Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Baomin Xin"'
Autor:
Baomin Xin, Timothy V Olah, Eric Shields, Dieter M. Drexler, Steven A. Stryker, Donald G. Robertson, Michael D. Reily, David M. Nelson, Petia Shipkova, Joanna J. Zheng, Kimberly Snow
Publikováno v:
Analytical Biochemistry. 503:71-78
The growing field of biomarker bioanalysis by liquid chromatography mass spectrometry (LC-MS) is challenged with the selection of suitable matrices to construct relevant and valid calibration curves resulting in not only precise but also accurate dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c29ddabfd98a55ae905403847f9540
https://doi.org/10.1016/j.ab.2016.03.011
https://doi.org/10.1016/j.ab.2016.03.011
Autor:
Atsu Apedo, Pancras C. Wong, Olafur S. Gudmundsson, Nathalie Toussaint, Yiming Wu, Timothy W. Harper, Silvi A. Chacko, Leon M. Smith, Baomin Xin, Dietmar A. Seiffert, Steven Sheriff, Ruth R. Wexler, William R. Ewing, Jeffrery M. Bozarth, Mimi L. Quan, Zhen Lou, Earl J. Crain, Brad D. Maxwell, Joanna J. Zheng, Arvind Mathur, Paul Stetsko, Joseph E. Myers, Donald J. P. Pinto, Michael J. Orwat, Karen A. Rossi, Patrick Y.S. Lam, Xiaoping Hou, Joseph M. Luettgen, Huiping Zhang
Publikováno v:
Journal of medicinal chemistry. 60(23)
Factor XIa (FXIa) is a blood coagulation enzyme that is involved in the amplification of thrombin generation. Mounting evidence suggests that direct inhibition of FXIa can block pathologic thrombus formation while preserving normal hemostasis. Precli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::650dd41ad8db2c8388fa2722b2f90057
https://pubmed.ncbi.nlm.nih.gov/29077405
https://pubmed.ncbi.nlm.nih.gov/29077405
Autor:
Baomin Xin, Timothy V Olah, Hongwei Zhang, Adrienne A. Tymiak, Ashok Dongre, Wendy L. Trigona, Qing Xiao
Publikováno v:
Rapid Communications in Mass Spectrometry. 28:1535-1543
RATIONALE Liquid chromatography/tandem mass spectrometry (LC/MS/MS) assays are increasingly being used for absolute quantitation of proteins due to high specificity and low cost. However, the major challenge for the LC/MS method is insufficient sensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1027d913bdda89c498efd16089f6a5f
https://doi.org/10.1002/rcm.6928
https://doi.org/10.1002/rcm.6928
Publikováno v:
Bioanalysis. 6:859-879
As more protein therapeutics enter the drug-discovery pipeline, the traditional ligand-binding assay (LBA) faces additional challenges to meet the rapid and diverse bioanalytical needs in the early drug-discovery stage. The high specificity and sensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb706666e2ab74a0756f75b5d6928e7a
https://doi.org/10.4155/bio.14.36
https://doi.org/10.4155/bio.14.36
Autor:
Qian Xiang, Dietmar A. Seiffert, Wu Yang, Tianan Fang, Joseph E. Myers, Joanne M. Smallheer, Patrick Y.S. Lam, Jeon Yoon T, Zhen Lou, Joanna Zheng, Joseph M. Luettgen, Jeffrey M. Bozarth, Steven Sheriff, Yufeng Wang, William R. Ewing, Zilun Hu, Indawati De Lucca, Donald J. P. Pinto, Michael J. Orwat, James R. Corte, Charles G. Clark, Karen A. Rossi, Alan R. Rendina, Timothy W. Harper, Ruth R. Wexler, David S. Nirschl, Baomin Xin, Yiming Wu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:126604
This manuscript describes the discovery of a series of macrocyclic inhibitors of FXIa with oral bioavailability. Assisted by structure based drug design and ligand bound X-ray crystal structures, the group linking the P1 moiety to the macrocyclic cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2efb9337fd87b82e6dbe509f35d0ce6
https://doi.org/10.1016/j.bmcl.2019.08.008
https://doi.org/10.1016/j.bmcl.2019.08.008
Publikováno v:
Rapid Communications in Mass Spectrometry. 25:3427-3435
Highly sensitive liquid chromatography/tandem mass spectrometry (LC/MS/MS)-based methods have been developed and implemented for the quantitative determination of a number of peptides under evaluation in our Glucagon-Like Peptide-1 (GLP-1) discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2d9139c2b874129ee4b604ec21e6838
https://doi.org/10.1002/rcm.5241
https://doi.org/10.1002/rcm.5241
Autor:
Joseph M. Luettgen, Scott J. Grossman, Ruth R. Wexler, Robert M. Knabb, Pancras C. Wong, Donglu Zhang, Patrick Y.S. Lam, Kan He, Bing He, Donald J. P. Pinto, James E. Grace, Baomin Xin
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 36:129-139
Apixaban is a potent, highly selective, reversible, oral, direct factor Xa (fXa) inhibitor in development for thrombosis prevention and treatment. The preclinical pharmacokinetic (PK) attributes of apixaban feature small volume of distribution (Vd),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aee5a2433c87133d73a8543d56dcbb0
https://doi.org/10.1007/s13318-011-0037-x
https://doi.org/10.1007/s13318-011-0037-x
Publikováno v:
Bioanalysis. 3:863-871
Background: Orbitrap™ mass spectrometry has made significant impacts in the qualitative field of mass spectrometry, and it can be a potentially powerful quantitative technique. Because the Orbitrap is a relatively new platform, our understanding of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a2abcb4f4e56534c8ecd0989d18859
https://doi.org/10.4155/bio.11.37
https://doi.org/10.4155/bio.11.37
Autor:
Kan He, Stephen Johnson, Saeho Chong, Timothy W. Harper, Gang Luo, Baomin Xin, Mei-Mann Hsueh, Hong Cai, Joanna Zheng
Publikováno v:
Drug Metabolism and Disposition. 38:422-430
Evaluating biliary excretion, a major elimination pathway for many compounds, is important in drug discovery. The bile duct-cannulated (BDC) rat model is commonly used to determine the percentage of dose excreted as intact parent into bile. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c43850231fd3652d3ba65b0020e0a457
https://doi.org/10.1124/dmd.108.026260
https://doi.org/10.1124/dmd.108.026260
Publikováno v:
Rapid Communications in Mass Spectrometry. 23:3457-3464
QuickQuan is an integrated software package for Thermo Scientific triple quadrupole mass spectrometers that allows users to automate routine operations ranging from method development to data processing. QuickQuan automated optimization of compound-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7189ef0bc1614ea7cda4926e1425088
https://doi.org/10.1002/rcm.4264
https://doi.org/10.1002/rcm.4264