Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Baozheng Li"'
Publikováno v:
Human Gene Therapy Methods. 27:143-149
We have described the development of capsid-modified next-generation AAV vectors for both AAV2 and AAV3 serotypes, in which specific surface-exposed tyrosine (Y), serine (S), threonine (T), and lysine (K) residues on viral capsids were modified to ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016f875319a2da2f377dc8d8e82e6dfd
https://doi.org/10.1089/hgtb.2016.054
https://doi.org/10.1089/hgtb.2016.054
Autor:
Changquan Ling, Xiao Xiao, Thomas B. Lentz, Chen Ling, Binbin Cheng, George Aslanidi, Baozheng Li, R. Jude Samulski, Giridhara R. Jayandharan, Yuan Wang, Yuan Lu, Wenqin Ma, Arun Srivastava, Lina Wang, Nicholas Muzyczka
Publikováno v:
Journal of molecular and genetic medicine : an international journal of biomedical research. 9(3)
Chen Ling1,2, Yuan Wang1-3, Yuan Lu4, Lina Wang1-3, Giridhara R Jayandharan5, George V Aslanidi1,2, Baozheng Li1,2, Binbin Cheng1,3, Wenqin Ma1,2, Thomas Lentz6, Changquan Ling3, Xiao Xiao6,7, R Jude Samulski6, Nicholas Muzyczka2,8,9 and Arun Srivast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f2aee3fb4cefe22ab28d6055d36527
https://pubmed.ncbi.nlm.nih.gov/26949410
https://pubmed.ncbi.nlm.nih.gov/26949410
Publikováno v:
Human Gene Therapy. 22:633-640
We have recently shown that co-administration of conventional single-stranded adeno-associated virus 2 (ssAAV2) vectors with self-complementary (sc) AAV2-protein phosphatase 5 (PP5) vectors leads to a significant increase in the transduction efficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e74ccc964119f29cc48f9216b861d11
https://doi.org/10.1089/hum.2010.243
https://doi.org/10.1089/hum.2010.243
Autor:
Seok-Hong Min, Alfred S. Lewin, Li Zhong, Antonette Bennett, Hilda Petrs-Silva, William W. Hauswirth, Giridhara R. Jayandharan, Mavis Agbandje-McKenna, Jijing Pang, Andy W. Neeley, Arun Srivastava, Astra Dinculescu, Qiuhong Li, Wen-Tao Deng, Lakshmanan Govindasamy, Baozheng Li, Vince A. Chiodo
Publikováno v:
Molecular Therapy. 19(2):293-301
Vectors based on adeno-associated virus serotype 2 (AAV2) have been used extensively in many gene-delivery applications, including several successful clinical trials for one type of Leber congenital amaurosis in the retina. Many studies have focused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e362f61cf1300110c40e5ed8b83cda7
Autor:
Li Zhong, Roland W. Herzog, Baozheng Li, Giridhara R. Jayandharan, Mengxin Li, Brandon K. Sack, Arun Srivastava, Angela Rivers
Publikováno v:
Human Gene Therapy. 21:271-283
Our studies have shown that coinjection of conventional single-stranded adeno-associated virus 2 (ssAAV2) vectors carrying the enhanced green fluorescent protein (EGFP) gene with self-complementary (sc) AAV2-T cell protein tyrosine phosphatase (TC-PT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf5ffbc1a520bf91d3f78439dcd4c69
https://doi.org/10.1089/hum.2009.100
https://doi.org/10.1089/hum.2009.100
Autor:
Li Zhong, Nicholas Muzyczka, Sergei Zolotukhin, Lakshmanan Govindasamy, Giridhararao Jayandharan, Kirsten A. Weigel-Van Aken, Roland W. Herzog, Cathryn Mah, Baozheng Li, Arun Srivastava, Mavis Agbandje-McKenna, Jacqueline A. Hobbs
Publikováno v:
Virology. 381(2):194-202
We have documented that epidermal growth factor receptor protein tyrosine kinase (EGFR-PTK) signaling negatively affects intracellular trafficking and transduction efficiency of recombinant adeno-associated virus 2 (AAV2) vectors. Specifically, inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77fa4f0cbae3ffe4dd52c33fe67a39e0
Autor:
Baozheng Li, Zongchao Han, Arun Srivastava, Li Zhong, Kenneth H. Warrington, Wenqin Ma, Kirsten A. Weigel-Kelley, Weihong Zhao, Jianqing Wu
Publikováno v:
Human Gene Therapy. 18:171-182
Self-complementary adeno-associated viral (scAAV) vectors bypass the requirement for viral second-strand DNA synthesis, but the packaging capacity of these vectors ( approximately 2.4 kb) is significantly smaller than that of conventional AAV vectors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c2f0df9cb8b586dfb2bd7369d67ab6
https://doi.org/10.1089/hum.2006.088
https://doi.org/10.1089/hum.2006.088
Autor:
Arun Srivastava, Baozheng Li, Lin Ya Huang, Wenqin Ma, Mavis Agbandje-McKenna, George Aslanidi, Kim Van Vliet, Chen Ling
Publikováno v:
Human gene therapy methods. 26(6)
The ubiquitin-proteasome pathway plays a critical role in the intracellular trafficking of recombinant adeno-associated virus 2 (AAV2) vectors, which negatively impacts the transduction efficiency of these vectors. Because ubiquitination occurs on ly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01c1494b369044804f657c7876c0534
https://pubmed.ncbi.nlm.nih.gov/26421998
https://pubmed.ncbi.nlm.nih.gov/26421998
Autor:
Xiaomiao Li, Mervin C. Yoder, Baozheng Li, Arun Srivastava, Daniela Bischof, Li Zhong, Kenneth H. Warrington, Irene Zolotukhin, Keyun Qing, Njeri Maina, Weihong Zhao, Yanjun Li, Weiming Li, William B. Slayton, Jianqing Wu, Kirsten A. Weigel-Kelley
Publikováno v:
Human Gene Therapy. 17:321-333
Conflicting data exist on hematopoietic cell transduction by AAV serotype 2 (AAV2) vectors, and additional AAV serotype vectors have not been evaluated for their efficacy in hematopoietic stem/progenitor cell transduction. We evaluated the efficacy o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2196b2d600596b75a23e90c7c582dde9
https://doi.org/10.1089/hum.2006.17.321
https://doi.org/10.1089/hum.2006.17.321
Publikováno v:
Molecular Therapy. 24:S39-S40
There is little doubt that AAV did not evolve for the purposes of delivery of therapeutic genes. The use of first generation AAV vectors, albeit successful, is unlikely to reach its full potential. We have described the development of capsid-modified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01234bbc62c16ba3f73ed77190d37b78
https://doi.org/10.1016/s1525-0016(16)32900-8
https://doi.org/10.1016/s1525-0016(16)32900-8