Precision-cut kidney slices (PCKS) to study development of renal fibrosis and efficacy of drug targeting ex vivo

Autor: Fariba Poosti, Bao Tung Pham, Dorenda Oosterhuis, Klaas Poelstra, Harry van Goor, Peter Olinga, Jan-Luuk Hillebrands

Publikováno v: Disease Models & Mechanisms, Vol 8, Iss 10, Pp 1227-1236 (2015)

Renal fibrosis is a serious clinical problem resulting in the greatest need for renal replacement therapy. No adequate preventive or curative therapy is available that could be clinically used to target renal fibrosis specifically. The search for new

Externí odkaz: https://doaj.org/article/2f3fd070fc7b47dabfa1ed111d860044

Murine Precision-cut Intestinal Slices as a Potential Screening Tool for Antifibrotic Drugs

Autor: Bao Tung Pham, Dorenda Oosterhuis, Peter Olinga, S. Suriguga, Raditya Iswandana, Henricus A. M. Mutsaers, Louise A van Wijk, Yvette J. M. Jansen, Theerut Luangmonkong

Publikováno v: Inflammatory Bowel Diseases, 26(5), 678-686. LIPPINCOTT WILLIAMS & WILKINS
Iswandana, R, Pham, B T, Suriguga, S, Luangmonkong, T, van Wijk, L A, Jansen, Y J M, Oosterhuis, D, Maria Mutsaers, H A & Olinga, P 2020, ' Murine Precision-cut Intestinal Slices as a Potential Screening Tool for Antifibrotic Drugs ', Inflammatory Bowel Diseases, vol. 26, no. 5, pp. 678-686 . https://doi.org/10.1093/ibd/izz329
Inflammatory Bowel Diseases

Background Intestinal fibrosis is a hallmark of Crohn’s disease. Here, we investigated the impact of several putative antifibrotic compounds on the expression of fibrosis markers using murine precision-cut intestinal slices. Methods Murine precisio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f07eb3c31b014f633eab024331fa8a
https://research.rug.nl/en/publications/f096b1a0-e9f4-47cd-b1c2-69313179b8e0

Organ- and species-specific biological activity of rosmarinic acid

Autor: Theerut Luangmonkong, Raditya Iswandana, Bao Tung Pham, Peter Olinga, Dorenda Oosterhuis, Henricus A. M. Mutsaers, W. T. van Haaften

Publikováno v: Toxicology in Vitro, 32, 261-268. PERGAMON-ELSEVIER SCIENCE LTD

Rosmarinic acid (RA), a compound found in several plant species, has beneficial properties, including anti-inflammatory and antibacterial effects. We investigated the toxicity, anti-inflammatory, and antifibrotic effects of RA using precision-cut liv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad742356aaf9d23a6ab8e1115ab3053
https://doi.org/10.1016/j.tiv.2016.01.009

Precision-cut rat, mouse, and human intestinal slices as novel models for the early-onset of intestinal fibrosis

Autor: Judith Nieken, Bao Tung Pham, Inge A. M. de Graaf, Wouter T. van Haaften, Dorenda Oosterhuis, Peter Olinga

Publikováno v: Physiological Reports
Physiological Reports, 3(4):e12323. Wiley

Intestinal fibrosis (IF) is a major complication of inflammatory bowel disease. IF research is limited by the lack of relevant in vitro and in vivo models. We evaluated precision-cut intestinal slices (PCIS) prepared from human, rat, and mouse intest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342baab6aae6d645b53ae7002dc7d343
https://pubmed.ncbi.nlm.nih.gov/25907784

Results of the 4th scientific workshop of the ECCO (Group II): markers of intestinal fibrosis in inflammatory bowel disease

Autor: Vito Annese, Iris Dotan, Fernando Magro, Konstantinos H. Katsanos, Peter D.R. Higgins, Florian Rieder, Bao Tung Pham, Jessica R. de Bruyn

Publikováno v: Journal of Crohn's and Colitis, 8(10), 1166-1178. Oxford University Press

The fourth scientific workshop of the European Crohn's and Colitis Organization (ECCO) focused on intestinal fibrosis in inflammatory bowel disease (IBD). The objective was to better understand basic mechanisms and markers of intestinal fibrosis as w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a0a3bebe785652112f18faad878dba
https://research.rug.nl/en/publications/740adc92-467e-4f3b-b6eb-ac552919df6b