Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Barbara, Lipinska"'
Autor:
Urszula Zarzecka, Anna Modrak-Wójcik, Donata Figaj, Malgorzata Apanowicz, Adam Lesner, Agnieszka Bzowska, Barbara Lipinska, Anna Zawilak-Pawlik, Steffen Backert, Joanna Skorko-Glonek
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
The protease high temperature requirement A from the gastric pathogen Helicobacter pylori (HtrAHp) belongs to the well conserved family of serine proteases. HtrAHp is an important secreted virulence factor involved in the disruption of tight and adhe
Externí odkaz:
https://doaj.org/article/366893ad318d464e97cc12623c9a4e21
Autor:
Dorota Zurawa-Janicka, Jarek Kobiela, Tomasz Slebioda, Rafal Peksa, Marcin Stanislawowski, Piotr Mieczyslaw Wierzbicki, Tomasz Wenta, Barbara Lipinska, Zbigniew Kmiec, Wojciech Biernat, Andrzej Jacek Lachinski, Zbigniew Sledzinski
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 11, p 3947 (2020)
HtrA proteases regulate cellular homeostasis and cell death. Their dysfunctions have been correlated with oncogenesis and response to therapeutic treatment. We investigated the relation between HtrA1-3 expression and clinicopathological, and survival
Externí odkaz:
https://doaj.org/article/d84a3bcd5dba4e778c339179d05e1f69
Publikováno v:
Cells, Vol 8, Iss 10, p 1112 (2019)
The HtrA4 human protease is crucial in placentation and embryo implantation, and its altered level is connected with pre-eclampsia. The meta-analyses of microarray assays revealed that the HtrA4 level is changed in brain tumors and breast and prostat
Externí odkaz:
https://doaj.org/article/388d6ca4ee2c4bd78d8c4f64dadae969
Autor:
Artur Gieldon, Dorota Zurawa-Janicka, Miroslaw Jarzab, Tomasz Wenta, Przemyslaw Golik, Grzegorz Dubin, Barbara Lipinska, Jerzy Ciarkowski
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161526 (2016)
HtrA2(Omi) protease controls protein quality in mitochondria and plays a major role in apoptosis. Its HtrA2S306A mutant (with the catalytic serine routinely disabled for an X-ray study to avoid self-degradation) is a homotrimer whose subunits contain
Externí odkaz:
https://doaj.org/article/0cede49dcda843cd9eae55c536739ae6
Autor:
Tomasz Koper, Agnieszka Polit, Anna Sobiecka-Szkatula, Katarzyna Wegrzyn, Andrea Scire, Donata Figaj, Leszek Kadzinski, Urszula Zarzecka, Dorota Zurawa-Janicka, Bogdan Banecki, Adam Lesner, Fabio Tanfani, Barbara Lipinska, Joanna Skorko-Glonek
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117413 (2015)
Bacterial HtrAs are proteases engaged in extracytoplasmic activities during stressful conditions and pathogenesis. A model prokaryotic HtrA (HtrA/DegP from Escherichia coli) requires activation to cleave its substrates efficiently. In the inactive st
Externí odkaz:
https://doaj.org/article/762f5b79782341b783e969b43e376bee
Autor:
Przemyslaw Glaza, Jerzy Osipiuk, Tomasz Wenta, Dorota Zurawa-Janicka, Miroslaw Jarzab, Adam Lesner, Bogdan Banecki, Joanna Skorko-Glonek, Andrzej Joachimiak, Barbara Lipinska
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131142 (2015)
Human HtrA3 protease, which induces mitochondria-mediated apoptosis, can be a tumor suppressor and a potential therapeutic target in the treatment of cancer. However, there is little information about its structure and biochemical properties. HtrA3 i
Externí odkaz:
https://doaj.org/article/bb04137a3fb540f39e835016e6aa5a31
Mast cells in mastocytosis and allergy – Important player in metabolic and immunological homeostasis
Autor:
Joanna Skorko-Glonek, Joanna Renke, Marek Niedoszytko, Eliza Wasilewska, Anna Liberek, Sabina Kędzierska-Mieszkowska, Jacek M. Witkowski, Marcin Renke, Barbara Lipinska, Magdalena Lange, Bogusław Nedoszytko
Publikováno v:
Advances in Medical Sciences. 64:124-130
The role of mast cell (MC) activity in pathophysiology is complex and challenging and its clinical effects are difficult to predict. Apart from the known role of MCs in basic immunological processes and allergy, underlined is their importance in bone
Autor:
Sabina Kędzierska-Mieszkowska, Danuta Siluk, Aleksandra Szczepankiewicz, Dorota Żurawa-Janicka, Sylwia Barańska, Anna Liberek, Eliza Wasilewska, Joanna Renke, Marcin Renke, Tomasz Wenta, Barbara Lipinska, Katarzyna Zorena
Publikováno v:
Medicina
Volume 56
Issue 6
Medicina; Volume 56; Issue 6; Pages: 298
Medicina, Vol 56, Iss 298, p 298 (2020)
Volume 56
Issue 6
Medicina; Volume 56; Issue 6; Pages: 298
Medicina, Vol 56, Iss 298, p 298 (2020)
Background and objective: Allergy belongs to a group of mast cell-related disorders and is one of the most common diseases of childhood. It was shown that asthma and allergic rhinitis diminish the risk of various cancers, including colon cancer and a
Autor:
Miroslaw Jarzab, Krystyna Bieńkowska-Szewczyk, Anna Herman-Antosiewicz, Tomasz Wenta, Przemyslaw Glaza, Barbara Lipinska, Dorota Zurawa-Janicka, Joanna Skorko-Glonek, Michał Rychłowski, Andrea D. Lipińska
Publikováno v:
Journal of Proteomics. 177:88-111
The human HtrA3 protease is involved in placentation, mitochondrial homeostasis, stimulation of apoptosis and proposed to be a tumor suppressor. Molecular mechanisms of the HtrA3 functions are poorly understood and knowledge concerning its cellular t
Autor:
Kamila Sychowska, Łukasz Winiarski, Mirosław Jarząb, Marcin Skoreński, Mateusz Psurski, Przemyslaw Glaza, Marcin Sieńczyk, Adam Lesner, Artur Giełdoń, Barbara Lipinska, Tomasz Wenta, Natalia Gruba, Magdalena Wysocka, Joanna Makowska, Joanna Zdancewicz
Publikováno v:
ACS Combinatorial Science. 19:565-573
Herein, we report selection, synthesis, and enzymatic evaluation of a peptidomimetic library able to increase proteolytic activity of HtrA3 (high temperature requirement A) protease. Iterative deconvolution in solution of synthesized modified pentape