Cell‐to‐cell and type‐to‐type heterogeneity of signaling networks: insights from the crowd

Autor: Attila Gabor, Marco Tognetti, Alice Driessen, Jovan Tanevski, Baosen Guo, Wencai Cao, He Shen, Thomas Yu, Verena Chung, Single Cell Signaling in Breast Cancer DREAM Consortium members, Bernd Bodenmiller, Julio Saez‐Rodriguez, Augustinas Prusokas, Alidivinas Prusokas, Renata Retkute, Anand Rajasekar, Karthik Raman, Malvika Sudhakar, Raghunathan Rengaswamy, Edward S.C. Shih, Min‐jeong Kim, Changje Cho, Dohyang Kim, Hyeju Oh, Jinseub Hwang, Kim Jongtae, Yeongeun Nam, Sanghoo Yoon, Taeyong Kwon, Kyeongjun Lee, Sarika Chaudhary, Nehal Sharma, Shreya Bande, Gao Gao fan zhu Cankut Cubuk, Pelin Gundogdu, Joaquin Dopazo, Kinza Rian, Carlos Loucera, Matias M Falco, Martin Garrido‐Rodriguez, Maria Peña‐Chilet, Huiyuan Chen, Gabor Turu, Laszlo Hunyadi, Adam Misak, Lisheng Zhou, Xiaoqing Jiang, Pieta Zhang, Aakansha Rai, Rintu Kutum, Sadhna Rana, Rajgopal Srinivasan, Swatantra Pradhan, James Li, Vladimir Bajic, Christophe Van Neste, Didier Barradas‐bautista, Somayah Abdullah Albarade, Igor Nikolskiy, Musalula Sinkala, Duc Tran, Hung Nguyen, Tin Nguyen, Alexander Wu, Benjamin DeMeo, Brian Hie, Rohit Singh, Jiwei Liu, Xueer Chen, Leonor Saiz, Jose M. G Vilar, Peng Qiu, Akash Gosain, Anjali Dhall, Dinesh Bajaj, Harpreet Kaur, Krishna Bagaria, Mayank Chauhan, Neelam Sharma, Gajendra Raghava, Sumeet Patiyal, Jianye Hao, Jiajie Peng, Shangyi Ning, Yi Ma, Zhongyu Wei, Atte Aalto, Jorge Goncalves, Laurent Mombaerts, Xinnan Dai, Jie Zheng, Piyushkumar Mundra, Fan Xu, Jie Wang, Krishna Kant Singh, Mingyu Lee

Publikováno v: Molecular Systems Biology, Vol 17, Iss 10, Pp 1-16 (2021)

Abstract Recent technological developments allow us to measure the status of dozens of proteins in individual cells. This opens the way to understand the heterogeneity of complex multi‐signaling networks across cells and cell types, with important

Externí odkaz: https://doaj.org/article/bcd5b154a6e240949fe3c514a36f69b2

BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer

Autor: Shao Zhimin, Di Zhu, Jinpeng Pei, Yi Xiao, Qiaofeng Liu, Xiaoshuang Wang, Ker Yu, Rina Rosin-Arbesfeld, Tengfei Xiao, Yu-Xiong Feng, Ying Shi, Chenglong Liu, Yang Zhou, Mei Feng, Baosen Guo, Danyang Liu, Yi-Zhou Jiang, Mengxuan Yang

Publikováno v: Oncogene. 40:2982-2997

Treatment of patients with triple-negative breast cancer (TNBC) has been challenging due to a lack of well-defined molecular targets. The Wnt/β-catenin pathway is known to be activated in many TNBC patients and BCL9 and BCL9L are important transcrip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25bedd758ff17619db2b71b27fdefa93
https://doi.org/10.1038/s41388-021-01756-y

A Reference Feature based method for Quantification and Identification of LC-MS based untargeted metabolomics

Autor: Binghang Liu, Zhenyu Li, Wang Yalan, lei feng, Fengji Tan, Luan Enhui, baosen guo, Long Qiaoyun, Cheng Ken, Hancheng Zheng, Li Wei, Song Jiaping, Li Dehua, xiaoyi yi

Batch inconsistency is a major problem when applying LC-MS based untargeted metabolomics in real-time analysis situation such as clinical diagnosis or health monitoring. And inefficiency of collecting MS2 is a major problem for metabolite identificat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43740956752d9b168f21bd0f79e6e80f

Long noncoding RNA CCDC144NL-AS1 knockdown induces naïve-like state conversion of human pluripotent stem cells

Autor: Yueqiang Song, Yingying Wang, Zhihua Shao, Siguang Li, Zengrong Xiao, Xuehu Gao, Xi Zhang, Yalei Li, Haijun Lin, Jinjun Yu, Xuekun Li, Yuping Luo, Baosen Guo

Publikováno v: Stem Cell Research & Therapy
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-22 (2019)

Background Human naïve pluripotency state cells can be derived from direct isolation of inner cell mass or primed-to-naïve resetting of human embryonic stem cells (hESCs) through different combinations of transcription factors, small molecular inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19829a7122f447d18e7df177d5ae52c2
http://europepmc.org/articles/PMC6664583

Additional file 4: of Long noncoding RNA CCDC144NL-AS1 knockdown induces naĂŻve-like state conversion of human pluripotent stem cells

Autor: Yingying Wang, Baosen Guo, Zengrong Xiao, Haijun Lin, Zhang, Xi, Yueqiang Song, Yalei Li, Xuehu Gao, Jinjun Yu, Zhihua Shao, Xuekun Li, Yuping Luo, Siguang Li

Figure S1. Functional categories of genes from three human PSC-specific modules enriched by WGCNA. a WGCNA dendogram indicating expression of different gene modules in all 55 samples. b-d Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd687de03cfa7b09750ec2b6c743d4e