Inhalable nano into micro dry powders for ivacaftor delivery: The role of mannitol and cysteamine as mucus-active agents

Autor: Gaetano Giammona, Gennara Cavallaro, Laura Lentini, Aldo Di Leonardo, Barbara Porsio, Fabiana Quaglia, Francesca Ungaro

Publikováno v: International journal of pharmaceutics. 582

In this paper the innovative approach of Nano into micro (NiM9 was developed to produce Nanoparticles loaded Ivacaftor to incorporate into mannitol or mannitol/cysteamine micromatrices for drug pulmonary administration in CF. Nanoparticles composed b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b457a034b607183e4902f1077aec206d
https://pubmed.ncbi.nlm.nih.gov/32272167

Polyanion–tobramycin nanocomplexes into functional microparticles for the treatment of Pseudomonas aeruginosa infections in cystic fibrosis

Autor: Dario Spigolon, Domenico Schillaci, Gennara Cavallaro, Maria Grazia Cusimano, Emanuela Fabiola Craparo, Gaetano Giammona, Barbara Porsio

Publikováno v: Nanomedicine. 12:25-42

Aim: Efficacy of antibiotics in cystic fibrosis (CF) is compromised by the poor penetration through mucus barrier. This work proposes a new ‘nano-into-micro’ approach, used to obtain a combinatorial effect: achieve a sustained delivery of tobramy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37302db22e7363827d32eef457942980
https://doi.org/10.2217/nnm-2016-0262

Nanometric ion pair complexes of tobramycin forming microparticles for the treatment of Pseudomonas aeruginosa infections in cystic fibrosis

Autor: Roberto Santucci, Davide De Rocco, Gennara Cavallaro, Gaetano Giammona, Enea Gino Di Domenico, Fiorentina Ascenzioni, Carla Sardo, Barbara Porsio

Sustained pulmonary delivery of tobramycin from microparticles composed of drug/polymer nanocomplexes offers several advantages against traditional delivery methods. Namely, in patients with cystic fibrosis, microparticle delivery can protect the tob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44912a3daea30a8dace8448eb4d1567
http://hdl.handle.net/11573/1278596

Evaluation of biodegradability on polyaspartamide-polylactic acid based nanoparticles by chemical hydrolysis studies

Autor: Emanuela Fabiola Craparo, Gaetano Giammona, Barbara Porsio, Gennara Cavallaro, Maria Luisa Bondì

Publikováno v: Polymer degradation and stability 119 (2015): 56–67. doi:10.1016/j.polymdegradstab.2015.05.003
info:cnr-pdr/source/autori:Craparo Emanuela Fabiola1 Porsio Barbara1 Bondì Maria Luisa2 Giammona Gaetano1 Cavallaro Gennara1/titolo:Evaluation of biodegradability on polyspartamide-polylactic acid based nano particles by chemical hydrolysis studies/doi:10.1016%2Fj.polymdegradstab.2015.05.003/rivista:Polymer degradation and stability/anno:2015/pagina_da:56/pagina_a:67/intervallo_pagine:56–67/volume:119

Here, the synthesis of two graft copolymers based on ?,?-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA) and poly(lactic acid) (PLA), the O-(2-aminoethyl)-O'-galactosyl polyethylene glycol (GAL-PEG-NH2) or the methoxypolyethylene glycol amine (H2N-PEG-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba42da13a757ec4c2fd768d1c12e5e3
https://doi.org/10.1016/j.polymdegradstab.2015.05.003

Nano into Micro Formulations of Tobramycin for the Treatment of Pseudomonas aeruginosa Infections in Cystic Fibrosis

Autor: Barbara Porsio, Gennara Cavallaro, Emanuela Fabiola Craparo, Gaetano Giammona, Domenico Schillaci, Maria Grazia Cusimano

Publikováno v: Biomacromolecules. 18(12)

Here, nano into micro formulations (NiMs) of tobramycin for the treatment of Pseudomonas aeruginosa airway infections in cystic fibrosis (CF) are described. NiMs were produced by spray drying a solution containing polymers or sugars and a nanometric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd3ad7c2de67f26dc682ca2dfef35a2
https://pubmed.ncbi.nlm.nih.gov/29111673