Mis-splicing of Mitotic Regulators Sensitizes SF3B1-Mutated Human HSCs to CHK1 Inhibition.

Autor: Sarchi M; Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, Washington.; Department of Molecular Medicine, University of Pavia, Pavia, Italy., Clough CA; Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, Washington.; Molecular and Cellular Biology Program, University of Washington, Seattle, Washington., Crosse EI; Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington.; Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington., Kim J; Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, Washington., Baquero Galvis LD; Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, Washington.; Molecular and Cellular Biology Program, University of Washington, Seattle, Washington., Aydinyan N; Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, Washington., Wellington R; Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, Washington.; Molecular and Cellular Biology Program, University of Washington, Seattle, Washington., Yang F; Department of Molecular Medicine, University of Pavia, Pavia, Italy., Gallì A; Department of Hematology, IRCCS S. Matteo Hospital Foundation, Pavia, Italy., Creamer JP; Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, Washington., Stewart S; Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, Washington., Bradley RK; Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington.; Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington.; Department of Genome Sciences, University of Washington, Seattle, Washington., Malcovati L; Department of Molecular Medicine, University of Pavia, Pavia, Italy.; Department of Hematology, IRCCS S. Matteo Hospital Foundation, Pavia, Italy., Doulatov S; Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, Washington.; Department of Genome Sciences, University of Washington, Seattle, Washington.; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington.

Publikováno v: Blood cancer discovery [Blood Cancer Discov] 2024 Sep 03; Vol. 5 (5), pp. 353-370.