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Delayed administration of ixazomib modifies the immune response and prevents chronic graft-versus-host disease

Autor: Teresa L. Ramos, Alfonso Rodríguez-Gil, José Antonio Pérez-Simón, Melanie Nufer, Teresa Caballero-Velázquez, Estefanía García-Guerrero, María Victoria Barbado, Rocío Caracuel-García, María José Robles-Frías

Publikováno v: Bone Marrow Transplantation
Digital.CSIC. Repositorio Institucional del CSIC
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In this study, we aimed to modify the immune response in the long term after allogeneic bone marrow transplantation (allo-BMT) by using the proteasome inhibitor ixazomib (IXZ) at the late stages of the post-transplant period. This approach facilitate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227fcab3b1ab31aee8f3643f5967ee34
https://doi.org/10.1038/s41409-021-01452-1

Polyphenolic Extract (PE) from Olive Oil Exerts a Potent Immunomodulatory Effect and Prevents Graft-versus-Host Disease in a Mouse Model.

Autor: Alvarez-Laderas I; Department of Hematology, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Seville, Spain., Ramos TL; Department of Hematology, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Seville, Spain., Medrano M; Department of Hematology, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Seville, Spain., Caracuel-García R; Department of Hematology, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Seville, Spain., Barbado MV; Department of Hematology, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Seville, Spain., Sánchez-Hidalgo M; Department of Pharmacology, Faculty of Pharmacy, Universidad de Sevilla, Seville, Spain., Zamora R; Instituto de la Grasa, Consejo Superior de Investigaciones Científicas, Campus Universitario-Edificio 46, Seville, Spain., Alarcón-de-la-Lastra C; Department of Pharmacology, Faculty of Pharmacy, Universidad de Sevilla, Seville, Spain., Hidalgo FJ; Instituto de la Grasa, Consejo Superior de Investigaciones Científicas, Campus Universitario-Edificio 46, Seville, Spain., Piruat JI; Department of Hematology, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Seville, Spain., Caballero-Velázquez T; Department of Hematology, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Seville, Spain., Pérez-Simón JA; Department of Hematology, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Seville, Spain. Electronic address: josea.perez.simon.sspa@juntadeandalucia.es.

Publikováno v: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [Biol Blood Marrow Transplant] 2020 Apr; Vol. 26 (4), pp. 615-624. Date of Electronic Publication: 2019 Nov 19.

Myelomatous plasma cells display an aberrant gene expression pattern similar to that observed in normal memory B cells.

Autor: Báez A; Department of Hematology, University Hospital Virgen del Rocío, Institute of Biomedicine of Seville (IBIS), CSIC, Universidad de Sevilla Seville, Spain., Piruat JI; Department of Hematology, University Hospital Virgen del Rocío, Institute of Biomedicine of Seville (IBIS), CSIC, Universidad de Sevilla Seville, Spain., Caballero-Velázquez T; Department of Hematology, University Hospital Virgen del Rocío, Institute of Biomedicine of Seville (IBIS), CSIC, Universidad de Sevilla Seville, Spain., Sánchez-Abarca LI; Department of Hematology, University Hospital Virgen del Rocío, Institute of Biomedicine of Seville (IBIS), CSIC, Universidad de Sevilla Seville, Spain., Álvarez-Laderas I; Department of Hematology, University Hospital Virgen del Rocío, Institute of Biomedicine of Seville (IBIS), CSIC, Universidad de Sevilla Seville, Spain., Barbado MV; Department of Hematology, University Hospital Virgen del Rocío, Institute of Biomedicine of Seville (IBIS), CSIC, Universidad de Sevilla Seville, Spain., García-Guerrero E; Department of Hematology, University Hospital Virgen del Rocío, Institute of Biomedicine of Seville (IBIS), CSIC, Universidad de Sevilla Seville, Spain., Millán-Uclés Á; Department of Hematology, University Hospital Virgen del Rocío, Institute of Biomedicine of Seville (IBIS), CSIC, Universidad de Sevilla Seville, Spain., Martín-Sánchez J; Department of Hematology, University Hospital Virgen del Rocío, Institute of Biomedicine of Seville (IBIS), CSIC, Universidad de Sevilla Seville, Spain., Medrano M; Department of Hematology, University Hospital Virgen del Rocío, Institute of Biomedicine of Seville (IBIS), CSIC, Universidad de Sevilla Seville, Spain., Pérez-Simón JA; Department of Hematology, University Hospital Virgen del Rocío, Institute of Biomedicine of Seville (IBIS), CSIC, Universidad de Sevilla Seville, Spain.

Publikováno v: American journal of cancer research [Am J Cancer Res] 2014 Dec 15; Vol. 5 (1), pp. 386-95. Date of Electronic Publication: 2014 Dec 15 (Print Publication: 2015).

Gene and miRNA expression profiles of hematopoietic progenitor cells vary depending on their origin.

Autor: Báez A; Department of Hematology, University Hospital Virgen del Rocio/Institute of Biomedicine of Seville (IBIS)/CSIC/University of Seville. Electronic address: abaez-ibis@us.es., Martín-Antonio B; Department of Hematology/Hospital Clinic/IDIBAPS and Institute of Research Josep Carreras/University of Barcelona., Piruat JI; Department of Hematology, University Hospital Virgen del Rocio/Institute of Biomedicine of Seville (IBIS)/CSIC/University of Seville., Barbado MV; Department of Hematology, University Hospital Virgen del Rocio/Institute of Biomedicine of Seville (IBIS)/CSIC/University of Seville., Prats C; Department of Hematology, University Hospital Virgen del Rocio/Institute of Biomedicine of Seville (IBIS)/CSIC/University of Seville., Álvarez-Laderas I; Department of Hematology, University Hospital Virgen del Rocio/Institute of Biomedicine of Seville (IBIS)/CSIC/University of Seville., Carmona M; Department of Hematology, University Hospital Virgen del Rocio/Institute of Biomedicine of Seville (IBIS)/CSIC/University of Seville., Pérez-Simón JA; Department of Hematology, University Hospital Virgen del Rocio/Institute of Biomedicine of Seville (IBIS)/CSIC/University of Seville., Urbano-Ispizua Á; Department of Hematology/Hospital Clinic/IDIBAPS and Institute of Research Josep Carreras/University of Barcelona.

Publikováno v: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [Biol Blood Marrow Transplant] 2014 May; Vol. 20 (5), pp. 630-9. Date of Electronic Publication: 2014 Jan 23.