Výsledky vyhledávání - "Baptiste Guey"

Akademický článek

Inflammasome Deletion Promotes Anti-tumor NK Cell Function in an IL-1/IL-18 Independent Way in Murine Invasive Breast Cancer

Autor: Baptiste Guey, Mélanie Bodnar-Wachtel, Annabelle Drouillard, Anaïs Eberhardt, Manon Pratviel, Nadège Goutagny, Nathalie Bendriss-Vermare, Isabelle Puisieux, Christophe Caux, Thierry Walzer, Virginie Petrilli

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

Inflammasomes are molecular complexes that trigger an inflammatory response upon detection of pathogens or danger signals. Recent studies suggest that they are also involved in cancer progression. However, their roles during tumorigenesis remain poor

Externí odkaz: https://doaj.org/article/d665bebdccb641d2943bbe7a759d749b

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Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stress

Publikováno v: Life Science Alliance
Life Science Alliance, 2023, 6 (4), pp.e202201494. ⟨10.26508/lsa.202201494⟩

International audience; NLRP3 is a pattern recognition receptor with a well-documented role in inducing inflammasome assembly in response to cellular stress. Deregulation of its activity leads to many inflammatory disorders including gouty arthritis,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b709990c74738977d3e066c44624153a
https://doi.org/10.26508/lsa.202201494

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NLRP3 controls ATM activation in response to DNA damage

Autor: Nadege Goutagny, Sylvie Lantuejoul, Sabine Hacot, Yohann Couté, Benedicte F. Py, Elise Ballot, Annabelle Ballesta, Laetitia Gerossier, Virginie Pétrilli, Baptiste Guey, Janet E. Hall, Birke Bartosch, François Ghiringhelli, Julie Gorry, Mélanie Bodnar-Wachtel, Anne-Laure Huber

Publikováno v: bioRxiv
BioRxiv

The DNA damage response (DDR) is essential to preserve genomic integrity and acts as abarrier to cancer. The ATM pathway orchestrates the cellular response to DNA double strandbreaks (DSBs), and its attenuation is frequent during tumorigenesis. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2194518eb798b324f486dfed7f72ab00
https://hal.science/hal-03093041/document

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Structural mechanism of cGAS inhibition by the nucleosome

Autor: Ganesh R, Pathare, Alexiane, Decout, Selene, Glück, Simone, Cavadini, Kristina, Makasheva, Ruud, Hovius, Georg, Kempf, Joscha, Weiss, Zuzanna, Kozicka, Baptiste, Guey, Pauline, Melenec, Beat, Fierz, Nicolas H, Thomä, Andrea, Ablasser

Publikováno v: Nature. 587(7835)

The DNA sensor cyclic GMP-AMP synthase (cGAS) initiates innate immune responses following microbial infection, cellular stress and cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c62a78936391fb06069061638e27bec5
https://pubmed.ncbi.nlm.nih.gov/32911482

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A carrier for cyclic dinucleotides

Autor: Baptiste Guey, Andrea Ablasser

Publikováno v: Nature immunology. 20(11)

Cyclic dinucleotides (CDNs) are potent activators of the innate immune sensor STING. The identification of a CDN importer sheds new light on the regulation of extracellular CDNs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2210526374765203a4dbe5e8aed6689
https://pubmed.ncbi.nlm.nih.gov/31602042

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NFκB is a central regulator of protein quality control in response to protein aggregation stresses via autophagy modulation

Autor: Mathieu Nivon, Claudio Hetz, Julie D. Atkin, Loïc Fort, Emma Richet, Baptiste Guey, Maëlenn Fournier, André Patrick Arrigo, Stéphanie Simon, Carole Kretz-Remy, Pascale Muller

Publikováno v: MBoC
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Molecular Biology of the Cell

NFκB is a master regulator of protein quality control. It helps the cells to survive proteotoxicity by modulating autophagy via up-regulation of BAG3 and HspB8 expression, a molecular mechanism relevant to protein conformational diseases.
Durin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217706fa10a705ee9afd6d37a03d4775
https://doi.org/10.1091/mbc.e15-12-0835

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Corrigendum to 'Toll-like receptor 3 downregulation is an escape mechanism from apoptosis during hepatocarcinogenesis' [J Hepatol 71 (2019) 763–772]

Publikováno v: Journal of Hepatology
Journal of Hepatology, 2020, 72 (3), pp.594. ⟨10.1016/j.jhep.2019.11.001⟩
Journal of Hepatology, Elsevier, 2020, 72 (3), pp.594. ⟨10.1016/j.jhep.2019.11.001⟩

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6e62796e50bab777a2588d2e58325b3
https://doi.org/10.1016/j.jhep.2019.11.001

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Assessing Caspase-1 Activation

Autor: Virginie Pétrilli, Baptiste Guey

Publikováno v: Methods in Molecular Biology ISBN: 9781493935642

The caspase-1 enzymatic activity plays a major role in the innate immune response as it regulates the maturation of two major proinflammatory cytokines, the interleukin-1beta (IL-1β) and IL-18. In this chapter, we describe the technique of Western b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5cf08cb58db71612e8d1a9a9d8be4f57
https://doi.org/10.1007/978-1-4939-3566-6_13

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Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function

Autor: Baptiste Guey, Serge Manié, Virginie Pétrilli, Mélanie Bodnar, Aubry Tardivel

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2014, 111 (48), pp.17254-17259. ⟨10.1073/pnas.1415756111⟩

International audience; Inflammasomes are caspase-1-activating multiprotein complexes. The mouse nucleotide-binding domain and leucine rich repeat pyrin containing 1b (NLRP1b) inflammasome was identified as the sensor of Bacillus anthracis lethal tox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6a50553a8d6240871eb2ee9886fdb1d
https://hal.archives-ouvertes.fr/hal-02376146

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Abstract 2038: A novel role for the NLRP3 inflammasome in lung cancer

Autor: Baptiste Guey, Sabine Hacot, Mélanie Bodnar, Sylvie Lantuejoul, Virginie Pétrilli

Publikováno v: Cancer Research. 75:2038-2038

Although significant advances have been made in the diagnosis and treatment of lung cancer, it remains the most fatal cancer worldwide. This poor outcome is mainly due to the limited curative options available especially for advanced cancer stages. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24cf86417e659ac623eb7dbddfbb1409
https://doi.org/10.1158/1538-7445.am2015-2038

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