Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Barath Shreeder"'
Autor:
Emmanuel M. Gabriel, Brian Necela, Deborah Bahr, Sneha Vivekanandhan, Barath Shreeder, Sanjay Bagaria, Keith L. Knutson
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract In this study, we tested a novel approach of “repurposing” a biomarker typically associated with breast cancer for use in melanoma. HER2/neu is a well characterized biomarker in breast cancer for which effective anti-HER2/neu therapies a
Externí odkaz:
https://doaj.org/article/15cf9697167549baa914c2e9e20348c7
Autor:
Yi Lin, Yan W Asmann, Barath Shreeder, Keith L Knutson, Erik Jessen, Daniel P Wickland, Colton McNinch, Brian Necela
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 5 (2024)
Background Cancer neoantigens arise from protein-altering somatic mutations in tumor and rank among the most promising next-generation immuno-oncology agents when used in combination with immune checkpoint inhibitors. We previously developed a comput
Externí odkaz:
https://doaj.org/article/bf5610643ea74733ae707eb219999a5b
Autor:
Yan Luo, Matthew S Block, Barath Shreeder, James W Jenkins, Huashan Shi, Purushottam Lamichhane, Kexun Zhou, Deborah A Bahr, Sophia Kurian, Katherine A Jones, Joshua I Daum, Navnita Dutta, Brian M Necela, Martin J Cannon, Keith L Knutson
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 11 (2023)
Background Ovarian cancer (OC), a highly lethal cancer in women, has a 48% 5-year overall survival rate. Prior studies link the presence of IL-17 and Th17 T cells in the tumor microenvironment to improved survival in OC patients. To determine if Th17
Externí odkaz:
https://doaj.org/article/c7f089de207141e2ac20f5bd2a7c68ba
Autor:
Edith A. Perez, Elizabeth A. Mittendorf, Mark Pegram, Carmen Calfa, Winston Tan, Donald Northfelt, Nadine Norton, Courtney L. Erskine, Kathleen S. Tenner, Karla Ballman, Kathleen P. Kemp, Patrick Yeramian, Barath Shreeder, Raphael Clynes, Keith L. Knutson
Supplementary Figure S1 describes the pre-existing antibody responses to tumor antigens in patients with surgically resected HER2+ breast cancer. Supplementary Figure S2 compares the proportion of either the metastatic or adjuvant patients that respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7171c1fe5ead828e1ba4f2f22094ed61
https://doi.org/10.1158/0008-5472.22412151.v1
https://doi.org/10.1158/0008-5472.22412151.v1
Autor:
Keith L. Knutson, Martin J. Cannon, Matthew S. Block, Ellen L. Goode, Kimberly R. Kalli, Joshua Daum, Deborah Bahr, James Krempski, Barath Shreeder, Lavakumar Karyampudi, Purushottam Lamichhane
Expression of PD-1 on BMDCs and T cells after exposure to IL-6 and IL-10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41564667fab3bf2525b49273bfdd665b
https://doi.org/10.1158/0008-5472.22416429.v1
https://doi.org/10.1158/0008-5472.22416429.v1
Autor:
Keith L. Knutson, Glynn Wilson, Toni K. Mangskau, Dan W. Visscher, Danell Puglisi-Knutson, Barath Shreeder, Michael P. Gustafson, Douglas Padley, Allan Dietz, Timothy J. Hobday, Courtney L. Erskine, Pashtoon M. Kasi, Matthew S. Block, Kimberly R. Kalli
Purpose: Folate receptor alpha (FR) is overexpressed in several cancers. Endogenous immunity to the FR has been demonstrated in patients and suggests the feasibility of targeting FR with vaccine or other immune therapies. CD4 helper T cells are centr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005a61eca386f1f6a312d8974f4d746d
https://doi.org/10.1158/1078-0432.c.6525873.v1
https://doi.org/10.1158/1078-0432.c.6525873.v1
Autor:
Edith A. Perez, Elizabeth A. Mittendorf, Mark Pegram, Carmen Calfa, Winston Tan, Donald Northfelt, Nadine Norton, Courtney L. Erskine, Kathleen S. Tenner, Karla Ballman, Kathleen P. Kemp, Patrick Yeramian, Barath Shreeder, Raphael Clynes, Keith L. Knutson
The addition of trastuzumab to chemotherapy extends survival among patients with HER2+ breast cancer. Prior work showed that trastuzumab and chemotherapy augments HER2 extracellular domain (ECD)-specific antibodies. The current study investigated whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2142aacfa9480e56b1afecd61b3fae47
https://doi.org/10.1158/0008-5472.c.6508374.v1
https://doi.org/10.1158/0008-5472.c.6508374.v1
Autor:
Keith L. Knutson, Glynn Wilson, Toni K. Mangskau, Dan W. Visscher, Danell Puglisi-Knutson, Barath Shreeder, Michael P. Gustafson, Douglas Padley, Allan Dietz, Timothy J. Hobday, Courtney L. Erskine, Pashtoon M. Kasi, Matthew S. Block, Kimberly R. Kalli
Figure S1: Vaccination generates T cell immunity to FR following immunization.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4d9ca6f044717cade2c01f98f9c51b
https://doi.org/10.1158/1078-0432.22464954.v1
https://doi.org/10.1158/1078-0432.22464954.v1
Autor:
Keith L. Knutson, Martin J. Cannon, Matthew S. Block, Ellen L. Goode, Kimberly R. Kalli, Joshua Daum, Deborah Bahr, James Krempski, Barath Shreeder, Lavakumar Karyampudi, Purushottam Lamichhane
Ligation of programmed cell death-1 (PD-1) in the tumor microenvironment is known to inhibit effective adaptive antitumor immunity. Blockade of PD-1 in humans has resulted in impressive, durable regression responses in select tumor types. However, du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1526fefa0d977e5e6e0f4eda9487c73
https://doi.org/10.1158/0008-5472.c.6509550
https://doi.org/10.1158/0008-5472.c.6509550
Autor:
Keith L. Knutson, Marshall D. Behrens, James W. Krempski, Barath Shreeder, Kimberly R. Kalli, Adam D. Scheid, Purushottam Lamichhane, Lavakumar Karyampudi
PDF file - 418KB, Supplementary Methods and Results Fig. S1. In vitro blockade of PD-1 on TUBO cells does not inhibit cell growth. Fig. S2. CD4 T cells and CD4 Tregs in TUBO TILs. Fig. S3. Combination therapy enhances the antigen-specific function of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e885b622929699327136bd90f11207f
https://doi.org/10.1158/0008-5472.22398798.v1
https://doi.org/10.1158/0008-5472.22398798.v1