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Design and Synthesis of Xanthone Analogues Conjugated with Aza‐aromatic Substituents as Promising G‐Quadruplex Stabilizing Ligands and their Selective Cancer Cell Cytotoxic Action

Autor: Soma Roy, Nirmal Chakraborty, Bappa Maiti, Kalappa Muniyappa, Santanu Bhattacharya

Publikováno v: ChemBioChem. 24

We have examined the stabilization of higher order non-canonical G-quadruplex (G4) DNA structures formed by the G-rich sequences in the promoter region of oncogenes by newly synthesized, novel nitrogen-containing aromatics conjugated to xanthone moie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4a60fee2837576b05ef5116bd5e509
https://doi.org/10.1002/cbic.202200609

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Antibody-Conjugated Vitamin E-Derived Liposomes for Targeted Gene Transfer

Autor: Santanu Bhattacharya, Anjali A. Karande, Saha P, Mohini Kamra, Bappa Maiti

Publikováno v: ACS Applied Bio Materials. 3:8375-8385

Construction of a vitamin E-based liposomal biomaterial and its ability to deliver therapeutic genes selectively across liver cancer cells are demonstrated herein. In humans, liver regulates the levels of α-tocopherol, i.e., vitamin E, and hepatic c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73744a962ad4c719a2d0d1f7a841663e
https://doi.org/10.1021/acsabm.0c00656

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Engaging Dynamic Surfactant Assemblies in Improving Metal Ion Sensitivity of a 1,4,7-Triazacyclononane-Based Receptor: Differential Optical Response for Cysteine and Histidine

Autor: Santanu Bhattacharya, Nilanjan Dey, Bappa Maiti

Publikováno v: ACS applied bio materials. 2(6)

Self-assembly as well as metal ion binding property of an amphiphilic, dansylated 1,4,7-triazacyclononane (TACN) probe have been investigated in the presence of various surfactant assemblies in aqueous media. As expected, the receptor molecule shows

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a02ccce8524702c61f2f996ea74dbe
https://pubmed.ncbi.nlm.nih.gov/35030729

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Novel α-tocopherol-ferrocene conjugates for the specific delivery of transgenes in liver cancer cells under high serum conditions

Autor: Santanu Bhattacharya, Bappa Maiti, Anjali A. Karande, Rahmat Asfiya, Mohini Kamra

Publikováno v: Biomaterials science. 9(22)

The delivery of therapeutic genes to a specific organ has drawn significant research attention. Among the pool of various delivery vectors, cationic liposomes (non-viral) are potential candidates for delivering therapeutic genes due to their low immu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6cd7b91b809101239525ffb2df7358
https://pubmed.ncbi.nlm.nih.gov/34676384

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Transfection efficiencies of α-tocopherylated cationic gemini lipids with hydroxyethyl bearing headgroups under high serum conditions

Autor: Mohini Kamra, Anjali A. Karande, Bappa Maiti, Santanu Bhattacharya

Publikováno v: Organic & Biomolecular Chemistry. 16:1983-1993

Herein, five new α-tocopheryl cationic gemini lipids with hydroxyethyl bearing headgroups (THnS, n = 4, 5, 6, 8, 12) have been synthesized for efficient plasmid DNA (pDNA) delivery into cancer cells. Among these gemini lipid formulations, the lipid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71408cf7f6c5cf0fa5da3865826aa62
https://doi.org/10.1039/c7ob02835k

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Palladium-induced transformation of nematic liquid crystals to robust metallogel comprising self-assembled nanowires

Autor: Santanu Bhattacharya, Bappa Maiti, Subham Bhattacharjee

Publikováno v: Chemical communications (Cambridge, England). 55(84)

The formation of a nematic liquid-crystalline phase in the bulk along with gelation of a novel asymmetric bolaamphiphilic NDI scaffold has been demonstrated. Further, a discrete metal NDI complex that is capable of forming a robust metallogel through

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8248f16f81fe2cad6ad5e8f2d9b5c0fc
https://pubmed.ncbi.nlm.nih.gov/31580338

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Tumor Chemosensitization through Oncogene Knockdown Mediated by Unique α-Tocopherylated Cationic Geminis

Autor: Anjali A. Karande, Akanksha Dixit, Bappa Maiti, Mohini Kamra, Santanu Bhattacharya

Publikováno v: Biomacromolecules. 20(4)

Herein, siRNA transfection efficiency of a unique set of alpha-tocopherylated gemini lipids has been established in vitro and in vivo. High efficacy of oncogene silencing achieved using the biomacromolecular assembly, formed from siRNA complexes of c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b297bdfc364dabcc220b48f1a7e202
https://pubmed.ncbi.nlm.nih.gov/30908014

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Correction: Transfection efficiencies of α-tocopherylated cationic gemini lipids with hydroxyethyl bearing headgroups under high serum conditions

Autor: Bappa Maiti, Mohini Kamra, Anjali A. Karande, Santanu Bhattacharya

Publikováno v: Organicbiomolecular chemistry. 17(8)

Correction for ‘Transfection efficiencies of α-tocopherylated cationic gemini lipids with hydroxyethyl bearing headgroups under high serum conditions’ by Bappa Maiti et al., Org. Biomol. Chem., 2018, 16, 1983–1993.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f02a99ad1eb1f4e893ff3a59c175da36
https://pubmed.ncbi.nlm.nih.gov/29498723

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