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Inhibition of α-glucosidase by flavonoids of Cymbopogon citratus (DC) Stapf.

Autor: Borges PHO; University of Coimbra, Faculty of Pharmacy of University of Coimbra, Coimbra, Portugal., Pedreiro S; University of Coimbra, Faculty of Pharmacy of University of Coimbra, Coimbra, Portugal; LAQV, REQUIMTE, Faculty of Pharmacy, University of Coimbra, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal., Baptista SJ; Center for Nuclear Sciences and Technologies, Instituto Superior Técnico, University of Lisbon, Portugal; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal., Geraldes CFGC; Department of Life Sciences, Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal; Coimbra Chemistry Center, Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal., Batista MT; University of Coimbra, Faculty of Pharmacy of University of Coimbra, Coimbra, Portugal; CIEPQPF, Department of Chemical Engineering, Faculty of Science and Technology, University of Coimbra, 3030-790, Coimbra, Portugal., Silva MMC; University of Coimbra, Faculty of Pharmacy of University of Coimbra, Coimbra, Portugal; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal. Electronic address: msilva@ff.uc.pt., Figueirinha A; University of Coimbra, Faculty of Pharmacy of University of Coimbra, Coimbra, Portugal; LAQV, REQUIMTE, Faculty of Pharmacy, University of Coimbra, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal. Electronic address: amfigueirinha@ff.uc.pt.

Publikováno v: Journal of ethnopharmacology [J Ethnopharmacol] 2021 Nov 15; Vol. 280, pp. 114470. Date of Electronic Publication: 2021 Jul 27.

Understanding the Binding Specificity of G-Protein Coupled Receptors toward G-Proteins and Arrestins: Application to the Dopamine Receptor Family.

Autor: Preto AJ; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Faculty of Medicine, Pólo I, 1st floor, 3004-504 Coimbra, Portugal.; University of Coimbra, Center for Innovative Biomedicine and Biotechnology, Faculty of Medicine, Pólo I, 1st floor, 3004-504 Coimbra, Portugal.; Institute for Interdisciplinary Research, University of Coimbra, Casa Costa Alemão - Pólo II | Rua Dom Francisco de Lemos, 3030-789 Coimbra, Portugal., Barreto CAV; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Faculty of Medicine, Pólo I, 1st floor, 3004-504 Coimbra, Portugal.; University of Coimbra, Center for Innovative Biomedicine and Biotechnology, Faculty of Medicine, Pólo I, 1st floor, 3004-504 Coimbra, Portugal.; Institute for Interdisciplinary Research, University of Coimbra, Casa Costa Alemão - Pólo II | Rua Dom Francisco de Lemos, 3030-789 Coimbra, Portugal., Baptista SJ; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Faculty of Medicine, Pólo I, 1st floor, 3004-504 Coimbra, Portugal.; University of Coimbra, Center for Innovative Biomedicine and Biotechnology, Faculty of Medicine, Pólo I, 1st floor, 3004-504 Coimbra, Portugal.; Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10, ao Km 139,7, 2695-066 Bobadela, Portugal., Almeida JG; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Faculty of Medicine, Pólo I, 1st floor, 3004-504 Coimbra, Portugal.; European Bioinformatics Institute EMBL-EBI, Hinxton, Cambridgeshire CB10 1SD, United Kingdom., Lemos A; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Faculty of Medicine, Pólo I, 1st floor, 3004-504 Coimbra, Portugal.; GIGA Cyclotron Research Centre In Vivo Imaging, University of Liège, Bâtiment B30, Allée du 6 Août, 8, 4000 Liège, Belgium., Melo A; REQUIMTE/LAQV, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto, Rua Campo Alegre 687, s/n, 4169-007 Porto, Portugal., Cordeiro MNDS; REQUIMTE/LAQV, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto, Rua Campo Alegre 687, s/n, 4169-007 Porto, Portugal., Kurkcuoglu Z; Bijvoet Center for Biomolecular Research, Faculty of Science - Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands., Melo R; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Faculty of Medicine, Pólo I, 1st floor, 3004-504 Coimbra, Portugal.; University of Coimbra, Center for Innovative Biomedicine and Biotechnology, Faculty of Medicine, Pólo I, 1st floor, 3004-504 Coimbra, Portugal.; Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10, ao Km 139,7, 2695-066 Bobadela, Portugal., Moreira IS; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Faculty of Medicine, Pólo I, 1st floor, 3004-504 Coimbra, Portugal.; University of Coimbra, Center for Innovative Biomedicine and Biotechnology, Faculty of Medicine, Pólo I, 1st floor, 3004-504 Coimbra, Portugal.; Department of Life Sciences, University of Coimbra, Colégio de S. Bento, Calçada Martim de Freitas, 3000-456 Coimbra, Portugal.

Publikováno v: Journal of chemical information and modeling [J Chem Inf Model] 2020 Aug 24; Vol. 60 (8), pp. 3969-3984. Date of Electronic Publication: 2020 Aug 06.

New BACE1 Chimeric Peptide Inhibitors Selectively Prevent AβPP-β Cleavage Decreasing Amyloid-β Production and Accumulation in Alzheimer's Disease Models.

Autor: Resende R; University of Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), Center for Neuroscience and Cell Biology (CNC), Coimbra, Portugal.; University of Coimbra, Institute for Interdisciplinary Research (IIIUC), Coimbra, Portugal., Ferreira-Marques M; University of Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), Center for Neuroscience and Cell Biology (CNC), Coimbra, Portugal.; University of Coimbra, Faculty of Pharmacy, Laboratory of Pharmacology, Coimbra, Portugal., Moreira P; University of Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), Center for Neuroscience and Cell Biology (CNC), Coimbra, Portugal.; University of Coimbra, Faculty of Pharmacy, Laboratory of Pharmacology, Coimbra, Portugal., Coimbra JRM; University of Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), Center for Neuroscience and Cell Biology (CNC), Coimbra, Portugal.; University of Coimbra, Faculty of Pharmacy, Laboratory of Pharmaceutical Chemistry, Coimbra, Portugal., Baptista SJ; University of Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), Center for Neuroscience and Cell Biology (CNC), Coimbra, Portugal.; Chem4Pharma, Coimbra, Portugal., Isidoro C; Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale 'A. Avogadro', Novara, Italy., Salvador JAR; University of Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), Center for Neuroscience and Cell Biology (CNC), Coimbra, Portugal.; University of Coimbra, Faculty of Pharmacy, Laboratory of Pharmaceutical Chemistry, Coimbra, Portugal., Dinis TCP; University of Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), Center for Neuroscience and Cell Biology (CNC), Coimbra, Portugal.; University of Coimbra, Faculty of Pharmacy, Laboratory of Biochemistry and Biology, Coimbra, Portugal., Pereira CF; University of Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), Center for Neuroscience and Cell Biology (CNC), Coimbra, Portugal.; University of Coimbra, Faculty of Medicine, Institute of Biochemistry, Coimbra, Portugal., Santos AE; University of Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), Center for Neuroscience and Cell Biology (CNC), Coimbra, Portugal.; University of Coimbra, Faculty of Pharmacy, Laboratory of Biochemistry and Biology, Coimbra, Portugal.

Publikováno v: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2020; Vol. 76 (4), pp. 1317-1337.

Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment.

Autor: Coimbra JRM; Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra Coimbra, Portugal.; Center for Neuroscience and Cell Biology, University of Coimbra Coimbra, Portugal., Marques DFF; Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra Coimbra, Portugal.; Center for Neuroscience and Cell Biology, University of Coimbra Coimbra, Portugal., Baptista SJ; Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra Coimbra, Portugal.; Center for Neuroscience and Cell Biology, University of Coimbra Coimbra, Portugal.; Chem4Pharma, Edifício IPN Incubadora Coimbra, Portugal., Pereira CMF; Center for Neuroscience and Cell Biology, University of Coimbra Coimbra, Portugal.; Faculty of Medicine, University of Coimbra Coimbra, Portugal., Moreira PI; Center for Neuroscience and Cell Biology, University of Coimbra Coimbra, Portugal.; Laboratory of Physiology, Faculty of Medicine, University of Coimbra Coimbra, Portugal., Dinis TCP; Center for Neuroscience and Cell Biology, University of Coimbra Coimbra, Portugal.; Laboratory of Biochemistry, Faculty of Pharmacy, University of Coimbra Coimbra, Portugal., Santos AE; Center for Neuroscience and Cell Biology, University of Coimbra Coimbra, Portugal.; Laboratory of Biochemistry, Faculty of Pharmacy, University of Coimbra Coimbra, Portugal., Salvador JAR; Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra Coimbra, Portugal.; Center for Neuroscience and Cell Biology, University of Coimbra Coimbra, Portugal.

Publikováno v: Frontiers in chemistry [Front Chem] 2018 May 24; Vol. 6, pp. 178. Date of Electronic Publication: 2018 May 24 (Print Publication: 2018).