Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Barbara, Brodsky"'
Autor:
Hina Iqbal, Ka Wai Fung, Jayesh Gor, Anthony C. Bishop, George I. Makhatadze, Barbara Brodsky, Stephen J. Perkins
Publikováno v:
Journal of Biological Chemistry. 299:102799
Collagen triple helices are critical in the function of mannan-binding lectin (MBL), an oligomeric recognition molecule in complement activation. The MBL collagen regions form complexes with the serine proteases MASP-1 and MASP-2 in order to activate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237bd10a70036a5e97c63a0803b07439
https://doi.org/10.1016/j.jbc.2022.102799
https://doi.org/10.1016/j.jbc.2022.102799
Autor:
Barbara Brodsky, David L. Kaplan, Erik Poppleton, Hideaki Nagase, Robert Visse, Arya Mekkat, Bo An, Yu-Shan Lin
Publikováno v:
Journal of Structural Biology. 203:247-254
Cleavage of collagen by collagenases such as matrix metalloproteinase 1 (MMP-1) is a key step in development, tissue remodeling, and tumor proliferation. The abundant heterotrimeric type I collagen composed of two α1(I) chains and one α2(I) chain i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50035c6b5437b08d5be79f08ff4e4d5f
https://doi.org/10.1016/j.jsb.2018.05.002
https://doi.org/10.1016/j.jsb.2018.05.002
Publikováno v:
Journal of Biological Chemistry. 291:27073-27086
Collagen and fibronectin (Fn) are two key extracellular matrix proteins, which are known to interact and jointly shape matrix structure and function. Most proteins that interact with collagen bind only to the native triple-helical form, whereas Fn is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bda8549bc362753c7a35caf44b02996
https://doi.org/10.1074/jbc.m116.753566
https://doi.org/10.1074/jbc.m116.753566
Publikováno v:
Advanced Drug Delivery Reviews. 97:69-84
Collagen is a major component in a wide range of drug delivery systems and biomaterial applications. Its basic physical and structural properties, together with its low immunogenicity and natural turnover, are keys to its biocompatibility and effecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a30a0010e150593069300bcacf1b45
https://doi.org/10.1016/j.addr.2015.11.013
https://doi.org/10.1016/j.addr.2015.11.013
Autor:
Yu-Shan Lin, Erik Poppleton, Hongtao Yu, Sandra E. Wiley, Yimin Qiu, Sourav Banerjee, Barbara Brodsky, David L. Kaplan, Jack E. Dixon, Arya Mekkat
Publikováno v:
Biophysical journal. 115(12)
Phosphoproteomics studies have reported phosphorylation at multiple sites within collagen, raising the possibility that these post-translational modifications regulate the physical or biological properties of collagen. In this study, molecular dynami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b3427f1d19411f89e315d8edfa22a2
https://pubmed.ncbi.nlm.nih.gov/30527445
https://pubmed.ncbi.nlm.nih.gov/30527445
Publikováno v:
Collagen ISBN: 9781351070799
This chapter reviews the areas of collagen structure which have been analyzed by X-ray diffraction and to examine questions at various levels of connective tissue organization that may be resolved by X-ray studies. X-ray diffraction is a tool capable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::092c8e03c15eb2270057316e64ee30dd
https://doi.org/10.1201/9781351070799-3
https://doi.org/10.1201/9781351070799-3
Autor:
Richard W. Farndale, Yu-Shan Lin, Barbara Brodsky, Yimin Qiu, Samir W. Hamaia, Sezin Yigit, Hongtao Yu, David L. Kaplan, Arya Mekkat
Publikováno v:
Journal of structural biology. 203(3)
Gly missense mutations in type I collagen, which replace a conserved Gly in the repeating (Gly-Xaa-Yaa)(n) sequence with a larger residue, are known to cause Osteogenesis Imperfecta (OI). The clinical consequences of such mutations range from mild to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f8333261cbc258c6b35afb4a241dfdf
https://pubmed.ncbi.nlm.nih.gov/29758270
https://pubmed.ncbi.nlm.nih.gov/29758270
Autor:
Barbara, Brodsky, John A M, Ramshaw
Publikováno v:
Sub-cellular biochemistry. 82
There is a great deal of interest in obtaining recombinant collagen as an alternative source of material for biomedical applications and as an approach for obtaining basic structural and biological information. However, application of recombinant tec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::870e4dadde495d0ea1a1a307084fcb07
https://pubmed.ncbi.nlm.nih.gov/28101874
https://pubmed.ncbi.nlm.nih.gov/28101874
Autor:
Barbara Brodsky, John A. M. Ramshaw
Publikováno v:
Subcellular Biochemistry ISBN: 9783319496726
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2c29f8b7ca329bad297c1eb34d7fd26
https://doi.org/10.1007/978-3-319-49674-0_18
https://doi.org/10.1007/978-3-319-49674-0_18
Publikováno v:
Biochemistry and Molecular Biology Education. 42:259-269
The rationale for this mandatory, guided online e-journal exercise is to foster the ability of students to independently read medical and scientific literature in a critical manner and to integrate journal reading with their basic science knowledge.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c450152e6abf8097c754157e87986a73
https://doi.org/10.1002/bmb.20785
https://doi.org/10.1002/bmb.20785