Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Baoxue Ge"'
Autor:
Cheng Peng, Yuanna Cheng, Mingtong Ma, Qiu Chen, Yongjia Duan, Shanshan Liu, Hongyu Cheng, Hua Yang, Jingping Huang, Wenyi Bu, Chenyue Shi, Xiangyang Wu, Jianxia Chen, Ruijuan Zheng, Zhonghua Liu, Zhe Ji, Jie Wang, Xiaochen Huang, Peng Wang, Wei Sha, Baoxue Ge, Lin Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Antimicrobial peptides (AMPs), ancient scavengers of bacteria, are very poorly induced in macrophages infected by Mycobacterium tuberculosis (M. tuberculosis), but the underlying mechanism remains unknown. Here, we report that L-alanine inte
Externí odkaz:
https://doaj.org/article/5dbb15f4b25c4c02bc398d5759c51f5b
Autor:
Mingtong Ma, Yongjia Duan, Cheng Peng, You Wu, Xinning Zhang, Boran Chang, Fei Wang, Hua Yang, Ruijuan Zheng, Hongyu Cheng, Yuanna Cheng, Yifan He, Jingping Huang, Jinming Lei, Hanyu Ma, Liru Li, Jie Wang, Xiaochen Huang, Fen Tang, Jun Liu, Jinsong Li, Ruoyan Ying, Peng Wang, Wei Sha, Yawei Gao, Lin Wang, Baoxue Ge
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-23 (2024)
Abstract Internal N6-methyladenosine (m6A) modifications are among the most abundant modifications of messenger RNA, playing a critical role in diverse biological and pathological processes. However, the functional role and regulatory mechanism of m6
Externí odkaz:
https://doaj.org/article/f6900fca23b74a44b7907ced60dec6be
Autor:
Gui Qian, Yihua Zhang, Yinan Liu, Manman Li, Bowen Xin, Wenyi Jiang, Wendong Han, Yu Wang, Xian Tang, Liuyan Li, Lingyan Zhu, Tao Sun, Bo Yan, Yongtang Zheng, Jianqing Xu, Baoxue Ge, Zheng Zhang, Dapeng Yan
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112442- (2023)
Summary: Cyclic GMP-AMP synthase (cGAS) recognizes Y-form cDNA of human immunodeficiency virus type 1 (HIV-1) and initiates antiviral immune response through cGAS-stimulator of interferon genes (STING)-TBK1-IRF3-type I interferon (IFN-I) signalingcas
Externí odkaz:
https://doaj.org/article/6730873d437a4b00a6bc176de79674de
Autor:
Youchao Dai, Chuanzhi Zhu, Wei Xiao, Kaisong Huang, Xin Wang, Chenyan Shi, Dachuan Lin, Huihua Zhang, Xiaoqian Liu, Bin Peng, Yi Gao, Cui Hua Liu, Baoxue Ge, Stefan H.E. Kaufmann, Carl G. Feng, Xinchun Chen, Yi Cai
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 8 (2023)
Ferritin, a key regulator of iron homeostasis in macrophages, has been reported to confer host defenses against Mycobacterium tuberculosis (Mtb) infection. Nuclear receptor coactivator 4 (NCOA4) was recently identified as a cargo receptor in ferritin
Externí odkaz:
https://doaj.org/article/3478bdbf22844e8aa84990870d3c58ed
Autor:
Haipeng Liu, Hang Su, Fei Wang, Yifang Dang, Yijiu Ren, Shenyi Yin, Huinan Lu, Hang Zhang, Jun Wu, Zhu Xu, Mengge Zheng, Jiani Gao, Yajuan Cao, Junfang Xu, Li Chen, Xiangyang Wu, Mingtong Ma, Long Xu, Fang Wang, Jianxia Chen, Chunxia Su, Chunyan Wu, Huikang Xie, Jijie Gu, Jianzhong Jeff Xi, Baoxue Ge, Yiyan Fei, Chang Chen
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112275- (2023)
Summary: Enhancing chemosensitivity is one of the largest unmet medical needs in cancer therapy. Cyclic GMP-AMP synthase (cGAS) connects genome instability caused by platinum-based chemotherapeutics to type I interferon (IFN) response. Here, by using
Externí odkaz:
https://doaj.org/article/10d05e06853d4217b7c3ab82cc3ec68e
Autor:
Hua Yang, Fei Wang, Xinya Guo, Feng Liu, Zhonghua Liu, Xiangyang Wu, Mengmeng Zhao, Mingtong Ma, Haipeng Liu, Lianhua Qin, Lin Wang, Tianqi Tang, Wei Sha, Yang Wang, Jianxia Chen, Xiaochen Huang, Jie Wang, Cheng Peng, Ruijuan Zheng, Fen Tang, Lu Zhang, Chunyan Wu, Stefan H. Oehlers, Zhigang Song, Jialei She, Hua Feng, Xunwei Xie, Baoxue Ge
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-18 (2021)
Abstract Pathogenic mycobacteria induce the formation of hypoxic granulomas during latent tuberculosis (TB) infection, in which the immune system contains, but fails to eliminate the mycobacteria. Fatty acid metabolism-related genes are relatively ov
Externí odkaz:
https://doaj.org/article/8926a826463b41a297a8323e451cdda6
Autor:
Lin Wang, Yilong Zhou, Zijuan Chen, Lei Sun, Juehui Wu, Haohao Li, Feng Liu, Fei Wang, Chunfu Yang, Juhao Yang, Qibin Leng, Qingli Zhang, Ajing Xu, Lisong Shen, Jinqiao Sun, Dianqing Wu, Caiyun Fang, Haojie Lu, Dapeng Yan, Baoxue Ge
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Phospholipase C β (PLCβ) exhibits immuno-modulatory functions but its role in antiviral innate responses is unclear. Here, the authors provide evidence that PLCβ2 down regulates enterovirus-induced pro-inflammatory responses via inhibition of TAK1
Externí odkaz:
https://doaj.org/article/61df262c7ea34473b596a6f97d705c8e
Autor:
Ruixue Zhou, Zijuan Chen, Doudou Hao, Yu Wang, Yihua Zhang, Xianfu Yi, Liang-Dong Lyu, Haipeng Liu, Quanming Zou, Yiwei Chu, Baoxue Ge, Dapeng Yan
Publikováno v:
Emerging Microbes and Infections, Vol 8, Iss 1, Pp 734-748 (2019)
ABSTRACTMany pathogens infect hosts through various immune evasion strategies. However, the molecular mechanisms by which pathogen proteins modulate and evade the host immune response remain unclear. Enterohemorrhagic Escherichia coli (EHEC) is a pat
Externí odkaz:
https://doaj.org/article/9ae96192bf31483494a8b7ee9a4bdb45
Autor:
Lianhua Qin, Jie Wang, Junmei Lu, Hua Yang, Ruijuan Zheng, Zhonghua Liu, Xiaochen Huang, Yonghong Feng, Zhongyi Hu, Baoxue Ge
Publikováno v:
BMC Biology, Vol 17, Iss 1, Pp 1-12 (2019)
Abstract Background The emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb), especially those that are multidrug resistant poses a serious threat to global tuberculosis control. However, the mechanism underlying the occurrence of
Externí odkaz:
https://doaj.org/article/526ce3257ef94d60ac55ce6c96e69909
Autor:
Ruijuan Zheng, Zhiqiang Li, Fusheng He, Haipeng Liu, Jianhua Chen, Jiayu Chen, Xuefeng Xie, Juan Zhou, Hao Chen, Xiangyang Wu, Juehui Wu, Boyu Chen, Yahui Liu, Haiyan Cui, Lin Fan, Wei Sha, Yin Liu, Jiqiang Wang, Xiaochen Huang, Linfeng Zhang, Feifan Xu, Jie Wang, Yonghong Feng, Lianhua Qin, Hua Yang, Zhonghua Liu, Zhenglin Cui, Feng Liu, Xinchun Chen, Shaorong Gao, Silong Sun, Yongyong Shi, Baoxue Ge
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Genetic risk loci for tuberculosis (TB) have so far been identified in African and Russian populations. Here, the authors perform a three-stage GWAS for TB in Han Chinese populations and find two risk loci near ESRRB and TGM6 and further demonstrate
Externí odkaz:
https://doaj.org/article/d25f58a54d96443bbd352c706c5d3f44