Výsledky vyhledávání - "Barb E. Segelstein"

Design, synthesis and biological evaluation of 3-amino-3-phenylpropionamide derivatives as novel μ opioid receptor ligands

Autor: Dianne K. Bryce, Martin Patrick Allen, Spiros Liras, Stafford McLean, Mary E. Haggan, Barb E. Segelstein, James F. Blake

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 10:523-526

3-Amino-3-phenylpropionamide derivatives were produced as small molecule mimics of the cyclic octapeptide octreotide from readily available imine 1 Download : Download high-res image (51KB) Download : Download full-size image Scheme 1 . Preparation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b6523a05d5873681cffe2d88ffb6ff8
https://doi.org/10.1016/s0960-894x(00)00034-2

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A Mild Method for the Preparation of 1,3,4-Oxadiazoles: Triflic Anhydride Promoted Cyclization of Diacylhydrazines

Autor: Barb E. Segelstein, Martin Patrick Allen, Spiros Liras

Publikováno v: Synthetic Communications. 30:437-443

Diacylhydrazines undergo cyclization upon treatment with triflic anhydride and pyridine to form the corresponding 1,3,4-oxadiazoles in yields ranging from 70--95%.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f551230b1bacf2997f17675bfc11908
https://doi.org/10.1080/00397910008087340

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Expanding the medicinal chemistry toolbox: stereospecific generation of methyl group-containing propylene linkers

Autor: Fliri Anton F J, Kristopher Bosse, Robert A. Volkmann, Deane M. Nason, Barb E. Segelstein, Jason Marineau, Desai Kishor A

Publikováno v: Tetrahedron Letters. 47:7285-7287

Use of alkyl substituted propylene linkers as a strategy for fine-tuning the biological activity of medicinal agents requires ready access to these substrates. Herein, a general strategy is described for stereospecifically generating 18 chiral mono-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0a80ccbffdb352df9b761d40d911b49
https://doi.org/10.1016/j.tetlet.2006.08.020

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Ethoxymethylenemalonates and Malononitriles (EMM reagents) as formic acid equivalents: Synthesis of fused-imidazoles under neutral or mildly acidic con

Autor: Macor John E, Bert L. Chenard, Ronald J. Post, Barb E. Segelstein

Publikováno v: Tetrahedron Letters. 34:1897-1900

The use of ethoxymethylenemalonates and malononitriles (EMM reagents) for the efficient synthesis of fused imidazoles and related compounds is describe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6252e72649ba305d3adb635c2189a198
https://doi.org/10.1016/s0040-4039(00)91957-9

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ChemInform Abstract: A Mild Method for the Preparation of 1,3,4-Oxadiazoles: Triflic Anhydride Promoted Cyclization of Diacylhydrazines

Autor: Barb E. Segelstein, Spiros Liras, Martin Patrick Allen

Publikováno v: ChemInform. 31

Diacylhydrazines undergo cyclization upon treatment with triflic anhydride and pyridine to form the corresponding 1,3,4-oxadiazoles in yields ranging from 70--95%.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5441402e5c0ef660e3718a896ee7f15e
https://doi.org/10.1002/chin.200024129

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ChemInform Abstract: Design, Synthesis, and Biological Evaluation of 3-Amino-3-phenylpropionamide Derivatives as Novel μ Opioid Receptor Ligands

Autor: Spiros Liras, Barb E. Segelstein, Martin Patrick Allen, Stafford McLean, Dianne K. Bryce, James F. Blake, Mary E. Haggan

Publikováno v: ChemInform. 31

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f293bcb784c043598bc991136edd138b
https://doi.org/10.1002/chin.200028087

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Biaryl piperidines as potent and selective delta opioid receptor ligands

Autor: Anne W. Schmidt, Barb E. Segelstein, Michelle Vanase-Frawley, Steven D. Heck, Stanton F. McHardy, Ernesto Callegari, Dianne K. Bryce, Spiros Liras, Martin Patrick Allen, Stafford McLean

Publikováno v: Bioorganicmedicinal chemistry letters. 20(2)

The design and synthesis of novel opiates are reported. Based on the message-address principle a novel class of 4,4- and 3,3-biaryl piperidines was designed and synthesized. Biological evaluation confirmed that these compounds exhibit high affinity a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e7e3345b535f1b8cbf1ae9ba40ced7
https://pubmed.ncbi.nlm.nih.gov/20015649

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