A Programmable In Vivo CRISPR Activation Model Elucidates the Oncogenic and Immunosuppressive Functions of MYC in Lung Adenocarcinoma.

Autor: Thege FI; Ahmed Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Department of Translational Molecular Pathology, MD Anderson Cancer Center, University of Texas, Houston, Texas., Rupani DN; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas., Barathi BB; Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas., Manning SL; Ahmed Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas., Maitra A; Ahmed Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Department of Translational Molecular Pathology, MD Anderson Cancer Center, University of Texas, Houston, Texas., Rhim AD; Ahmed Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas., Wörmann SM; Ahmed Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Department of Translational Molecular Pathology, MD Anderson Cancer Center, University of Texas, Houston, Texas.

Publikováno v: Cancer research [Cancer Res] 2022 Aug 03; Vol. 82 (15), pp. 2761-2776.