Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Bao-Ting Zhang"'
Publikováno v:
RNA Biology, Vol 20, Iss 1, Pp 384-397 (2023)
In the past two decades, machine learning (ML) has been extensively adopted in protein-targeted small molecule (SM) discovery. Once trained, ML models could exert their predicting abilities on large volumes of molecules within a short time. However,
Externí odkaz:
https://doaj.org/article/8bf420555e5f4118ad24c77875109cfd
Autor:
Yuanyuan Yu, Luyao Wang, Shuaijian Ni, Dijie Li, Jin Liu, Hang Yin Chu, Ning Zhang, Meiheng Sun, Nanxi Li, Qing Ren, Zhenjian Zhuo, Chuanxin Zhong, Duoli Xie, Yongshu Li, Zong-Kang Zhang, Huarui Zhang, Mei Li, Zhenlin Zhang, Lin Chen, Xiaohua Pan, Weibo Xia, Shu Zhang, Aiping Lu, Bao-Ting Zhang, Ge Zhang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Antibodies targeting sclerostin can ameliorate postmenopausal osteoporosis but present some cardiovascular risk. Here the authors show that the cardiovascular and skeletal effects of sclerostin are mediated by different loops, suggesting ways to pres
Externí odkaz:
https://doaj.org/article/ff38f6e32b034261a6747ac670344b44
Autor:
Hewen Jiang, Zongkang Zhang, Yuanyuan Yu, Hang Yin Chu, Sifan Yu, Shanshan Yao, Ge Zhang, Bao-Ting Zhang
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Dickkopf-1 (DKK1) is a well-characterized Wnt inhibitor and component of the Wnt/β-catenin signaling pathway, whose dysregulation is associated with multiple abnormal pathologies including osteoporosis, Alzheimer’s disease, diabetes, and various c
Externí odkaz:
https://doaj.org/article/d31ac2f6c2ac4bb2a8c1ced9b792a3c3
Autor:
Chao Liang, Jie Li, Cheng Lu, Duoli Xie, Jin Liu, Chuanxin Zhong, Xiaohao Wu, Rongchen Dai, Huarui Zhang, Daogang Guan, Baosheng Guo, Bing He, Fangfei Li, Xiaojuan He, Wandong Zhang, Bao-Ting Zhang, Ge Zhang, Aiping Lu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Leflunomide is used for the treatment of rheumatoid arthritis. Here, the authors show that effectiveness is limited in patients with higher levels of serum c-reactive protein (CRP). Using animal models, they show that higher CRP induces HIF1a express
Externí odkaz:
https://doaj.org/article/efd52d5facbd414982f94122c9661d92
Autor:
Hang Yin Chu, Zihao Chen, Luyao Wang, Zong-Kang Zhang, Xinhuan Tan, Shuangshuang Liu, Bao-Ting Zhang, Aiping Lu, Yuanyuan Yu, Ge Zhang
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Clinical studies in a range of cancers have detected elevated levels of the Wnt antagonist Dickkopf-1 (DKK1) in the serum or tumors of patients, and this was frequently associated with a poor prognosis. Our analysis of DKK1 gene profile using data fr
Externí odkaz:
https://doaj.org/article/d371f27c27c64fddb6638d6bf4223063
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Connective tissue growth factor (CTGF) is a key signaling and regulatory molecule involved in different biological processes, such as cell proliferation, angiogenesis, and wound healing, as well as multiple pathologies, such as tumor development and
Externí odkaz:
https://doaj.org/article/7e20de2e919343a6aec21c4932760d49
Autor:
Zhenjian Zhuo, Youyang Wan, Daogang Guan, Shuaijian Ni, Luyao Wang, Zongkang Zhang, Jin Liu, Chao Liang, Yuanyuan Yu, Aiping Lu, Ge Zhang, Bao‐Ting Zhang
Publikováno v:
Advanced Science, Vol 7, Iss 13, Pp n/a-n/a (2020)
Abstract Several virtual screening models are proposed to screen small molecules only targeting primary miRNAs without selectivity. Few attempts have been made to develop virtual screening strategies for discovering small molecules targeting mature m
Externí odkaz:
https://doaj.org/article/048b07d394874fcbad8e635ae5acfa25
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Osteoporosis is age-related deterioration in bone mass and micro-architecture. Denosumab is a novel human monoclonal antibody for osteoporosis. It is a receptor activator of nuclear factor-κB ligand (RANKL) inhibitor, which binds to and inhibits ost
Externí odkaz:
https://doaj.org/article/4e5ce65c73c94bc090a4f5227e30d827
Autor:
Chao Liang, Songlin Peng, Jie Li, Jun Lu, Daogang Guan, Feng Jiang, Cheng Lu, Fangfei Li, Xiaojuan He, Hailong Zhu, D. W. T. Au, Dazhi Yang, Bao-Ting Zhang, Aiping Lu, Ge Zhang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
BMP promotes bone formation but its efficacy is limited in some patients. Here, the authors show that osteoporosis patients with a poor response to BMP have increased expression of Smurf1, which targets BMP effectors for degradation, and demonstrate
Externí odkaz:
https://doaj.org/article/0b158da3ebda4212a171a0e9badbc8f5
Autor:
Zong‐Kang Zhang, Jie Li, Daogang Guan, Chao Liang, Zhenjian Zhuo, Jin Liu, Aiping Lu, Ge Zhang, Bao‐Ting Zhang
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 9, Iss 3, Pp 613-626 (2018)
Abstract Background Skeletal muscle atrophy induced by either aging (sarcopenia) or mechanical unloading is associated with serious health consequences. Long non‐coding RNAs (lncRNAs) are implicated as important regulators in numerous physiological
Externí odkaz:
https://doaj.org/article/5c67c3b642b04109b6b1d86bd12655fc