pathogens, Vol 15, Iss 5, p e1007773 (2019)
Neutrophil-derived networks of DNA-composed extracellular fibers covered with antimicrobial molecules, referred to as neutrophil extracellular traps (NETs), are recognized as a physiological microbicidal mechanism of innate immunity. The formation of
Externí odkaz:
https://doaj.org/article/2ec1968dc25b43009beb253950884207
Autor:
Justyna Karkowska-Kuleta, Magdalena Surowiec, Mariusz Gogol, Joanna Koziel, Barbara Potempa, Jan Potempa, Andrzej Kozik, Maria Rapala-Kozik
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2495 (2020)
Microorganisms that create mixed-species biofilms in the human oral cavity include, among others, the opportunistic fungus Candida albicans and the key bacterial pathogen in periodontitis, Porphyromonas gingivalis. Both species use arsenals of virule
Externí odkaz:
https://doaj.org/article/e0ff0acdca3d4d8ea2510ddbb852a80d
Autor:
Jan Potempa, Joanna Koziel, Izabela Glowczyk, Alicia Wong, Barbara Potempa, Olena Babyak, Maciej Lech, Richard J. Lamont
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
Gingipain cysteine proteases are considered key virulence factors of Porphyromonas gingivalis. They significantly influence antibacterial and homeostatic functions of macrophages, neutrophils, the complement system, and cytokine networks. Recent data
Externí odkaz:
https://doaj.org/article/d304316f0404458f8bda5fd0b164fdf5
Autor:
Jan Potempa, Tomas Koudelka, Christoph Becker-Pauly, Jeanette Schwarz, Stefan Rose-John, Irit Sagi, Jörg W. Bartsch, Andreas Tholey, Rielana Wichert, Paul Saftig, Sebastian Wetzel, Franka Scharfenberg, Barbara Potempa, Cynthia Colmorgen
Publikováno v:
FASEB J
Meprin β is a membrane-bound metalloprotease involved in extracellular matrix assembly and inflammatory processes in health and disease. A disintegrin and metalloproteinase (ADAM)10 and ADAM17 are physiologic relevant sheddases of inactive promeprin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d4810fe36b39e5d5acca2b505f02ce
https://doi.org/10.1096/fj.201801371r
https://doi.org/10.1096/fj.201801371r