Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Barbara, Cervasi"'
Autor:
Maria Pino, Amélie Pagliuzza, M. Betina Pampena, Claire Deleage, Elise G. Viox, Kevin Nguyen, Inbo Shim, Adam Zhang, Justin L. Harper, Sadia Samer, Colin T. King, Barbara Cervasi, Kiran P. Gill, Stephanie Ehnert, Sherrie M. Jean, Michael L. Freeman, Jeffrey D. Lifson, Deanna Kulpa, Michael R. Betts, Nicolas Chomont, Michael M. Lederman, Mirko Paiardini
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Although antiretroviral therapy (ART) is able to successfully suppress plasma viremia in most people living with HIV, ART withdrawal typically results in viral replication and rebound. Authors investigate the effect, in terms of delay in viral replic
Externí odkaz:
https://doaj.org/article/02897c95d48247e0867184e05e8cc7b9
Autor:
Zachary Strongin, Timothy N Hoang, Gregory K Tharp, Andrew R Rahmberg, Justin L Harper, Kevin Nguyen, Lavinia Franchitti, Barbara Cervasi, Max Lee, Zhan Zhang, Eli A Boritz, Guido Silvestri, Vincent C Marconi, Steven E Bosinger, Jason M Brenchley, Deanna A Kulpa, Mirko Paiardini
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010723 (2022)
Despite the advent of effective antiretroviral therapy (ART), human immunodeficiency virus (HIV) continues to pose major challenges, with extensive pathogenesis during acute and chronic infection prior to ART initiation and continued persistence in a
Externí odkaz:
https://doaj.org/article/0d173f19d60843dc8264274e0962880c
Autor:
Justin Harper, Susan P. Ribeiro, Chi Ngai Chan, Malika Aid, Claire Deleage, Luca Micci, Maria Pino, Barbara Cervasi, Gopalan Raghunathan, Eric Rimmer, Gulesi Ayanoglu, Guoxin Wu, Neeta Shenvi, Richard J.O. Barnard, Gregory Q. Del Prete, Kathleen Busman-Sahay, Guido Silvestri, Deanna A. Kulpa, Steven E. Bosinger, Kirk A. Easley, Bonnie J. Howell, Dan Gorman, Daria J. Hazuda, Jacob D. Estes, Rafick-Pierre Sekaly, Mirko Paiardini
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 8 (2022)
Interleukin-10 (IL-10) is an immunosuppressive cytokine that signals through STAT3 to regulate T follicular helper (Tfh) cell differentiation and germinal center formation. In SIV-infected macaques, levels of IL-10 in plasma and lymph nodes (LNs) wer
Externí odkaz:
https://doaj.org/article/3c551d2d1a814a3d84819bbd3a685652
Autor:
Michelle Y-H Lee, Amit A Upadhyay, Hasse Walum, Chi N Chan, Reem A Dawoud, Christine Grech, Justin L Harper, Kirti A Karunakaran, Sydney A Nelson, Ernestine A Mahar, Kyndal L Goss, Diane G Carnathan, Barbara Cervasi, Kiran Gill, Gregory K Tharp, Elizabeth R Wonderlich, Vijayakumar Velu, Simon M Barratt-Boyes, Mirko Paiardini, Guido Silvestri, Jacob D Estes, Steven E Bosinger
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009674 (2021)
HIV associated immune activation (IA) is associated with increased morbidity in people living with HIV (PLWH) on antiretroviral therapy, and remains a barrier for strategies aimed at reducing the HIV reservoir. The underlying mechanisms of IA have no
Externí odkaz:
https://doaj.org/article/23f45ec77beb4055b59259a74d913d13
Autor:
Maria Pino, Sara Paganini, Claire Deleage, Kartika Padhan, Justin L Harper, Colin T King, Luca Micci, Barbara Cervasi, Joseph C Mudd, Kiran P Gill, Sherrie M Jean, Kirk Easley, Guido Silvestri, Jacob D Estes, Constantinos Petrovas, Michael M Lederman, Mirko Paiardini
Publikováno v:
PLoS Pathogens, Vol 15, Iss 10, p e1008081 (2019)
Lymph nodes (LN) and their resident T follicular helper CD4+ T cells (Tfh) are a critical site for HIV replication and persistence. Therefore, optimizing antiviral activity in lymphoid tissues will be needed to reduce or eliminate the HIV reservoir.
Externí odkaz:
https://doaj.org/article/317b112ab6a540088ba22b5560bb1102
Autor:
Sadia Samer, Ankita Chowdhury, Tomas Raul Wiche Salinas, Perla M. Del Rio Estrada, Morgan Reuter, Gregory Tharp, Steven Bosinger, Barbara Cervasi, James Auger, Kiran Gill, Yuria Ablanedo-Terrazas, Gustavo Reyes-Teran, Jacob D. Estes, Michael R. Betts, Guido Silvestri, Mirko Paiardini
Publikováno v:
Journal of Virology.
The HIV reservoir is largely composed of latently infected memory CD4 + T cells that persist during antiretroviral therapy and constitute a major barrier toward HIV eradication. In particular, CD4 + T follicular helper cells have been demonstrated as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88f30e5e2c8adf3f42aaf19514705d7a
https://doi.org/10.1128/jvi.01760-22
https://doi.org/10.1128/jvi.01760-22
Autor:
Christina Mallarino-Haeger, Maria Pino, Elise G. Viox, Amélie Pagliuzza, Colin T. King, Kevin Nguyen, Justin L. Harper, Sol del Mar Aldrete, Barbara Cervasi, Keith A. Delman, Michael C. Lowe, Nicolas Chomont, Vincent C. Marconi, Mirko Paiardini
Publikováno v:
Journal of Virology. 97
This study provides new insights into the contributions of different CD4 + and CD8 + T-cell subsets to the anatomic differences between LN and blood in individuals with HIV who have optimal versus suboptimal CD4 + T-cell recovery. To our knowledge, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48027c9f383f8a4cf4aab5b8bb4921a1
https://doi.org/10.1128/jvi.01670-22
https://doi.org/10.1128/jvi.01670-22
Autor:
Jenna Read, Colin T. King, Maria Pino, Mirko Paiardini, Heather Amrine-Madsen, Michael Nekorchuk, Chi Ngai Chan, Cristin M. Galardi, Hong Wang, James Schawalder, Katharine J. Bar, A. Alicia Koblansky, Colleen S. McGary, Kevin Nguyen, Jacob D. Estes, Sherrie Jean, Samuel L. M. Raines, Shane D. Falcinelli, Jeffrey D. Lifson, Shari Gordon, Luca Micci, Guido Silvestri, Andrew Sanderson, Justin L. Harper, Brian Johns, David Favre, Emily Lindemuth, Kathleen Busman-Sahay, Barbara Cervasi, David M. Margolis
Publikováno v:
Nature Medicine. 26:519-528
The primary human immunodeficiency virus (HIV) reservoir is composed of resting memory CD4+ T cells, which often express the immune checkpoint receptors programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte-associated protein 4 (CTLA-4),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::312fadfaa081c57663b7be6786d965d1
https://doi.org/10.1038/s41591-020-0782-y
https://doi.org/10.1038/s41591-020-0782-y
Autor:
Justin Harper, Susan P. Ribeiro, Chi Ngai Chan, Malika Aid, Claire Deleage, Luca Micci, Maria Pino, Barbara Cervasi, Gopalan Raghunathan, Eric Rimmer, Gulesi Ayanoglu, Guoxin Wu, Neeta Shenvi, Richard J.O. Barnard, Gregory Q. Del Prete, Kathleen Busman-Sahay, Guido Silvestri, Deanna A. Kulpa, Steven E. Bosinger, Kirk A. Easley, Bonnie J. Howell, Dan Gorman, Daria J. Hazuda, Jacob D. Estes, Rafick-Pierre Sekaly, Mirko Paiardini
Publikováno v:
The Journal of clinical investigation. 132(8)
Interleukin-10 (IL-10) is an immunosuppressive cytokine that signals through STAT3 to regulate T follicular helper (Tfh) cell differentiation and germinal center formation. In SIV-infected macaques, levels of IL-10 in plasma and lymph nodes (LNs) wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d087014e3ecae8c172e5cd6e4002a185
https://pubmed.ncbi.nlm.nih.gov/35230978
https://pubmed.ncbi.nlm.nih.gov/35230978
Autor:
Simon M. Barratt-Boyes, Steven E. Bosinger, Gregory K. Tharp, Chi N. Chan, Justin L. Harper, Amit A. Upadhyay, Elizabeth R. Wonderlich, Kirti A. Karunakaran, Guido Silvestri, Kiran Gill, Diane G. Carnathan, Reem A. Dawoud, Ernestine A. Mahar, Jacob D. Estes, Sydney A. Nelson, Vijayakumar Velu, Michelle Y.H. Lee, Barbara Cervasi, Hasse Walum, Kyndal L. Goss, Christine Grech, Mirko Paiardini
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009674 (2021)
PLoS Pathogens
PLoS Pathogens
HIV associated immune activation (IA) is associated with increased morbidity in people living with HIV (PLWH) on antiretroviral therapy, and remains a barrier for strategies aimed at reducing the HIV reservoir. The underlying mechanisms of IA have no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c158b05d4ea939c3eddbce43f6a43888
https://doaj.org/article/23f45ec77beb4055b59259a74d913d13
https://doaj.org/article/23f45ec77beb4055b59259a74d913d13