Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Barak A. Cohen"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract A key question in regulatory genomics is whether cis-regulatory elements (CREs) are modular elements that can function anywhere in the genome, or whether they are adapted to certain genomic locations. To distinguish between these possibiliti
Externí odkaz:
https://doaj.org/article/5493e21bd1fc4598b807a433f55e8a0a
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-23 (2024)
Abstract Background Individual cells from isogenic populations often display large cell-to-cell differences in gene expression. This “noise” in expression derives from several sources, including the genomic and cellular environment in which a gen
Externí odkaz:
https://doaj.org/article/fca7dcb5df5c4ddca2e1448f0336fda0
Autor:
Tomas Lagunas, Stephen P. Plassmeyer, Anthony D. Fischer, Ryan Z. Friedman, Michael A. Rieger, Din Selmanovic, Simona Sarafinovska, Yvette K. Sol, Michael J. Kasper, Stuart B. Fass, Alessandra F. Aguilar Lucero, Joon-Yong An, Stephan J. Sanders, Barak A. Cohen, Joseph D. Dougherty
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract The function of regulatory elements is highly dependent on the cellular context, and thus for understanding the function of elements associated with psychiatric diseases these would ideally be studied in neurons in a living brain. Massively
Externí odkaz:
https://doaj.org/article/1be3cfd23894463dbf386a6bfd6edefd
Autor:
Jeffrey L. Hansen, Barak A. Cohen
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-13 (2022)
Abstract Background We and others have suggested that pioneer activity — a transcription factor’s (TF’s) ability to bind and open inaccessible loci — is not a qualitative trait limited to a select class of pioneer TFs. We hypothesize that mos
Externí odkaz:
https://doaj.org/article/87f8dea381a24291ab9020e31dc6946b
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
A large number of RNA binding proteins (RBPs) and miRNAs bind to the 3′ untranslated regions of mRNA, but methods to dissect their function and interactions are lacking. Here the authors introduce post-transcriptional regulatory element sequencing
Externí odkaz:
https://doaj.org/article/860a849ac3354dd6b652646c9de5a8c5
Autor:
Vasavi Sundaram, Mayank N. K. Choudhary, Erica Pehrsson, Xiaoyun Xing, Christopher Fiore, Manishi Pandey, Brett Maricque, Methma Udawatta, Duc Ngo, Yujie Chen, Asia Paguntalan, Tammy Ray, Ava Hughes, Barak A. Cohen, Ting Wang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
The gene-battery model posits transposable elements (TEs) may becis-regulatory elements to control gene expression. Here, mouse-specific TEs are shown as binding sites for multiple collaborating transcription factors in embryonic stem cells, and act
Externí odkaz:
https://doaj.org/article/9182e1481f7b4fb78384a75c96e24065
Autor:
Michael A. White, Jamie C. Kwasnieski, Connie A. Myers, Susan Q. Shen, Joseph C. Corbo, Barak A. Cohen
Publikováno v:
Cell Reports, Vol 17, Iss 5, Pp 1247-1254 (2016)
Summary: Transcription factors often activate and repress different target genes in the same cell. How activation and repression are encoded by different arrangements of transcription factor binding sites in cis-regulatory elements is poorly understo
Externí odkaz:
https://doaj.org/article/9d9be20800164088a90a64c6f018bb29
Akademický článek
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Autor:
Siqi Zhao, Clarice K. Y. Hong, Connie A. Myers, David M. Granas, Michael A. White, Joseph C. Corbo, Barak A. Cohen
Publikováno v:
Nature Genetics. 55:346-354
Autor:
James L. Shepherdson, Ryan Z. Friedman, Yiqiao Zheng, Chi Sun, Inez Y. Oh, David M. Granas, Barak A. Cohen, Shiming Chen, Michael A. White
Publikováno v:
bioRxiv
Dozens of variants in the photoreceptor-specific transcription factor (TF) CRX are linked with different human blinding diseases that vary in their severity and age of onset. How different variants in a single TF cause a range of pathological phenoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f849484d39c188dd4caee3b346c53c3
https://europepmc.org/articles/PMC10245955/
https://europepmc.org/articles/PMC10245955/