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Akademický článek

Reducing brain TACE activity improves neuroinflammation and cardiac function in heart failure rats

Autor: Yang Yu, Baojian Xue, Nafis Md Irfan, Terry Beltz, Robert M Weiss, Alan Kim Johnson, Robert B Felder, Shun-Guang Wei

Publikováno v: Frontiers in Physiology, Vol 13 (2022)

Tumor necrosis factor (TNF)-α converting enzyme (TACE) is a key metalloprotease mediating ectodomain shedding of a variety of inflammatory mediators, substrates, and growth factors. We previously reported that TACE-mediated production of TNF-α in t

Externí odkaz: https://doaj.org/article/b5f5e1ecb4db434484b9be125d21515f

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Akademický článek

Voluntary Exercise Prevents Hypertensive Response Sensitization Induced by Angiotensin II

Autor: Baojian Xue, Jun-Ling Cui, Fang Guo, Terry G. Beltz, Zi-Gang Zhao, Geng-Shen Zhang, Alan Kim Johnson

Publikováno v: Frontiers in Neuroscience, Vol 16 (2022)

Exercise training has profound effects on the renin-angiotensin system, inflammatory cytokines and oxidative stress, all of which affect autonomic nervous system activity and regulate blood pressure (BP) in both physiological and pathophysiological s

Externí odkaz: https://doaj.org/article/58d9f04ba91d46b38f3eac864dff9461

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Akademický článek

Neuroanatomical organization and functional roles of PVN MC4R pathways in physiological and behavioral regulations

Autor: Uday Singh, Jingwei Jiang, Kenji Saito, Brandon A. Toth, Jacob E. Dickey, Samuel R. Rodeghiero, Yue Deng, Guorui Deng, Baojian Xue, Zhiyong Zhu, Leonid V. Zingman, Joel C. Geerling, Huxing Cui

Publikováno v: Molecular Metabolism, Vol 55, Iss , Pp 101401- (2022)

Objective: The paraventricular nucleus of hypothalamus (PVN), an integrative center in the brain, orchestrates a wide range of physiological and behavioral responses. While the PVN melanocortin 4 receptor (MC4R) signaling (PVNMC4R+) is involved in fe

Externí odkaz: https://doaj.org/article/f23e353353074ec18fb72ccfd9f75768

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Akademický článek

Loss of the Protective Effect of Estrogen Contributes to Maternal Gestational Hypertension‐Induced Hypertensive Response Sensitization Elicited by Postweaning High‐Fat Diet in Female Offspring

Autor: Baojian Xue, Yang Yu, Terry G. Beltz, Fang Guo, Shun‐Guang Wei, Alan Kim Johnson

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 2 (2022)

Background A recent study conducted in male offspring demonstrated that maternal gestational hypertension (MHT) induces hypertensive response sensitization (HTRS) elicited by postweaning high‐fat diet (HFD). In this study, we investigated the sensi

Externí odkaz: https://doaj.org/article/987815985ccd4dd49c068d510919c4c7

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Akademický článek

Maternal Angiotensin II–Induced Hypertension Sensitizes Postweaning High‐Fat Diet–Elicited Hypertensive Response Through Increased Brain Reactivity in Rat Offspring

Autor: Baojian Xue, Yang Yu, Terry G. Beltz, Fang Guo, Robert B. Felder, Shun‐Guang Wei, Alan Kim Johnson

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 18 (2021)

Background Prenatal and postnatal insults can induce a physiological state that leaves offspring later in life vulnerable to subsequent challenges (stressors) eliciting cardiometabolic diseases including hypertension. In this study, we investigated w

Externí odkaz: https://doaj.org/article/6d3cc79e295144ecb23c4aeda9162a4d

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Akademický článek

Interactions of the Brain Renin-Angiotensin-System (RAS) and Inflammation in the Sensitization of Hypertension

Autor: Baojian Xue, Yuping Zhang, Alan Kim Johnson

Publikováno v: Frontiers in Neuroscience, Vol 14 (2020)

Mounting evidence indicates that the renin-angiotensin (RAS) and immune systems interact with one another in the central nervous system (CNS) and that they are importantly involved in the pathogenesis of hypertension. Components comprising the classi

Externí odkaz: https://doaj.org/article/1e5c3a23c6ef438791e94a585a6c5263

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