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Akademický článek

MicroRNA-150-5p inhibits the proliferation and invasion of human larynx epidermiod cancer cells though regulating peptidyl-prolyl cis/trans isomerase

Autor: Hailin Chen, Xuwei Cai, Baowen Du, Jianpiao Cai, Zhengzheng Luo

Publikováno v: Brazilian Journal of Otorhinolaryngology, Vol 89, Iss 3, Pp 383-392 (2023)

Objective: This study aimed to investigate the molecular mechanism of miR-150-5p regulating the malignant biological behavior of Human Epidermoid cancer cell (HEp-2) by targeting peptidyl-prolyl cis/trans isomerase NIMA-Interacting-1 (PIN1). Methods:

Externí odkaz: https://doaj.org/article/a95d7c75e1374e25863e610369332558

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Akademický článek

Isolation and characterization of new phenolic compounds with estrogen biosynthesis-inhibiting and antioxidation activities from Broussonetia papyrifera leaves.

Autor: Chunyan Yang, Fu Li, Baowen Du, Bin Chen, Fei Wang, Mingkui Wang

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e94198 (2014)

Broussonetia papyrifera leaves (BPL) as a traditional Chinese medicine are also used in livestock feed for stimulating reproduction, adipose tissue and muscle development; however, the mechanism of their action is still unknown. Through estrogen bios

Externí odkaz: https://doaj.org/article/c1edc48d0f334efb920a09bc046fa2df

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The protective effects of omarigliptin against interleukin-17-induced mucin secretion in human nasal epithelial cells

Autor: Baowen Du, Chu Yang, Xiaoyan Zhong, Shijie Ye

Publikováno v: Materials Express. 12:660-667

Interleukin (IL)-17 plays an important role in the initiation and development of allergic rhinitis (AR). Omarigliptin, an inhibitor of dipeptidyl peptidase-4 (DPP-4), has been licensed for the treatment of type 2 diabetes mellitus (T2DM). However, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31586953b12b6571ed1d5caa8d29f045
https://doi.org/10.1166/mex.2022.2198

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Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response

Autor: Kaiju Li, Ran Zhou, Yichen Yan, Yaoyao Zhang, Zhidan Li, Wei Fan, Shusen He, Ling Ya Cao, Chuan. Chen, Qingfeng Li, Huiping Yang, ShiKun Lei, Zhen Zhen Zhou, Yuquan Wei, Mengjiao Li, Binwu Ying, Yingfen Liu, Jiufeng Sun, Ping He, Bowen Ke, Eric J. Snijder, Yunzi Luo, Chengdi Wang, Ming Zhang, Xia Xiao, Hongping Wei, Wanqin Zeng, Olli Vapalahti, Yuancun Zhao, Xiuran Zheng, Qingxin Yang, Chang-ling Li, Lev Levanov, Yupeng Li, Liping Wang, Thomas R. Connor, Danrui Wang, Guangwen Lu, Yongmei Jiang, Lifang Zhou, Huayi Liu, Junwei Song, Zhiyong Xu, Han-cheng Wei, Ming-xia Yu, Teemu Smura, Minjin Wang, Xinqiong Li, Lu Yang Cheng, Ke Sun, Ruirui Yang, Li Chen, Ming Pan, Lu Chen, Wei Hong, Mengying Xu, Natacha S. Ogando, Dan Ning Zhang, Jing-wen Lin, Yi Zha, Jia Geng, Wenjie Tan, Jiannan Xu, Chao Tang, Changxiu Yu, Yongzhao Zhou, Baowen Du, Lingyu Jiang, Yiming Zhang, Fei Ye, Weimin Li, Sha-sha Chen, Feng Luo, Suvi Kuivanen

Publikováno v: Cell Host & Microbe
Cell Host & Microbe, 29(3), 489-502.e8

The SARS-CoV-2 virus, the causative agent of COVID-19, is undergoing constant mutation. Here, we utilized an integrative approach combining epidemiology, virus genome sequencing, clinical phenotyping, and experimental validation to locate mutations o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3777682dfe57f93221e7847280c7685e
https://aaltodoc.aalto.fi/handle/123456789/102598

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Enhancer RNAs Mediate Estrogen-Induced Decommissioning of Selective Enhancers by Recruiting Erα and Its Cofactor

Autor: Yanming Wu, Juyeong Hong, Michael G. Rosenfeld, Yiji Liao, Baowen Du, Kexin Xu, Zhijie Liu, Ji Hoon Lee, Richard De La Rosa, Wei Li, Teng Fei, Yuliang Tan, Chen-Lin Hsieh, Mei Yang, Zhao Zhang, Wenbo Li, Tao Hong, Mingjun Bi

Publikováno v: SSRN Electronic Journal.

Although accumulating evidence has demonstrated that individual enhancer RNAs (eRNAs) exert critical biological functions rather than being passive transcriptional byproducts, the mechanisms of action of these non-coding transcripts remain obscure an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85c6f2fec8cb089b4730a10ea58f1ab7
https://doi.org/10.2139/ssrn.3497740

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Enhancer RNAs Mediate Estrogen-Induced Decommissioning of Selective Enhancers by Recruiting ERα and Its Cofactor

Autor: Mei Yang, Ji Hoon Lee, Wenbo Li, Jessica Scheirer, Yuliang Tan, Michael G. Rosenfeld, Tao Hong, Mingjun Bi, Richard De La Rosa, Zhao Zhang, Yiji Liao, Wei Li, Chen-Lin Hsieh, Teng Fei, Kexin Xu, Zhijie Liu, Baowen Du, Juyeong Hong, Yanming Wu

Publikováno v: Cell reports

SUMMARY The function of enhancer RNAs (eRNAs) in transcriptional regulation remains obscure. By analyzing the genome-wide nascent transcript profiles in breast cancer cells, we identify a special group of eRNAs that are essential for estrogen-induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ab099602cb9d0c4c3a80357933f78b
https://doi.org/10.1016/j.celrep.2020.107803

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Umbilical cord blood mesenchymal stem cells co‐modified by TERT and BDNF: A novel neuroprotective therapy for neonatal hypoxic‐ischemic brain damage

Autor: Baowen Du, Fengyan Zhao, Dezhi Mu, Yi Qu, Haiting Liu

Publikováno v: International Journal of Developmental Neuroscience. 38:147-154

Hypoxic-ischemic brain damage (HIBD), a leading cause of perinatal disability and death, has limited therapeutic options. Stem cell therapy has been demonstrated as a potential novel therapy for neurological disorders. Compared with other types of st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b8975d43065cd6c2f4f76e6bd11b80
https://doi.org/10.1016/j.ijdevneu.2014.06.014

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