Sculpting the tumour microenvironment by combining radiotherapy and ATR inhibition for curative-intent adjuvant immunotherapy.

Autor: Patin EC; Targeted Therapy Team, The Institute of Cancer Research, London, UK. emmanuel.patin@icr.ac.uk., Nenclares P; Targeted Therapy Team, The Institute of Cancer Research, London, UK.; The Royal Marsden Hospital, London, UK., Chan Wah Hak C; Targeted Therapy Team, The Institute of Cancer Research, London, UK.; The Royal Marsden Hospital, London, UK., Dillon MT; Targeted Therapy Team, The Institute of Cancer Research, London, UK.; The Royal Marsden Hospital, London, UK., Patrikeev A; Targeted Therapy Team, The Institute of Cancer Research, London, UK., McLaughlin M; Targeted Therapy Team, The Institute of Cancer Research, London, UK., Grove L; Targeted Therapy Team, The Institute of Cancer Research, London, UK.; The Royal Marsden Hospital, London, UK., Foo S; Targeted Therapy Team, The Institute of Cancer Research, London, UK., Soliman H; The Royal Marsden Hospital, London, UK., Barata JP; The Royal Marsden Hospital, London, UK., Marsden J; The Royal Marsden Hospital, London, UK., Baldock H; Targeted Therapy Team, The Institute of Cancer Research, London, UK., Gkantalis J; Targeted Therapy Team, The Institute of Cancer Research, London, UK., Roulstone V; Targeted Therapy Team, The Institute of Cancer Research, London, UK., Kyula J; Targeted Therapy Team, The Institute of Cancer Research, London, UK., Burley A; Targeted Therapy Team, The Institute of Cancer Research, London, UK., Hubbard L; Targeted Therapy Team, The Institute of Cancer Research, London, UK., Pedersen M; Targeted Therapy Team, The Institute of Cancer Research, London, UK., Smith SA; Early Oncology R&D, AstraZeneca, Cambridge, UK., Clancy-Thompson E; Early Oncology R&D, AstraZeneca, Cambridge, UK., Melcher AA; Translational Immunotherapy Team, The Institute of Cancer Research, London, UK., Ono M; Department of Life Sciences, Imperial College London, London, UK., Rullan A; Targeted Therapy Team, The Institute of Cancer Research, London, UK.; The Royal Marsden Hospital, London, UK., Harrington KJ; Targeted Therapy Team, The Institute of Cancer Research, London, UK.; The Royal Marsden Hospital, London, UK.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 13; Vol. 15 (1), pp. 6923. Date of Electronic Publication: 2024 Aug 13.