Assessment of bacterial exposure on phagocytic capability and surface marker expression of sputum macrophages and neutrophils in COPD patients

Autor: Simon Hall, Dave Singh, Edith M. Hessel, Simon Lea, Barbara Maschera, Rosemary Gaskell

Publikováno v: Clinical and Experimental Immunology
Lea, S, Gaskell, R & Singh, D 2021, ' Assessment of bacterial exposure on phagocytic capability and surface marker expression of sputum macrophages and neutrophils in COPD patients ', Clin.Exp.Immunol., vol. 206, no. 1, pp. 99-109 . https://doi.org/10.1111/cei.13638

Defective phagocytosis has been shown in chronic obstructive pulmonary disease (COPD) bronchoalveolar lavage and blood monocyte‐derived macrophages. Phagocytic capabilities of sputum macrophages and neutrophils in COPD are unknown. We investigated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286c8560cfce311d5ce7ae14bdbc4dbd
https://doi.org/10.1111/cei.13638

Airway host-microbiome interactions in chronic obstructive pulmonary disease

Autor: Stephanie Van Horn, Umme Kolsum, Dave Singh, Barbara Maschera, Christopher M. Traini, Zhang Wang, James R. Brown, Simon Lea, Edith M. Hessel, David Michalovich

Publikováno v: Respiratory Research
Respiratory Research, Vol 20, Iss 1, Pp 1-14 (2019)
Wang, Z, Maschera, B, Lea, S, Kolsum, U, Michalovich, D, Van Horn, S, Traini, C, Brown, J R, Hessel, E M & Singh, D 2019, ' Airway host-microbiome interactions in chronic obstructive pulmonary disease ', Respiratory research, vol. 20, no. 1, pp. 113 . https://doi.org/10.1186/s12931-019-1085-z

Background Little is known about the interactions between the lung microbiome and host response in chronic obstructive pulmonary disease (COPD). Methods We performed a longitudinal 16S ribosomal RNA gene-based microbiome survey on 101 sputum samples

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09da4312320ed1c104f8eb4e835a0a5
http://europepmc.org/articles/PMC6555748

Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor

Autor: Barbara Maschera, Keith Paul Ray, Jiirg Tschopp, Filippo Volpe, Laurence Martin, Chris Plumpton, Fabio Martinon, Kimberly Burns, Alan Peter Lewis, Jonathan Clatworthy

Publikováno v: Nature Cell Biology. 2:346-351

Interleukin-1 (IL-1) is a proinflammatory cytokine that elicits its pleiotropic effects through activation of the transcription factors NF-kappaB and AP-1. Binding of IL-1 to its receptor results in rapid assembly of a membrane-proximal signalling co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e8ea6f59fc9fc3aa870b7a895cc04b
https://doi.org/10.1038/35014038

The IL1 receptor accessory protein is responsible for the recruitment of the interleukin-1 receptor associated kinase to the IL1/IL1 receptor I complex

Autor: Allard Kaptein, Jonathan Clatworthy, Anne-Marie Griffin, Keith P. Ray, Barbara Maschera, Filippo Volpe

Publikováno v: FEBS Letters. 419:41-44

Following interleukin-1 (IL1) stimulation, an IL1 receptor associated kinase (IRAK) is rapidly recruited to the receptor complex. However, it is not understood if IRAK is able to interact directly with the intracellular portion of the IL1-RI or if it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4dff1ea173f01a8221e98e400d73c0
https://doi.org/10.1016/s0014-5793(97)01426-9

The Role Of Liver X Receptor In Chronic Obstructive Lung Disease

Autor: Jonathan Plumb, Barbara Maschera, Dave Singh, Andrew Higham, Karen D. Simpson, Simon Lea

Publikováno v: A32. HUMAN AND ANIMAL STUDIES OF CHRONIC DISEASES THAT AFFECT THE LUNG.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::236d8de8142f02efdcab18289b223bb5
https://doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a1328